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Ultrasound-Guided Chemoradiotherapy of Breast Cancer Using Smart Methotrexate-Loaded Perfluorohexane Nanodroplets Publisher Pubmed



Samani RK1, 2 ; Maghsoudinia F3 ; Mehradnia F4 ; Hejazi SH5 ; Saeb M2 ; Sobhani T2 ; Farahbakhsh Z6 ; Mehrgardi MA7 ; Tavakoli MB2
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Radiology, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Medical Imaging and Radiation Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, United Kingdom
  5. 5. Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  6. 6. Department of Medical Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

Source: Nanomedicine: Nanotechnology, Biology, and Medicine Published:2023


Abstract

Chemoradiotherapy with controlled-release nanocarriers such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded perfluorohexane NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated in vitro and in vivo. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with X-ray irradiation. The in vitro and in vivo results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and organ toxicity. Furthermore, the in vivo results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer. © 2023
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