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Genetic Analysis of Over 1 Million People Identifies 535 New Loci Associated With Blood Pressure Traits Publisher Pubmed



Evangelou E1, 2 ; Warren HR3, 4 ; Mosenansorena D1 ; Mifsud B3 ; Pazoki R1 ; Gao H1, 5 ; Ntritsos G2 ; Dimou N2 ; Cabrera CP3, 4 ; Karaman I1 ; Ng FL3 ; Evangelou M1, 6 ; Witkowska K3 ; Tzanis E3 Show All Authors
Authors
  1. Evangelou E1, 2
  2. Warren HR3, 4
  3. Mosenansorena D1
  4. Mifsud B3
  5. Pazoki R1
  6. Gao H1, 5
  7. Ntritsos G2
  8. Dimou N2
  9. Cabrera CP3, 4
  10. Karaman I1
  11. Ng FL3
  12. Evangelou M1, 6
  13. Witkowska K3
  14. Tzanis E3
  15. Hellwege JN7
  16. Giri A8
  17. Velez Edwards DR8
  18. Sun YV10, 11
  19. Cho K12, 13
  20. Gaziano JM12, 13
  21. Wilson PWF15
  22. Tsao PS16
  23. Kovesdy CP17
  24. Esko T18, 19
  25. Magi R18
  26. Milani L18
  27. Almgren P20
  28. Boutin T21
  29. Debette S22, 23
  30. Ding J24
  31. Giulianini F25
  32. Holliday EG26
  33. Jackson AU27
  34. Ligao R28
  35. Lin WY29
  36. Luan J30
  37. Mangino M31, 32
  38. Oldmeadow C26
  39. Prins BP33
  40. Qian Y24
  41. Sargurupremraj M23
  42. Shah N34, 35
  43. Surendran P29
  44. Theriault S36, 37
  45. Verweij N19, 38, 39
  46. Willems SM30
  47. Zhao JH30
  48. Amouyel P40
  49. Connell J41
  50. De Mutsert R28
  51. Doney ASF34
  52. Farrall M42, 43
  53. Menni C31
  54. Morris AD44
  55. Noordam R45
  56. Pare G36
  57. Poulter NR46
  58. Shields DC47
  59. Stanton A48
  60. Thom S49
  61. Abecasis G50
  62. Amin N51
  63. Arking DE52
  64. Ayers KL53, 54
  65. Barbieri CM55
  66. Batini C56
  67. Bis JC57
  68. Blake T56
  69. Bochud M58
  70. Boehnke M27
  71. Boerwinkle E59
  72. Boomsma DI60
  73. Bottinger EP61
  74. Braund PS62, 63
  75. Brumat M64
  76. Campbell A65, 66
  77. Campbell H67, 167
  78. Chakravarti A52
  79. Chambers JC1, 5, 68, 69, 70
  80. Chauhan G71
  81. Ciullo M72, 73
  82. Cocca M74
  83. Collins F75
  84. Cordell HJ53
  85. Davies G76, 77
  86. Borst MH78
  87. Geus EJ60
  88. Deary IJ76, 77
  89. Deelen J79
  90. Del Greco M F80
  91. Demirkale CY81
  92. Dorr M82, 83
  93. Ehret GB52, 84
  94. Elosua R85, 86
  95. Enroth S87
  96. Erzurumluoglu AM56
  97. Ferreira T88, 89
  98. Franberg M90, 91, 92
  99. Franco OH93
  100. Gandin I64
  101. Gasparini P64, 74
  102. Giedraitis V94
  103. Gieger C95, 96, 97
  104. Girotto G64, 74
  105. Goel A42, 43
  106. Gow AJ76, 98
  107. Gudnason V99, 100
  108. Guo X101
  109. Gyllensten U87
  110. Hamsten A90, 91
  111. Harris TB102
  112. Harris SE65, 76
  113. Hartman CA103
  114. Havulinna AS104, 105
  115. Hicks AA80
  116. Hofer E106, 107
  117. Hofman A93, 108
  118. Hottenga JJ60
  119. Huffman JE21, 109, 110
  120. Hwang SJ109, 110
  121. Ingelsson E111, 112
  122. James A113, 114
  123. Jansen R115
  124. Jarvelin MR1, 5, 116, 117, 118
  125. Joehanes R109, 119
  126. Johansson A87
  127. Johnson AD109, 120
  128. Joshi PK67, 167
  129. Jousilahti P104
  130. Jukema JW121
  131. Jula A104
  132. Kahonen M122, 123
  133. Kathiresan S19, 38, 124
  134. Keavney BD125, 126
  135. Khaw KT127
  136. Knekt P104
  137. Knight J128
  138. Kolcic I129
  139. Kooner JS5, 69, 70, 130
  140. Koskinen S104
  141. Kristiansson K104
  142. Kutalik Z58, 131
  143. Laan M132
  144. Larson M109
  145. Launer LJ102
  146. Lehne B1
  147. Lehtimaki T133, 134
  148. Liewald DCM76, 77
  149. Lin L84
  150. Lind L135
  151. Lindgren CM42, 89, 136
  152. Liu YM137
  153. Loos RJF30, 61, 138
  154. Lopez LM76, 139, 140
  155. Lu Y61
  156. Lyytikainen LP133, 134
  157. Mahajan A42
  158. Mamasoula C141
  159. Marrugat J85
  160. Marten J21
  161. Milaneschi Y142
  162. Morgan A64
  163. Morris AP42, 143
  164. Morrison AC144
  165. Munson PJ81
  166. Nalls MA145, 146
  167. Nandakumar P52
  168. Nelson CP62, 63
  169. Niiranen T104, 147
  170. Nolte IM148
  171. Nutile T72
  172. Oldehinkel AJ149
  173. Oostra BA51
  174. Oreilly PF150
  175. Org E18
  176. Padmanabhan S66, 151
  177. Palmas W152
  178. Palotie A105, 153, 154
  179. Pattie A77
  180. Penninx BWJH142
  181. Perola M104, 105, 155
  182. Peters A96, 97, 156
  183. Polasek O129, 157
  184. Pramstaller PP80, 158, 159
  185. Nguyen QT81
  186. Raitakari OT160, 161
  187. Ren M162
  188. Rettig R163
  189. Rice K164
  190. Ridker PM25, 165
  191. Ried JS96
  192. Riese H149
  193. Ripatti S105, 166
  194. Robino A74
  195. Rose LM25
  196. Rotter JI101
  197. Rudan I67, 167
  198. Ruggiero D72, 73
  199. Saba Y168
  200. Sala CF55
  201. Salomaa V104
  202. Samani NJ62, 63
  203. Sarin AP105
  204. Schmidt R106
  205. Schmidt H168
  206. Shrine N56
  207. Siscovick D169
  208. Smith AV99, 100
  209. Snieder H148
  210. Sober S132
  211. Sorice R72
  212. Starr JM76, 170
  213. Stott DJ171
  214. Strachan DP172
  215. Strawbridge RJ90, 91
  216. Sundstrom J135
  217. Swertz MA173
  218. Taylor KD101
  219. Teumer A83, 174
  220. Tobin MD56
  221. Tomaszewski M125, 126
  222. Toniolo D55
  223. Traglia M55
  224. Trompet S121, 175
  225. Tuomilehto J176, 177, 178, 179
  226. Tzourio C23
  227. Uitterlinden AG93, 180
  228. Vaez A148, 181
  229. Van Der Most PJ148
  230. Van Duijn CM51
  231. Vergnaud AC1
  232. Verwoert GC93
  233. Vitart V21
  234. Volker U83, 182
  235. Vollenweider P183
  236. Vuckovic D64, 184
  237. Watkins H42, 43
  238. Wild SH185
  239. Willemsen G60
  240. Wilson JF21, 67, 167
  241. Wright AF21
  242. Yao J101
  243. Zemunik T186
  244. Zhang W1, 69
  245. Attia JR26
  246. Butterworth AS29, 187
  247. Chasman DI25, 165
  248. Conen D188, 189
  249. Cucca F190, 191
  250. Danesh J29, 187
  251. Hayward C21
  252. Howson JMM29
  253. Laakso M192
  254. Lakatta EG193
  255. Langenberg C30
  256. Melander O20
  257. Mookkanamori DO28, 194
  258. Palmer CNA34
  259. Risch L195, 196, 197
  260. Scott RA30
  261. Scott RJ26
  262. Sever P130
  263. Spector TD31
  264. Van Der Harst P198
  265. Wareham NJ30
  266. Zeggini E33
  267. Levy D109, 120
  268. Munroe PB3, 4
  269. Newtoncheh C136, 199, 200
  270. Brown MJ3, 4
  271. Metspalu A18
  272. Hung AM201
  273. Odonnell CJ202
  274. Edwards TL7
  275. Psaty BM203, 204
  276. Tzoulaki I1, 2, 5
  277. Barnes MR3, 4
  278. Wain LV56, 63
  279. Elliott P1, 5, 205, 206, 207
  280. Caulfield MJ3, 4

Source: Nature Genetics Published:2018


Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
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