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Genome-Wide Association Analysis Identifies Novel Blood Pressure Loci and Offers Biological Insights Into Cardiovascular Risk Publisher Pubmed



Warren HR1, 2 ; Evangelou E3, 4 ; Cabrera CP1, 2 ; Gao H3, 5 ; Ren M1, 2, 147 ; Mifsud B1 ; Ntalla I1 ; Surendran P6 ; Liu C7, 8 ; Cook JP9 ; Kraja AT10 ; Drenos F11, 12 ; Loh M3, 13 ; Verweij N14, 16 Show All Authors
Authors
  1. Warren HR1, 2
  2. Evangelou E3, 4
  3. Cabrera CP1, 2
  4. Gao H3, 5
  5. Ren M1, 2, 147
  6. Mifsud B1
  7. Ntalla I1
  8. Surendran P6
  9. Liu C7, 8
  10. Cook JP9
  11. Kraja AT10
  12. Drenos F11, 12
  13. Loh M3, 13
  14. Verweij N14, 16
  15. Marten J17
  16. Karaman I3
  17. Segura Lepe MP3, 18
  18. Oreilly PF19
  19. Knight J20
  20. Snieder H21
  21. Kato N22
  22. He J23
  23. Shyong Tai E24, 25
  24. Abdullah Said M14
  25. Porteous D26
  26. Alver M27, 174
  27. Poulter N28
  28. Farrall M29, 86
  29. Gansevoort RT30
  30. Padmanabhan S31, 108, 140
  31. Magi R27, 174
  32. Stanton A32
  33. Connell J33
  34. Bakker SJL34
  35. Metspalu A27, 174
  36. Shields DC35
  37. Thom S36, 160
  38. Brown M1, 2
  39. Sever P36
  40. Esko T15, 27, 62, 174
  41. Hayward C17, 108
  42. Van Der Harst P14
  43. Saleheen D37, 38
  44. Chowdhury R6
  45. Chambers JC3, 39, 40, 41, 47
  46. Chasman DI42, 43
  47. Chakravarti A44
  48. Newtoncheh C15, 16
  49. Lindgren CM15, 45, 46
  50. Levy D7, 8
  51. Kooner JS36, 40, 47, 48
  52. Keavney B49, 50
  53. Tomaszewski M49, 50
  54. Samani NJ51, 52
  55. Howson JMM6
  56. Tobin MD53
  57. Munroe PB1, 2
  58. Ehret GB44, 54
  59. Wain LV53
  60. Barnes MR1, 2
  61. Tzoulaki I3, 5
  62. Caulfield MJ1, 2
  63. Elliott P3, 5
  64. Wain V53
  65. Vaez A21, 55
  66. Jansen R56
  67. Joehanes R8, 57
  68. Van Der Most PJ21
  69. Mesut Erzurumluoglu A53
  70. Rose LM42
  71. Verwoert GC58
  72. Hottenga JJ59
  73. Strawbridge RJ60, 61
  74. Arking DE44
  75. Hwang SJ64, 65
  76. Guo X66
  77. Kutalik Z67, 68
  78. Trompet S69, 70
  79. Shrine N53
  80. Teumer A71, 72
  81. Ried JS73
  82. Bis JC74
  83. Smith AV75, 76
  84. Amin N77
  85. Nolte IM21
  86. Lyytikainen LP78, 79
  87. Mahajan A45
  88. Wareham NJ80
  89. Hofer E81, 82
  90. Joshi PK83
  91. Kristiansson K84
  92. Traglia M85
  93. Havulinna AS84
  94. Goel A45, 86
  95. Nalls MA87, 88
  96. Sober S89
  97. Vuckovic D90, 91
  98. Luan J80
  99. Fabiola Del Greco M92, 93
  100. Ayers KL94
  101. Marrugat J95
  102. Ruggiero D96
  103. Lopez LM97, 98
  104. Niiranen T84
  105. Enroth S99
  106. Jackson AU100
  107. Nelson CP51, 52
  108. Huffman JE17
  109. Zhang W3, 47
  110. Gandin I91
  111. Harris SE26, 97
  112. Zemonik T101
  113. Lu Y102
  114. Shah N103, 104
  115. De Borst MH34
  116. Mangino M105, 106
  117. Prins BP107
  118. Campbell A26, 108
  119. Ligao R109
  120. Chauhan G110, 111
  121. Oldmeadow C112
  122. Abecasis G113
  123. Abedi M114
  124. Barbieri CM85
  125. Batini C53
  126. Blake T53
  127. Boehnke M100
  128. Bottinger EP102
  129. Braund PS51, 52
  130. Brumat M91
  131. Campbell H83
  132. Cocca M91
  133. Collins F115
  134. Cordell HJ116
  135. Damman JJ117
  136. Davies G97, 118
  137. De Geus EJ59
  138. De Mutsert R109
  139. Deelen J119
  140. Demirkale Y120
  141. Doney ASF103
  142. Dorr M72, 121
  143. Ferreira T45
  144. Franberg M60, 61, 122
  145. Giedraitis V123
  146. Gieger C124
  147. Giulianini F42
  148. Gow AJ97, 125
  149. Hamsten A60, 61
  150. Harris TB126
  151. Hofman A58, 127
  152. Holliday EG112
  153. Jarvelin MR5, 128, 129
  154. Johansson A99
  155. Johnson AD8, 130
  156. Jousilahti P84
  157. Jula A84
  158. Kahonen M131, 132
  159. Kathiresan S15, 16
  160. Khaw KT38
  161. Kolcic I133
  162. Koskinen S84
  163. Langenberg C80
  164. Larson M8
  165. Launer LJ126
  166. Lehne B3
  167. Liewald DCM97, 118
  168. Lin L54
  169. Lind L134
  170. Mach F54
  171. Mamasoula C135
  172. Menni C105
  173. Milaneschi Y136
  174. Morgan A91
  175. Morris AD137
  176. Morrison AC138
  177. Munson PJ120
  178. Nandakumar P44
  179. Nguyen QT120
  180. Nutile T96
  181. Oldehinkel AJ139
  182. Oostra BA77
  183. Org E27, 174
  184. Palotie A141
  185. Pare G142
  186. Pattie A118
  187. Penninx BWJH136
  188. Pramstaller PP92, 93, 143, 144
  189. Raitakari OT145, 146
  190. Rice K148
  191. Ridker PM42, 43
  192. Riese H139
  193. Ripatti S141
  194. Robino A149
  195. Rotter JI66, 150
  196. Rudan I83
  197. Saba Y151
  198. Saint Pierre A92, 93, 152
  199. Sala CF85
  200. Sarin AP141
  201. Schmidt R81
  202. Scott R112, 153, 154
  203. Seelen MA34
  204. Siscovick D155
  205. Sorice R96, 156
  206. Stott DJ31
  207. Sundstrom J134
  208. Swertz M157
  209. Taylor KD158, 159
  210. Tzourio C110, 111, 161
  211. Uitterlinden AG58, 162
  212. Volker U72, 163
  213. Vollenweider P164
  214. Wild S83
  215. Willemsen G59
  216. Wright AF17
  217. Yao J66
  218. Theriault S142
  219. Conen D165
  220. John A112, 153, 154
  221. Debette S110, 111, 166
  222. Mookkanamori DO109, 167
  223. Zeggini E107
  224. Spector TD105
  225. Palmer CNA103
  226. Vergnaud AC3
  227. Loos RJF81, 102, 168
  228. Polasek O133
  229. Starr JM97, 169
  230. Girotto G90, 91
  231. Vitart V17
  232. Tuomilehto J170, 171
  233. Gyllensten U99
  234. Knekt P84
  235. Deary IJ97, 118
  236. Ciullo M96, 156
  237. Elosua R95
  238. Hicks AA92, 93
  239. Scott RA80
  240. Gasparini P90, 91
  241. Laan M89, 172
  242. Liu YM173
  243. Watkins H45, 86
  244. Hartman CA139
  245. Salomaa V84
  246. Toniolo D85
  247. Perola M27, 83, 141, 174
  248. Wilson JF17, 83
  249. Schmidt H151, 175
  250. Zhao JH80
  251. Lehtimaki T78, 79
  252. Van Duijn CM77
  253. Gudnason V75, 76
  254. Psaty BM74, 176, 177
  255. Peters A73
  256. Rettig R178
  257. James A179, 180
  258. Wouter Jukema J69
  259. Strachan DP181
  260. Palmas W182
  261. Ingelsson E183, 184
  262. Boomsma DI59
  263. Franco OH58
  264. Bochud M67
  265. Morris AP9, 45
Show Affiliations
Authors Affiliations
  1. 1. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
  2. 2. National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, United Kingdom
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  4. 4. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
  5. 5. MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
  6. 6. Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  7. 7. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States
  8. 8. National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA, United States
  9. 9. Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom
  10. 10. Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, United States
  11. 11. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
  12. 12. Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom
  13. 13. Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Singapore
  14. 14. University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands
  15. 15. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States
  16. 16. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States
  17. 17. MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
  18. 18. Bayer Pharma, Berlin, Germany
  19. 19. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
  20. 20. Data Science Institute, Lancester University, Lancaster, United Kingdom
  21. 21. University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, Netherlands
  22. 22. Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
  23. 23. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States
  24. 24. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
  25. 25. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  26. 26. Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
  27. 27. Estonian Genome Center, University of Tartu, Tartu, Estonia
  28. 28. Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom
  29. 29. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
  30. 30. University of Groningen, University Medical Center Groningen, Department of Nephrology, Groningen, Netherlands
  31. 31. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
  32. 32. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
  33. 33. Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
  34. 34. University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, Netherlands
  35. 35. School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland
  36. 36. National Heart and Lung Institute, Imperial College London, London, United Kingdom
  37. 37. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  38. 38. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  39. 39. Ealing Hospital National Health Service (NHS) Trust, Southall, United Kingdom
  40. 40. Imperial College Healthcare NHS Trust, London, United Kingdom
  41. 41. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
  42. 42. Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, United States
  43. 43. Harvard Medical School, Boston, MA, United States
  44. 44. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  45. 45. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
  46. 46. Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom
  47. 47. Department of Cardiology, Ealing Hospital NHS Trust, Southall, United Kingdom
  48. 48. National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, United Kingdom
  49. 49. Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
  50. 50. Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
  51. 51. Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, United Kingdom
  52. 52. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
  53. 53. Department of Health Sciences, University of Leicester, Leicester, United Kingdom
  54. 54. Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
  55. 55. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  56. 56. Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, Netherlands
  57. 57. Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, United States
  58. 58. Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
  59. 59. Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ institute, VU University Medical Center, Amsterdam, Netherlands
  60. 60. Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  61. 61. Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden
  62. 62. Division of Endocrinology, Children’s Hospital, Boston, MA, United States
  63. 63. Broad Institute of Harvard and MIT, Cambridge, MA, United States
  64. 64. Population Science Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, United States
  65. 65. Framingham Heart Study, Framingham, MA, United States
  66. 66. Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, United States
  67. 67. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
  68. 68. Swiss Institute of Bioinformatics, Lausanne, Switzerland
  69. 69. Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
  70. 70. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
  71. 71. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  72. 72. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
  73. 73. Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany
  74. 74. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States
  75. 75. Icelandic Heart Association, Kopavogur, Iceland
  76. 76. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  77. 77. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
  78. 78. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
  79. 79. Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland
  80. 80. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
  81. 81. Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria
  82. 82. Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Graz, Austria
  83. 83. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
  84. 84. Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland
  85. 85. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
  86. 86. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
  87. 87. Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, United States
  88. 88. Kelly Services, Rockville, MD, United States
  89. 89. Human Molecular Genetics Research Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
  90. 90. Experimental Genetics Division, Sidra Medical and Research Center, Doha, Qatar
  91. 91. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
  92. 92. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy
  93. 93. Institute of the University of Lubeck, Germany
  94. 94. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  95. 95. Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain
  96. 96. Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy
  97. 97. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
  98. 98. University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland
  99. 99. Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Uppsala, Sweden
  100. 100. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States
  101. 101. Department of Biology, Faculty of Medicine, University of Split, Split, Croatia
  102. 102. Charles Bronfman Institute for Personalized Medicine, Icachn School of Medicine at Mount Sinai, New York, NY, United States
  103. 103. Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
  104. 104. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan
  105. 105. Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom
  106. 106. National Institute for Health Research Biomedical Research Centre, London, United Kingdom
  107. 107. Department of Human Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
  108. 108. Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom
  109. 109. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
  110. 110. INSERM U1219, Bordeaux Population Health Center, Bordeaux, France
  111. 111. Bordeaux University, Bordeaux, France
  112. 112. Hunter Medical Research Institute, New Lambton, NSW, Australia
  113. 113. Center for Statistical Genetics, Department of Biostatistics, SPH II, Ann Arbor, MI, United States
  114. 114. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  115. 115. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, United States
  116. 116. Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
  117. 117. Department of Pathology, Amsterdam Medical Center, Amsterdam, Netherlands
  118. 118. Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
  119. 119. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands
  120. 120. Center for Information Technology, US National Institutes of Health, Bethesda, MD, United States
  121. 121. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
  122. 122. Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden
  123. 123. Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden
  124. 124. Helmholtz Zentrum Munchen, Deutsches Forschungszentrum fur Gesundheit und Umwelt, Neuherberg, Germany
  125. 125. Department of Psychology, School of Life Sciences, Heriot-Watt University, Edinburgh, United Kingdom
  126. 126. Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, United States
  127. 127. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  128. 128. Center For Life-Course Health Research, University of Oulu, Oulu, Finland
  129. 129. Unit of Primary Care, Oulu University Hospital, Oulu, Finland
  130. 130. National Heart, Lung, and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD, United States
  131. 131. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
  132. 132. Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland
  133. 133. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia
  134. 134. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
  135. 135. Institute of Health and Society, Newcastle University, Newcastle-upon-Tyne, United Kingdom
  136. 136. Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
  137. 137. School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, United Kingdom
  138. 138. Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, United States
  139. 139. University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE), Groningen, Netherlands
  140. 140. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
  141. 141. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
  142. 142. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
  143. 143. Department of Neurology, General Central Hospital, Bolzano, Italy
  144. 144. Department of Neurology, University of Lubeck, Lubeck, Germany
  145. 145. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
  146. 146. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
  147. 147. Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
  148. 148. Department of Biostatistics, University of Washington, Seattle, WA, United States
  149. 149. Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
  150. 150. Institute for Translational Genomics and Population Sciences, Department of Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, United States
  151. 151. Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria
  152. 152. INSERM U1078, Etablissement Francais du Sang, Brest, France
  153. 153. Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
  154. 154. School of Biomedical Sciences and Pharmacy, John Hunter Hospital, New Lambton, NSW, Australia
  155. 155. New York Academy of Medicine, New York, NY, United States
  156. 156. IRCCS Neuromed, Pozzilli, Italy
  157. 157. University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands
  158. 158. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States
  159. 159. Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States
  160. 160. International Centre for Circulatory Health, Imperial College London, London, United Kingdom
  161. 161. Department of Public Health, Bordeaux University Hospital, Bordeaux, France
  162. 162. Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands
  163. 163. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
  164. 164. Department of Internal Medicine, Lausanne University Hospital, CHUV, Lausanne, Switzerland
  165. 165. Population Health Research Institute, McMaster University, Hamilton, ON, Canada
  166. 166. Department of Neurology, Bordeaux University Hospital, Bordeaux, France
  167. 167. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands
  168. 168. Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  169. 169. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
  170. 170. Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
  171. 171. Centre for Vascular Prevention, Danube University Krems, Krems, Austria
  172. 172. Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  173. 173. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, United States
  174. 174. Estonian Genome Center, University of Tartu, Tartu, Estonia
  175. 175. Department of Neurology, Medical University Graz, Graz, Austria
  176. 176. Department of Epidemiology University of Washington, Seattle, WA, United States
  177. 177. Group Health Research Institute, Group Health, Seattle, WA, United States
  178. 178. Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany
  179. 179. Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
  180. 180. School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
  181. 181. Population Health Research Institute, St George’s, University of London, London, United Kingdom
  182. 182. Department of Medicine, Columbia University Medical Center, New York, NY, United States
  183. 183. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
  184. 184. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
  185. 185. Boston University School of Public Health, Boston, Massachusetts, USA
  186. 186. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
  187. 187. Centre for Non-Communicable Diseases, Karachi, Pakistan
  188. 188. Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
  189. 189. Biocenter Oulu, University of Oulu, Oulu, Finland
  190. 190. South Ostrobothnia Central Hospital, Seinajoki, Finland
  191. 191. Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain
  192. 192. Department of Health Services, University of Washington, Seattle, Washington, USA

Source: Nature Genetics Published:2017


Abstract

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
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