Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute

Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute Publisher

Bagheri SSF² ; Gholizadeh M³ ; Sharifi S¹ ; Panahi P¹ ; Esmati E² ; Lashkari M² ; Jalaeefar A⁴ ; Shirkhoda M⁴ ; Shahsiah R¹ ; Ghalehtaki R²

Show Affiliations

1. Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2023

Abstract

Background & Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well defined. Methods: We carried out HER2/neu expression, dMMR/MSI high, and PI3KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran. Results: None of the patients showed HER2 expression, dMMR/MSI high, or PI3K mutations. Conclusion: dMMR/MSI-H and PI3KCA mutation and HER2 expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC. © 2023, Iranian Society of Pathology. All rights reserved.

2. Improved Microsatellite Instability Detection in Colorectal Cancer Patients by a Combination of Fourteen Markers Especially Dnmt3a, Dcd, and Mt1x, Cancer Biomarkers (2021)

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Reza Malekzadeh (1)

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Style	Citing Format
MLA	Bagheri SSF, et al.. "Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute." Iranian Journal of Pathology, vol. 18, no. 1, 2023, pp. 96-103.
APA	Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, Jalaeefar A, Shirkhoda M, Shahsiah R, Ghalehtaki R (2023). Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute. Iranian Journal of Pathology, 18(1), 96-103.
Chicago	Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, Jalaeefar A, Shirkhoda M, Shahsiah R, Ghalehtaki R. "Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute." Iranian Journal of Pathology 18, no. 1 (2023): 96-103.
Harvard	Bagheri SSF et al. (2023) 'Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute', Iranian Journal of Pathology, 18(1), pp. 96-103.
Vancouver	Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, et al.. Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute. Iranian Journal of Pathology. 2023;18(1):96-103.
BibTex	@article{ author = {Bagheri SSF and Gholizadeh M and Sharifi S and Panahi P and Esmati E and Lashkari M and Jalaeefar A and Shirkhoda M and Shahsiah R and Ghalehtaki R}, title = {Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute}, journal = {Iranian Journal of Pathology}, volume = {18}, number = {1}, pages = {96-103}, year = {2023} }
RIS	TY - JOUR AU - Bagheri SSF AU - Gholizadeh M AU - Sharifi S AU - Panahi P AU - Esmati E AU - Lashkari M AU - Jalaeefar A AU - Shirkhoda M AU - Shahsiah R AU - Ghalehtaki R TI - Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute JO - Iranian Journal of Pathology VL - 18 IS - 1 SP - 96 EP - 103 PY - 2023 ER -

Style

Citing Format

MLA

Bagheri SSF, et al.. "Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute." Iranian Journal of Pathology, vol. 18, no. 1, 2023, pp. 96-103.

APA

Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, Jalaeefar A, Shirkhoda M, Shahsiah R, Ghalehtaki R (2023). Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute. Iranian Journal of Pathology, 18(1), 96-103.

Chicago

Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, Jalaeefar A, Shirkhoda M, Shahsiah R, Ghalehtaki R. "Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute." Iranian Journal of Pathology 18, no. 1 (2023): 96-103.

Harvard

Bagheri SSF et al. (2023) 'Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute', Iranian Journal of Pathology, 18(1), pp. 96-103.

Vancouver

Bagheri SSF, Gholizadeh M, Sharifi S, Panahi P, Esmati E, Lashkari M, et al.. Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute. Iranian Journal of Pathology. 2023;18(1):96-103.

BibTex

@article{ author = {Bagheri SSF and Gholizadeh M and Sharifi S and Panahi P and Esmati E and Lashkari M and Jalaeefar A and Shirkhoda M and Shahsiah R and Ghalehtaki R}, title = {Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute}, journal = {Iranian Journal of Pathology}, volume = {18}, number = {1}, pages = {96-103}, year = {2023} }

RIS

TY - JOUR
AU - Bagheri SSF
AU - Gholizadeh M
AU - Sharifi S
AU - Panahi P
AU - Esmati E
AU - Lashkari M
AU - Jalaeefar A
AU - Shirkhoda M
AU - Shahsiah R
AU - Ghalehtaki R
TI - Frequency of Her2 Expression, Mmr Deficiency, and Pi3kca Mutation in Pretreated Surgical Specimens of Patients With Esophageal Squamous Cell Carcinoma in Iran Cancer Institute
JO - Iranian Journal of Pathology
VL - 18
IS - 1
SP - 96
EP - 103
PY - 2023
ER -

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