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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney Publisher Pubmed



Wain LV1 ; Vaez A3, 8 ; Jansen R9 ; Joehanes R10, 11 ; Van Der Most PJ3 ; Erzurumluoglu AM1 ; Oreilly PF12 ; Cabrera CP14, 15 ; Warren HR14, 15 ; Rose LM16 ; Verwoert GC17 ; Hottenga JJ20 ; Strawbridge RJ21, 22 ; Esko T23, 26, 27 Show All Authors
Authors
  1. Wain LV1
  2. Vaez A3, 8
  3. Jansen R9
  4. Joehanes R10, 11
  5. Van Der Most PJ3
  6. Erzurumluoglu AM1
  7. Oreilly PF12
  8. Cabrera CP14, 15
  9. Warren HR14, 15
  10. Rose LM16
  11. Verwoert GC17
  12. Hottenga JJ20
  13. Strawbridge RJ21, 22
  14. Esko T23, 26, 27
  15. Arking DE28
  16. Hwang SJ29, 33
  17. Guo X34
  18. Kutalik Z36, 37
  19. Trompet S38, 39
  20. Shrine N1
  21. Teumer A43, 46
  22. Ried JS47
  23. Bis JC48
  24. Smith AV52, 53
  25. Amin N18
  26. Nolte IM3
  27. Lyytikainen LP54, 55
  28. Mahajan A56
  29. Wareham NJ58
  30. Hofer E59, 60
  31. Joshi PK62
  32. Kristiansson K69
  33. Traglia M71
  34. Havulinna AS69
  35. Goel A56, 57
  36. Nalls MA30, 72
  37. Sober S24
  38. Vuckovic D73, 74
  39. Luan J58
  40. Del Greco FM75
  41. Ayers KL76
  42. Marrugat J79
  43. Ruggiero D80
  44. Lopez LM63, 81, 82
  45. Niiranen T69
  46. Enroth S84
  47. Jackson AU85
  48. Nelson CP2, 86
  49. Huffman JE87
  50. Zhang W90, 95
  51. Marten J87
  52. Gandin I74
  53. Harris SE63, 88, 89
  54. Zemunik T96
  55. Lu Y77
  56. Evangelou E90, 97
  57. Shah N98, 99
  58. De Borst MH4
  59. Mangino M13, 100
  60. Prins BP101
  61. Campbell A64, 65
  62. Ligao R40
  63. Chauhan G102, 103
  64. Oldmeadow C104
  65. Abecasis G105
  66. Abedi M106
  67. Barbieri CM71
  68. Barnes MR14, 15
  69. Batini C1
  70. Beilby J107, 108, 109
  71. Blake T1
  72. Boehnke M85
  73. Bottinger EP77
  74. Braund PS2, 86
  75. Brown M14, 15
  76. Brumat M74
  77. Campbell H62
  78. Chambers JC90, 95, 112
  79. Cocca M74
  80. Collins F31
  81. Connell J113
  82. Cordell HJ114
  83. Damman JJ116
  84. Davies G63, 66
  85. De Geus EJ20
  86. De Mutsert R40
  87. Deelen J41
  88. Demirkale Y32
  89. Doney ASF98
  90. Dorr M44, 46
  91. Farrall M56, 57
  92. Ferreira T56
  93. Franberg M21, 22, 117
  94. Gao H90
  95. Giedraitis V118
  96. Gieger C119
  97. Giulianini F16
  98. Gow AJ63, 120
  99. Hamsten A21, 22
  100. Harris TB121
  101. Hofman A17, 122
  102. Holliday EG104
  103. Hui J107, 108, 109, 110
  104. Jarvelin MR91, 123, 124, 125
  105. Johansson A84
  106. Johnson AD11, 126
  107. Jousilahti P69
  108. Jula A69
  109. Kahonen M127, 128
  110. Kathiresan S129, 130, 132
  111. Khaw KT133
  112. Kolcic I134
  113. Koskinen S69
  114. Langenberg C58
  115. Larson M11
  116. Launer LJ121
  117. Lehne B90
  118. Liewald DCM63, 66
  119. Lin L135
  120. Lind L136
  121. Mach F135
  122. Mamasoula C115
  123. Menni C13
  124. Mifsud B14
  125. Milaneschi Y138
  126. Morgan A74
  127. Morris AD139
  128. Morrison AC140
  129. Munson PJ32
  130. Nandakumar P28
  131. Nguyen QT32
  132. Nutile T80
  133. Oldehinkel AJ5
  134. Oostra BA18
  135. Org E23
  136. Padmanabhan S65, 141
  137. Palotie A143
  138. Pare G144
  139. Pattie A66
  140. Penninx BWJH138
  141. Poulter N92
  142. Pramstaller PP75, 145, 146
  143. Raitakari OT147, 148
  144. Ren M14, 149
  145. Rice K49
  146. Ridker PM16, 150
  147. Riese H5
  148. Ripatti S143
  149. Robino A151
  150. Rotter JI35
  151. Rudan I62
  152. Saba Y152
  153. Saint Pierre A75, 153
  154. Sala CF71
  155. Sarin AP143
  156. Schmidt R59, 61, 152
  157. Scott R104, 154, 155
  158. Seelen MA4
  159. Shields DC83
  160. Siscovick D156
  161. Sorice R80, 157
  162. Stanton A158
  163. Stott DJ142
  164. Sundstrom J136
  165. Swertz M6
  166. Taylor KD159, 160
  167. Thom S93
  168. Tzoulaki I90
  169. Tzourio C102, 103, 161
  170. Uitterlinden AG17, 19
  171. Volker U45, 46
  172. Vollenweider P163
  173. Wild S62
  174. Willemsen G20
  175. Wright AF87
  176. Yao J34
  177. Theriault S144
  178. Conen D164
  179. Attia J104, 154, 155
  180. Sever P94
  181. Debette S102, 103, 162
  182. Mookkanamori DO40, 42
  183. Zeggini E101
  184. Spector TD13
  185. Van Der Harst P7
  186. Palmer CNA98
  187. Vergnaud AC90
  188. Loos RJF58, 77, 78
  189. Polasek O134
  190. Starr JM63, 67
  191. Girotto G73, 74
  192. Hayward C65, 68
  193. Kooner JS95, 112, 165
  194. Lindgren CM27, 56
  195. Vitart V87
  196. Samani NJ2, 86
  197. Tuomilehto J70, 166, 167, 168
  198. Gyllensten U84
  199. Knekt P69
  200. Deary IJ63, 66
  201. Ciullo M80, 157
  202. Elosua R79
  203. Keavney BD169
  204. Hicks AA75
  205. Scott RA58
  206. Gasparini P73, 74
  207. Laan M24
  208. Liu Y170
  209. Watkins H56, 57
  210. Hartman CA5
  211. Salomaa V69
  212. Toniolo D71
  213. Perola M25, 69, 143
  214. Wilson JF62, 87
  215. Zhao JH58
  216. Lehtimaki T54, 55
  217. Van Duijn CM18
  218. Gudnason V52, 53
  219. Psaty BM48, 50, 51, 171
  220. Peters A47
  221. Rettig R172
  222. James A111, 173
  223. Jukema JW38
  224. Strachan DP174
  225. Palmas W175
  226. Metspalu A23
  227. Ingelsson E137, 176
  228. Boomsma DI20
  229. Franco OH17
  230. Bochud M36
  231. Newtoncheh C27, 129, 131, 132
  232. Munroe PB14, 15
  233. Elliott P91
  234. Chasman DI16, 150
  235. Chakravarti A28
  236. Knight J177
  237. Morris AP56, 178
  238. Levy D29, 33
  239. Tobin MD1
  240. Snieder H3
  241. Caulfield MJ14, 15
  242. Ehret GB28, 135
Show Affiliations
Authors Affiliations
  1. 1. Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom
  2. 2. Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, United Kingdom
  3. 3. Department of Epidemiology, United Kingdom
  4. 4. Division of Nephrology, Department of Internal Medicine, United Kingdom
  5. 5. Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE), United Kingdom
  6. 6. Department of Genetics, France
  7. 7. Department of Cardiology, University of Groningen, University Medical Center Groningen, Netherlands
  8. 8. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran
  9. 9. Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Netherlands
  10. 10. Hebrew SeniorLife, Harvard Medical School, Boston, MA, United States
  11. 11. National Heart, Lung and Blood Institute's Framingham Heart Study, MA, United States
  12. 12. Institute of Psychiatry, Psychology and Neuroscience, United States
  13. 13. Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom
  14. 14. Clinical Pharmacology, William Harvey Research Institute, United Kingdom
  15. 15. NIHR Barts Cardiovascular Biomedical Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom
  16. 16. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States
  17. 17. Department of Epidemiolagy, United States
  18. 18. Genetic Epidemiology Unit, Department of Epidemiology, United States
  19. 19. Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands
  20. 20. Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, Netherlands
  21. 21. Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  22. 22. Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden
  23. 23. Estonian Genome Center, Estonia
  24. 24. Institute of Biomedicine and Translational Medicine, Estonia
  25. 25. Estonian Genome Center, University of Tartu, Estonia
  26. 26. Divisions of Endocrinology, Children's Hospital, Boston, MA, United States
  27. 27. Broad Institute of Harvard and MIT, Cambridge, MA, United States
  28. 28. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
  29. 29. Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute, United States
  30. 30. Laboratory of Neurogenetics, National Institute on Aging, United States
  31. 31. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, United States
  32. 32. Center for Information Technology, National Institutes of Health, Bethesda, MD, United States
  33. 33. Framingham Heart Study, Framingham, MA, United States
  34. 34. Institute for Translational Genomics and Population Sciences, Department of Pediatrics, United States
  35. 35. Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, United States
  36. 36. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
  37. 37. Swiss Institute of Bioinformatics, Lausanne, Switzerland
  38. 38. Department of Cardiology, United States
  39. 39. Department of Gerontology and Geriatrics, United States
  40. 40. Department of Clinical Epidemiology, France
  41. 41. Department of Molecular Epidemiology, United States
  42. 42. Department of Public Health and Primary Care, Leiden University Medical Center, Netherlands
  43. 43. Institute for Community Medicine, United States
  44. 44. Department of Internal Medicine B, United States
  45. 45. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany
  46. 46. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany
  47. 47. Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany
  48. 48. Cardiovascular Health Research Unit, Department of Medicine, United States
  49. 49. Department of Biostatistics, United States
  50. 50. Department of Epidemiologi, United States
  51. 51. Department of Health Services, University of Washington, Seattle, United States
  52. 52. Icelandic Heart Association, Kopavogur, Iceland
  53. 53. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  54. 54. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
  55. 55. Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland
  56. 56. Wellcome Trust Centre for Human Genetics, United States
  57. 57. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom
  58. 58. MRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Institute of Metabolic Science, United Kingdom
  59. 59. Clinical Division of Neurogeriatrics, Department of Neurology, United States
  60. 60. Institute of Medical Informatics, Statistics and Documentation, United States
  61. 61. Department of Neurology, Medical University Graz, Austria
  62. 62. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, United States
  63. 63. Centre for Cognitive Ageing and Cognitive Epidemiology, United States
  64. 64. Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, United States
  65. 65. Generation Scotland, Centre for Genomic and Experimental Medicine, United States
  66. 66. Department of Psychology, United States
  67. 67. Alzheimer Scotland Dementia Research Centre, United States
  68. 68. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom
  69. 69. Department of Health, United States
  70. 70. Chronic Disease Prevention Unit, National Institute for Health and Welfare (THL), Helsinki, Finland
  71. 71. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
  72. 72. Data Tecnica International, Glen Echo, MD, United States
  73. 73. Medical Genetics, IRCCS-Burlo Garofolo Children Hospital, Trieste, Italy
  74. 74. Department of Medical, Surgical and Health Sciences, University of Trieste, Italy
  75. 75. Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy
  76. 76. Department of Genetics and Genomic Sciences, United States
  77. 77. Charles Bronfman Institute for Personalized Medicine, United States
  78. 78. Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, United States
  79. 79. Cardiovascular Epidemiology and Genetics, IMIM, CIBERCV, Barcelona, Spain
  80. 80. Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy
  81. 81. Department of Psychiatry, Royal College of Surg. in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
  82. 82. UCD Conway Institute, Centre for Proteome Research, Ireland
  83. 83. School of Medicine, Conway Institute, University College Dublin, Belfield, Ireland
  84. 84. Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden
  85. 85. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, United States
  86. 86. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
  87. 87. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, United States
  88. 88. Medical Genetics Section, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, United States
  89. 89. University of Edinburgh, Western General Hospital, United Kingdom
  90. 90. Department of Epidemiology and Biostatistics, School of Public Health, United States
  91. 91. MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, United States
  92. 92. School of Public Health, United States
  93. 93. International Centre for Circulatory Health, United States
  94. 94. National Heart and Lung Institute, Imperial College London, United Kingdom
  95. 95. Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom
  96. 96. Department of Medical Biology, Faculty of Medicine, University of Split, Croatia
  97. 97. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece
  98. 98. Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, United Kingdom
  99. 99. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan
  100. 100. National Institute for Health Research Biomedical Research Centre, London, United Kingdom
  101. 101. Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom
  102. 102. INSERM U 1219, Bordeaux Population Health Center, France
  103. 103. Bordeaux University, France
  104. 104. Hunter Medical Research Institute, New Lambton, NSW, Australia
  105. 105. Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI, United States
  106. 106. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran
  107. 107. Busselton Population Medical Research Institute, WA, Australia
  108. 108. PathWest Laboratory Medicine of Western Australia, Nedlands, Australia
  109. 109. School of Pathology and Laboratory Medicine, Australia
  110. 110. School of Population and Global Health, Australia
  111. 111. School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia
  112. 112. Imperial College Healthcare NHS Trust, London, United Kingdom
  113. 113. University of Dundee, Ninewells Hospital and Medical School, United Kingdom
  114. 114. Institute of Genetic Medicine, United Kingdom
  115. 115. Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
  116. 116. Department of Pathology, Amsterdam Medical Center, Netherlands
  117. 117. Department of Numerical Analysis and Computer Science, Stockholm University, Sweden
  118. 118. Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden
  119. 119. Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany
  120. 120. Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom
  121. 121. Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, United Kingdom
  122. 122. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  123. 123. Center for Life-Course Health Research, United States
  124. 124. Biocenter Oulu, University of Oulu, Finland
  125. 125. Unit of Primary Care, Oulu University Hospital, Finland
  126. 126. National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD, United States
  127. 127. Department of Clinical Physiology, Tampere University Hospital, Finland
  128. 128. Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland
  129. 129. Cardiovascular Research Center, United States
  130. 130. Center for Human Genetics, United States
  131. 131. Center for Human Genetic Research, Massachusetts General Hospital, Boston, United States
  132. 132. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
  133. 133. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
  134. 134. Department of Public Health, Faculty of Medicine, University of Split, Croatia
  135. 135. Cardiology, Department of Specialties of Medicine, Geneva University Hospital, 1205 Gen've, Switzerland
  136. 136. Department of Medical Sciences, Cardiovascular Epidemiology, Switzerland
  137. 137. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden
  138. 138. Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
  139. 139. School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, United Kingdom
  140. 140. Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center, Houston, United States
  141. 141. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, United Kingdom
  142. 142. Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, United Kingdom
  143. 143. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
  144. 144. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
  145. 145. Department of Neurology, General Central Hospital, Bolzano, Italy
  146. 146. Department of Neurology, University of Lubeck, Germany
  147. 147. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland
  148. 148. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
  149. 149. Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
  150. 150. Harvard Medical School, Boston, MA, United States
  151. 151. Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
  152. 152. Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria
  153. 153. INSERM U1078, Etablissement Francais du Sang, Brest Cedex, France
  154. 154. Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
  155. 155. John Hunter Hospital, New Lambton, NSW, Australia
  156. 156. New York Academy of Medicine, New York, United States
  157. 157. IRCCS Neuromed, Pozzilli, Isernia, Italy
  158. 158. Molecular and Cellular Therapeutics, Royal College of Surg. in Ireland, Dublin 2, Ireland
  159. 159. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States
  160. 160. Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States
  161. 161. Department of Public Health, United States
  162. 162. Department of Neurology, Bordeaux University Hospital, France
  163. 163. Department of Internal Medicine, Lausanne University Hospital, CHUV, Switzerland
  164. 164. Population Health Research Institute, McMaster University, Hamilton, ON, Canada
  165. 165. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, United Kingdom
  166. 166. Dasman Diabetes Institute, Kuwait
  167. 167. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
  168. 168. Department of Neurosciences and Preventive Medicine, Danube-University Krems, Austria
  169. 169. Division of Cardiovascular Sciences, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, United Kingdom
  170. 170. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, United States
  171. 171. Kaiser Permanent Washington Health Research Institute, Seattle, WA, United States
  172. 172. Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany
  173. 173. Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, Australia
  174. 174. Population Health Research Institute, St george'S, University of London, United Kingdom
  175. 175. Department of Medicine, Columbia University Medical Center, New York, United States
  176. 176. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA, United States
  177. 177. Data Science Institute and Lancaster Medical School, Lancaster University, United Kingdom
  178. 178. Department of Biostatistics, University of Liverpool, United Kingdom

Source: Hypertension Published:2017


Abstract

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation. © 2017 American Heart Association, Inc.
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