Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effectiveness of Synbiotics in Preventing Antibiotic-Associated Diarrhea in Children: A Double-Blind Randomized Clinical Trial Publisher



Goli M1 ; Pourmoghaddas Z2, 3 ; Emadoleslami MS2 ; Rahimi H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Archives of Pediatric Infectious Diseases Published:2019


Abstract

Background: Antibiotic-associated diarrhea (AAD) is of great concern in children due to the wide range of antibiotic administration among this population. Studies considering the use of synbiotics for prevention or treatment of AAD are limited. In the current study, the effectiveness of synbiotics in preventing AAD was investigated. Methods: This randomized, double-blinded clinical trial was conducted on 100 patients undergoing antibiotic therapy for over five days. The patients were randomly divided into a case group receiving synbiotic therapy (Protexin; The United Kingdom) and a control group undergoing placebo therapy (consisting of starch sachets). Both groups began their medication within 24 hours after antibiotic initiation and continued it for further seven days after antibiotic therapy cessation. The two groups were compared regarding the incidence of diarrhea, stool consistency based on the Bristol Stool Scale (BSS), and the duration of diarrhea. Results: The members of case and control groups were not statistically different regarding age, gender distribution, length of hospitalization, the frequency of defecation, and stool consistency based on BSS before antibiotic therapy, primary and final diagnosis, the type of antibiotics prescribed, and duration of antibiotic therapy (P > 0.05). The incidence of AAD was significantly less in the case group compared with the control group (P = 0.016), while those with AAD did not show significant difference regarding the duration of diarrhea, stool consistency based on BSS, and the frequency of defecation a day (P = 0.51, 0.26, and 0.18, respectively). Conclusions: The findings of this study showed that early initiation of synbiotics and its long-term administration following antibiotic therapy cessation could considerably prevent AAD; however, in case of AAD occurrence synbiotic therapy cannot positively affect duration, stool consistency, and the frequency of defecation. © 2019, Pediatric Infection Research Center. All rights reserved.
Related Docs
View other Related Docs
1. The Efficacy of a Synbiotic Containing Bacillus Coagulans in Treatment of Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial, Gastroenterology and Hepatology from Bed to Bench (2014)
2. Effectivness of Probiotic on Treatment of Helicobacter Pylori Infection in Children, Journal of Isfahan Medical School (2011)
3. Efficiency of Dimethicone and Symbiotic Approaches in Infantile Colic Management, Iranian Journal of Neonatology (2021)
4. Synbiotic Containing Bacillus Coagulans and Fructo-Oligosaccharides for Functional Abdominal Pain in Children, Gastroenterology and Hepatology from Bed to Bench (2015)
5. The Effect of a Yeast Probiotic on Acute Diarrhea in Children, Probiotics and Antimicrobial Proteins (2016)
6. Efficacy and Safety of Saccharomyces Boulardii for Acute Diarrhea, Pediatrics (2014)
7. The Effects of Probiotic Supplementation on Functional Constipation Following Colonoscopy: A Double-Blinded Randomized Controlled Trial, Current Nutrition and Food Science (2025)
8. Prevalence and Antibiotic Resistance Profile of Shiga Toxin-Producing Escherichia Coli Isolated From Diarrheal Samples, Iranian Journal of Microbiology (2020)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (10)
Maryam Soheilipour (6)
Other Related Docs
9. Comparison of the Effect of Sequential Use of Metronidazole and Probiotics With Probiotics Alone on Functional Bloating; [مقایسه اثر مصرف متوالی مترونیدازول و پروبیوتیک با پروبیوتیک به تنهایی بر نفخ عملکردی], Tehran University Medical Journal (2023)
10. Surveillance of Antibiotic Consumption Point Prevalence Survey 2014: Antimicrobial Prescribing in Pediatrics Wards of 16 Iranian Hospitals, Archives of Iranian Medicine (2016)
11. Evaluation and Comparison of Therapeutic Effects of Probiotics and Colloidal Bismuth Subcitrate on Abdominal Bloating, Caspian Journal of Internal Medicine (2023)
12. The Effect of Residual Antibiotics in Food on Intestinal Microbiota: A Systematic Review, Frontiers in Sustainable Food Systems (2023)
13. Metabolomics Analysis Revealed Metabolic Changes in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Metabolic Responses to a Synbiotic Yogurt Intervention, European Journal of Nutrition (2019)
14. Iranian Association of Gastroenterology and Hepatology Position Statement in Management of Inflammatory Bowel Disease by Using Biological Drugs: Expert View; [بیانیه انجمن گوارش و کبد ایران در مورد مصرف داروهای بیولوژیک در بیماری هایالتهابی روده], Govaresh (2022)
15. Molecular Epidemiology of Clostridium Difficile Infection in Iranian Hospitals, Antimicrobial Resistance and Infection Control (2019)
16. Probiotics Against Viruses; Covid-19 Is a Paper Tiger: A Systematic Review, Endocrine, Metabolic and Immune Disorders - Drug Targets (2021)
17. Widespread Antibiotic Resistance of Diarrheagenic Escherichia Coli and Shigella Species, Journal of Research in Medical Sciences (2014)
18. Vancomycin Infusion Methods on Phlebitis Prevention in Children, Iranian Journal of Nursing and Midwifery Research (2019)
19. Effects of Synbiotic Supplementation on Anthropometric Indices and Body Composition in Overweight or Obese Children and Adolescents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, World Journal of Pediatrics (2023)
20. A Pediatric Case of Antibiotic-Associated Hemorrhagic Colitis Caused by Klebsiella Oxytoca, International Journal of Preventive Medicine (2019)
21. Effects of Probiotics With or Without Honey on Radiation-Induced Diarrhea, International Journal of Radiation Research (2016)
22. Therapeutics Effects of Bovine Colostrum Applications on Gastrointestinal Diseases: A Systematic Review, Systematic Reviews (2024)
23. Association Between Giardia Duodenalis Infection and Irritable Bowel Syndrome, Acta Medica Iranica (2023)
24. Systematic Review With Meta-Analysis: Effects of Probiotic Supplementation on Symptoms in Functional Dyspepsia, Journal of Functional Foods (2020)
25. Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial, Obesity Surgery (2024)
26. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
27. Lactose-Free Compared With Lactose-Containing Formula in Dietary Management of Acute Childhood Diarrhea, Iranian Journal of Pediatrics (2012)
28. Comparison of Lactobacillus Sporogenes Plus Mineral Oil and Mineral Oil Alone in the Treatment of Childhood Functional Constipation, Journal of Research in Medical Sciences (2013)
29. Antimicrobial Potential of Probiotic Strains From Bulgarian Cheese and Shallot Yogurt Against Staphylococcus Saprophyticus, BioMed research international (2024)
30. Effects of Probiotic Yogurt Consumption on Intestinal Permeability in Inflammatory Bowel Disease: A Double-Blind Randomized Clinical Trial, Koomesh (2021)
31. Clostridium Difficile Infection in an Iranian Hospital, BMC Research Notes (2012)
32. Comparing the Efficacy of Polyethylene Glycol (Peg), Magnesium Hydroxide and Lactulosein Treatment of Functional Constipation in Children, Journal of Research in Medical Sciences (2012)
33. The Effect of Biofeedback Therapy on Dyssynergic Constipation in Patients With or Without Irritable Bowel Syndrome, Journal of Research in Medical Sciences (2014)
34. Prevalence and Risk Factors of Clostridium Difficile-Associated Diarrhea in Iranian Hospitalized Patients, Annals of Tropical Medicine and Public Health (2013)
35. The Efficacy of Levofloxacin Versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study, Journal of Isfahan Medical School (2020)
36. The Effect of Zinc Sulfate on Acute Diarrhea in Children Based on the Socioeconomic Status of Parents in Isfahan City, Iran, Journal of Isfahan Medical School (2019)
37. Antibiotic Susceptibility Patterns of Isolates From Children With Urinary Tract Infection in Isfahan, Iran: Impact on Empirical Treatment, Journal of Global Antimicrobial Resistance (2017)
38. Antimicrobial Activity of a Uv-Stable Bacteriocin-Like Inhibitory Substance (Blis) Produced by Enterococcus Faecium Strain Dsh20 Against Vancomycin-Resistant Enterococcus (Vre) Strains, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (2014)
39. The Severity of Symptoms After Preparation for Colonoscopy in Irritable Bowel Syndromes; [شدت علایم در بیماران مبتلا به سندرم روده ی تحریک پذیر پس از آماده سازی برای کولونوسکپی], Journal of Isfahan Medical School (2023)
40. Antibiotic Prescribing Pattern in Neonates of Seventeen Iranian Hospitals, Archives of Pediatric Infectious Diseases (2017)
41. A Systematic Review of the Beneficial Effects of Prebiotics, Probiotics, and Synbiotics on Adhd, Neuropsychopharmacology Reports (2024)
42. Effects of Pro-/Synbiotic Supplementation on Anthropometric and Metabolic Indices in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2019)
43. A Double-Blind Randomized Clinical Trial of Dracocephalum Kotschyi Boiss. in the Patients With Diarrhea-Predominant Irritable Bowel Syndrome, Research in Pharmaceutical Sciences (2023)
44. Prebiotics for the Management of Hyperbilirubinemia in Preterm Neonates, Journal of Maternal-Fetal and Neonatal Medicine (2016)
45. The Relative Frequency of Clostridium Difficile in Fecal Samples of Hospitalized Patients With Diarrhea by Elisa Method, Journal of Isfahan Medical School (2012)
46. The Effect of Probiotic and Synbiotic Consumption on the Most Prev-Alent Chemotherapy-Related Complications: A Systematic Review of Current Literature, Current Medicinal Chemistry (2022)
47. The Effects of Probiotics in Ulcerative Colitis Patients: A Randomized Controlled Double Blind Clinical Trial, Functional Foods in Health and Disease (2023)
48. Effects of Synbiotics on Treatment of Children With Failure to Thrive: A Triple Blind Placebo-Controlled Trial, Journal of Research in Medical Sciences (2014)
49. The Effects of Probiotic/Synbiotic on Serum Level of Zonulin As a Biomarker of Intestinal Permeability: A Systematic Review and Meta-Analysis, Iranian Journal of Public Health (2020)
50. Effects of Probiotic Drop Containing Lactobacillus Rhamnosus, Bifidobacterium Infantis, and Lactobacillus Reuteri on Salivary Streptococcus Mutans and Lactobacillus Levels, Contemporary Clinical Dentistry (2016)