C-Reactive Protein Levels in Chronic Gingivitis, Chronic Periodontitis and Periodontally Healthy Subjects



Vahid E¹ ; Abdolsafa S² ; Shahram J² ; Manouchehr M³ Show Affiliations
Source: HealthMED Published:2012

Abstract

Background and aim: It has been shown that there is a relationship between periodontal diseases and cardiovascular events. C-reactive protein (CRP) is one of the acute phase reactant which increases in periodontitis and also is known as a potential risk factor in cardiovascular diseases. This study designed to compare the CRP level in chronic gingivitis, chronic periodontitis and periodontally healthy population. Materials and methods: In this cross-sectional study, 50 persons aged 22-53 years were enrolled from those who were visited in periodontix ward of Isfahan Azad University of dentistry, 2008-2009. Twenty five were diagnosed as chronic periodontitis, 20 were chronic gingivitis and five were periodontally healthy. Inclusion criteria were as followings: no systemic disease, non-smokers, not on oral contraceptive pills or other medicine affecting on CRP level, not pregnant, having at least 20 teeth and at least 5 bleeding areas during probing in cases with gingivitis. Periodontal examination included probing depth and attachment loss measurements, gingival recession and Leo and Sillness gingival index. Blood samples were collected from all subjects. CRP was measured using agglutination method (Spinreact kit, Spain) and results were showed as a range of negative to 3 plus. Data were analyzed using Kruskal-Wilis and t-test. Results: There was no significant difference between three groups but mean gingival index, probing depth and attachment loss were significantly higher in CRP positive compared to the negative ones. CRP increased while increasing severity and extent of periodontal disease. Conclusion: CRP should be kept in mind when there is a periodontal disease, although no significant differences were seen. Further quantitative study on CRP levels could be suggested.