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The Combined Effect of Vitamin C and Omega-3 Polyunsaturated Fatty Acids on Fatigue Following Coronary Artery Bypass Graft Surgery: A Triple-Blind Clinical Trial Publisher Pubmed



Gholami M1 ; Najafizadeh H2 ; Teimouri H3 ; Ardalan A4 ; Pooria A3 ; Tarrahi MJ5
Authors
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Authors Affiliations
  1. 1. School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Department of Cardiac Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. 563 hampshire Rd, Apt 273, Westlake Village, 91361, CA, United States
  5. 5. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Complementary and Integrative Medicine Published:2019


Abstract

Fatigue is a common compliant among patients who undergo coronary artery bypass graft (CABG) surgery. This may affect patients' function in all aspects. A few studies have already assessed the influence of complementary therapies on minimizing fatigue. This study aimed to investigate the combined effect of Vitamin C and omega-3 polyunsaturated fatty acids (n-3 PUFA) on fatigue following CABG surgery. In this randomized, triple-blind placebo-controlled trial, 160 patients who already underwent CABG surgery were randomly assigned into an experimental or a control groups. Each group consisted of 80 patients. The experimental group was given both n-3 PUFA and Vitamin C the day before surgery. They also received the same supplements in the first 5 days of operation. The control group received only placebo. Subjects in both groups responded to Multidimensional Fatigue Inventory (MFI-20) scale in the beginning, and at the end of the intervention as well as on the fifth day of the operation. Chi-square test and independent t-test were used for data analysis. The mean fatigue score in experimental and control groups came up to 62.01 ± 4.06 and 67.92 ± 4.95 (p<0.0001), respectively, which was greater than that of the values we had before intervention. The mean difference of fatigue score was 3.97 ± 3.49 and 9.56 ± 6.41 (p<0.0001) prior and following the intervention, correspondingly. Combination of Vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo CABG surgery. © 2019 2019 Walter de Gruyter GmbH, Berlin/Boston.
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