Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Thermosensitive Folic Acid-Targeted Poly (Ethylene-Co-Vinyl Alcohol) Hemisuccinate Polymeric Nanoparticles for Delivery of Epirubicin to Breast Cancer Cells Publisher



Hassanzadeh F1 ; Maaleki S2 ; Varshosaz J3 ; Khodarahmi GA2 ; Farzan M2 ; Rostami M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Novel Drug Delivery Systems Research Centre and Department of Medicinal Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  2. 2. Department of Medicinal Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Polymer Journal (English Edition) Published:2016


Abstract

A novel thermosensitive folic acid (FA)-targeted succinylated poly (ethylene-co-vinyl alcohol) (EVOH) (EVOHS-FA) nanocarrier was synthesized for the specific delivery of epirubicin (EPI) to MCF-7 breast cancer cell line. Three different ratios of synthesized EVOH-Suc were reacted with FA. The structure of the desired products (EVOHS40-FA, EVOHS60-FA and EVOHS80-FA) was confirmed by 1H NMR and FTIR techniques. Nanoparticles were obtained by nano-precipitation procedure using DMSO/H2O as solvent/anti-solvent. The particle size, zeta potential, entrapment efficacy and in vitro release profile of the final formulations in different temperatures were measured. The optimized nanoparticles had the particle size of 214 ± 8.5 nm, zeta potential of −29.6 mV, PDI of 0.198 ± 0.04, and a high encapsulation efficiency that released the drug efficiently within 450 h at the temperature of 40 °C compared to 37 °C. The morphology of nanoparticles was studied by scanning electron microscopy. The in vitro cytotoxicity was evaluated using the MTT assay on MCF-7 cell lines in response to temperatures of 37 and 40 °C. The MTT assay indicated that the targeted nanoparticles carrying EPI were significantly more cytotoxic than the non-targeted nanoparticles and the free drug at 40 °C. © 2016, Iran Polymer and Petrochemical Institute.
Related Docs
View other Related Docs
1. Poly (Ethylene-Co-Vinyl Alcohol)-Based Polymeric Thermo-Responsive Nanocarriers for Controlled Delivery of Epirubicin to Hepatocellular Carcinoma, Research in Pharmaceutical Sciences (2017)
2. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
3. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
4. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
5. Biodegradable Plga Implants Containing Doxorubicin-Loaded Chitosan Nanoparticles for Treatment of Breast Tumor-Bearing Mice, International Journal of Biological Macromolecules (2019)
6. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
7. Uptake of Etoposide in Ct-26 Cells of Colorectal Cancer Using Folate Targeted Dextran Stearate Polymeric Micelles, BioMed Research International (2014)
8. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (63)
Farshid Hassanzadeh (34)
Other Related Docs
9. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
10. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
11. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
12. Antitumor Activity of Raloxifene-Targeted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide) Co-Polymeric Nanomicelles Loaded With Docetaxel in Breast Cancer-Bearing Mice, Investigational New Drugs (2018)
13. Encapsulation of Drug-Loaded Graphene Oxide-Based Nanocarrier Into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer, Macromolecular Chemistry and Physics (2021)
14. Anti Her-2 Aptamer Functionalized Gold Nanoparticles of Dasatinib for Targeted Chemo-Radiotherapy in Breast Cancer Cells, Biomaterials Advances (2023)
15. Transferrin-Targeted Poly(Butylene Adipate)/Terephthalate Nanoparticles for Targeted Delivery of 5-Fluorouracil in Ht29 Colorectal Cancer Cell Line, Journal of Bioactive and Compatible Polymers (2017)
16. Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors, Vaccines (2022)
17. Ultrasound-Guided Chemoradiotherapy of Breast Cancer Using Smart Methotrexate-Loaded Perfluorohexane Nanodroplets, Nanomedicine: Nanotechnology, Biology, and Medicine (2023)
18. Gene Delivery by Pei-Nanocomplex Into Breast and Colorectal Tumor Cell Lines, the Impacts of N/P Ratio, Size and Type of the Cell; [Pei-Nanocomplex Tarafindan Meme Ve Kolorektal Tumor Hucre Hatlarinda Gen Dagitimi, N / P Oraninin, Hucrenin Boyutu Ve Turunun Etkileri], Fabad Journal of Pharmaceutical Sciences (2020)
19. Efavirenz Oral Delivery Via Lipid Nanocapsules: Formulation, Optimisation, and Ex-Vivo Gut Permeation Study, IET Nanobiotechnology (2018)
20. Mesoporous Silica@Chitosan@Gold Nanoparticles As “On/Off” Optical Biosensor and Ph-Sensitive Theranostic Platform Against Cancer, International Journal of Biological Macromolecules (2022)
21. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
22. Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications, Advanced Healthcare Materials (2022)
23. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
24. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
25. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
26. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
27. Encapsulation of Bioactives Within Electrosprayed Κ-Carrageenan Nanoparticles, Carbohydrate Polymers (2022)
28. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
29. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
30. Protein-Polysaccharide Interactions for the Fabrication of Bioactive-Loaded Nanocarriers: Chemical Conjugates and Physical Complexes, Pharmacological Research (2022)
31. Pharmacokinetics, Organ Toxicity and Antitumor Activity of Docetaxel Loaded in Folate Targeted Cholesterol Based Micelles, Current Drug Delivery (2016)
32. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
33. Anticancer Nano-Delivery Systems Based on Bovine Serum Albumin Nanoparticles: A Critical Review, International Journal of Biological Macromolecules (2021)
34. Docetaxel-Loaded Nanostructured Lipid Carriers Functionalized With Trastuzumab (Herceptin) for Her2-Positive Breast Cancer Cells, Journal of Liposome Research (2018)
35. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
36. Biosynthesis of Lead Oxide and Cerium Oxide Nanoparticles and Their Cytotoxic Activities Against Colon Cancer Cell Line, Inorganic Chemistry Communications (2021)
37. Improving the Solubility and in Vitro Cytotoxicity (Anticancer Activity) of Ferulic Acid by Loading It Into Cyclodextrin Nanosponges, International Journal of Nanomedicine (2019)
38. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
39. Pharmacokinetics and in Vitro/In Vivo Antitumor Efficacy of Aptamer-Targeted Ecoflex® Nanoparticles for Docetaxel Delivery in Ovarian Cancer, International Journal of Nanomedicine (2018)
40. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling, Journal of Nanomaterials (2013)
41. Synthesis of Biotin-Targeted Chitosan/Poly (Methyl Vinyl Ether- Alt -Maleic Acid) Copolymeric Micelles for Delivery of Doxorubicin, IET Nanobiotechnology (2017)
42. How Do Various Encapsulation Techniques Improve the Oral Delivery of Food Protein Hydrolysates?, Food Frontiers (2025)
43. Cytotoxic Effects of Targeted Galactosylated Pluronic F127/Pluronicl122 Nano-Sized Micelles Loaded With Doxorubicin in Human Hepatocellular Carcinoma Cell Line, Journal of Isfahan Medical School (2013)
44. Evaluation of Thermosensitive Chitosan Hydrogel Containing Gefitinib Loaded Cellulose Acetate Butyrate Nanoparticles in a Subcutaneous Breast Cancer Model, International Journal of Pharmaceutics (2022)
45. Targeted Delivery of Docetaxel by Use of Transferrin/Poly(Allylamine Hydrochloride)-Functionalized Graphene Oxide Nanocarrier, ACS Applied Materials and Interfaces (2016)
46. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
47. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
48. Poly (Butylene Adipate-Co-Terephthalate) Electrospun Nanofibers Loaded With 5-Fluorouracil and Curcumin in Treatment of Colorectal Cancer Cells, Polymer Testing (2018)
49. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
50. Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances, Nanomaterials (2022)