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The Genetics of Blood Pressure Regulation and Its Target Organs From Association Studies in 342,415 Individuals Publisher Pubmed



Ehret GB1, 2 ; Ferreira T3 ; Chasman DI4, 5 ; Jackson AU6, 7 ; Schmidt EM8 ; Johnson T9, 10 ; Thorleifsson G11 ; Luan J12 ; Donnelly LA13 ; Kanoni S14 ; Petersen AK15 ; Pihur V1 ; Strawbridge RJ16, 17 ; Shungin D18, 19, 20 Show All Authors
Authors
  1. Ehret GB1, 2
  2. Ferreira T3
  3. Chasman DI4, 5
  4. Jackson AU6, 7
  5. Schmidt EM8
  6. Johnson T9, 10
  7. Thorleifsson G11
  8. Luan J12
  9. Donnelly LA13
  10. Kanoni S14
  11. Petersen AK15
  12. Pihur V1
  13. Strawbridge RJ16, 17
  14. Shungin D18, 19, 20
  15. Hughes MF21
  16. Meirelles O22
  17. Kaakinen M23
  18. Bouatianaji N24, 25
  19. Kristiansson K26, 27
  20. Shah S28
  21. Kleber ME29
  22. Guo X30
  23. Lyytikainen LP31, 32
  24. Fava C33, 34
  25. Eriksson N35
  26. Nolte IM36
  27. Magnusson PK37
  28. Salfati EL38
  29. Rallidis LS39
  30. Theusch E40
  31. Smith AJP41
  32. Folkersen L16
  33. Witkowska K9, 42
  34. Pers TH43, 44, 45, 46, 47
  35. Joehanes R48
  36. Kim SK49
  37. Lataniotis L14
  38. Jansen R50
  39. Johnson AD48, 51
  40. Warren H9, 42
  41. Kim YJ52
  42. Zhao W53
  43. Wu Y54
  44. Tayo BO55
  45. Bochud M56
  46. Absher D57
  47. Adair LS58
  48. Amin N59
  49. Arking DE1
  50. Axelsson T60
  51. Baldassarre D61, 62
  52. Balkau B63
  53. Bandinelli S64
  54. Barnes MR14, 42
  55. Barroso I65, 66, 67
  56. Bevan S68
  57. Bis JC69
  58. Bjornsdottir G11
  59. Boehnke M6, 7
  60. Boerwinkle E70
  61. Bonnycastle LL71
  62. Boomsma DI72
  63. Bornstein SR73
  64. Brown MJ74
  65. Burnier M75
  66. Cabrera CP9, 42
  67. Chambers JC76, 77, 78
  68. Chang IS79
  69. Cheng CY80, 81, 82
  70. Chines PS71
  71. Chung RH83
  72. Collins FS71
  73. Connell JM84
  74. Doring A85, 86
  75. Dallongeville J87
  76. Danesh J65, 89
  77. De Faire U90
  78. Delgado G29
  79. Dominiczak AF91
  80. Doney ASF13
  81. Drenos F41, 92
  82. Edkins S65
  83. Eicher JD48, 51
  84. Elosua R93
  85. Enroth S94, 95
  86. Erdmann J96, 97
  87. Eriksson P16
  88. Esko T43, 98, 99
  89. Evangelou E76, 100
  90. Evans A21
  91. Fall T101
  92. Farrall M3, 102
  93. Felix JF103
  94. Ferrieres J104
  95. Ferrucci L105
  96. Fornage M106
  97. Forrester T107
  98. Franceschini N108
  99. Franco OH103
  100. Francocereceda A109
  101. Fraser RM110, 111
  102. Ganesh SK112
  103. Gao H76
  104. Gertow K16, 17
  105. Gianfagna F113, 114
  106. Gigante B90
  107. Giulianini F4
  108. Goel A3, 102
  109. Goodall AH115, 116
  110. Goodarzi MO117
  111. Gorski M118, 119
  112. Graler J120
  113. Groves CJ121
  114. Gudnason V122, 123
  115. Gyllensten U94, 95
  116. Hallmans G18
  117. Hartikainen AL124, 125
  118. Hassinen M126
  119. Havulinna AS26
  120. Hayward C127
  121. Hercberg S128
  122. Herzig KH129, 130, 131
  123. Hicks AA132, 268
  124. Hingorani AD28
  125. Hirschhorn JN43, 44, 45, 133
  126. Hofman A103, 134
  127. Holmen J135
  128. Holmen OL135, 136
  129. Hottenga JJ72
  130. Howard P41
  131. Hsiung CA83
  132. Hunt SC137, 138
  133. Ikram MA103, 139, 140
  134. Illig T141, 142, 143
  135. Iribarren C144
  136. Jensen RA69
  137. Kahonen M146, 147
  138. Kang HM6, 7
  139. Kathiresan S45, 148, 149, 150, 151
  140. Keating BJ152, 153
  141. Khaw KT154
  142. Kim YK52
  143. Kim E30
  144. Kivimaki M28
  145. Klopp N141, 142
  146. Kolovou G155
  147. Komulainen P126
  148. Kooner JS77, 78, 156
  149. Kosova G99, 148, 149
  150. Krauss RM157
  151. Kuh D158
  152. Kutalik Z159, 160
  153. Kuusisto J161
  154. Kvaloy K135
  155. Lakka TA126, 162, 163
  156. Lee NR164, 165
  157. Lee IT166, 167
  158. Lee WJ168
  159. Levy D48, 169
  160. Li X30
  161. Liang KW170, 171
  162. Lin H48, 172
  163. Lin L2
  164. Lindstrom J26
  165. Lobbens S173, 174, 175
  166. Mannisto S26
  167. Muller G176
  168. Mullernurasyid M15, 177, 178
  169. Mach F2
  170. Markus HS179
  171. Marouli E14, 180
  172. Mccarthy MI3, 121
  173. Mckenzie CA107
  174. Meneton P181
  175. Menni C182
  176. Metspalu A98
  177. Mijatovic V183
  178. Moilanen L184, 185
  179. Montasser ME186
  180. Morris AD13
  181. Morrison AC187
  182. Mulas A188
  183. Nagaraja R22
  184. Narisu N71
  185. Nikus K189, 190
  186. Odonnell CJ48, 151, 191
  187. Oreilly PF192
  188. Ong KK12
  189. Paccaud F56
  190. Palmer CD43, 45, 193
  191. Parsa A186
  192. Pedersen NL37
  193. Penninx BW194, 195, 196
  194. Perola M26, 27, 98
  195. Peters A86
  196. Poulter N197
  197. Pramstaller PP132, 198, 199
  198. Psaty BM70, 200, 201, 202
  199. Quertermous T38
  200. Rao DC203
  201. Rasheed A204
  202. Rayner NW3, 65, 121
  203. Renstrom F18, 19, 205
  204. Rettig R206
  205. Rice KM207
  206. Roberts R208, 209
  207. Rose LM4
  208. Rossouw J191
  209. Samani NJ115, 116
  210. Sanna S188
  211. Saramies J210
  212. Schunkert H211, 212, 213, 214
  213. Sebert S130, 163, 215
  214. Sheu WHH166, 167, 216
  215. Shin YA52
  216. Sim X6, 7, 217
  217. Smit JH194
  218. Smith AV122, 123
  219. Sosa MX1
  220. Spector TD182
  221. Stancakova A218
  222. Stanton AV219
  223. Stirrups KE14, 220
  224. Stringham HM6, 7
  225. Sundstrom J60
  226. Swift AJ71
  227. Syvanen AC60
  228. Tai ES81, 217, 221
  229. Tanaka T105
  230. Tarasov KV222
  231. Teumer A223
  232. Thorsteinsdottir U11, 123
  233. Tobin MD224
  234. Tremoli E61, 62
  235. Uitterlinden AG103, 225
  236. Uusitupa M226, 227
  237. Vaez A36, 228
  238. Vaidya D229
  239. Van Duijn CM103, 230
  240. Van Iperen EPA231, 232
  241. Vasan RS48, 233, 234
  242. Verwoert GC103
  243. Virtamo J26
  244. Vitart V127
  245. Voight BF235
  246. Vollenweider P236
  247. Wagner A237
  248. Wain LV224
  249. Wareham NJ12
  250. Watkins H3, 102
  251. Weder AB238
  252. Westra HJ239
  253. Wilks R240
  254. Wilsgaard T241, 242
  255. Wilson JF110, 127
  256. Wong TY80, 81, 82
  257. Yang TP14, 243
  258. Yao J30
  259. Yengo L173, 174, 175
  260. Zhang W76, 77
  261. Zhao JH12
  262. Zhu X244
  263. Bovet P56, 245
  264. Cooper RS55
  265. Mohlke KL54
  266. Saleheen D204, 246
  267. Lee JY52
  268. Elliott P76, 247
  269. Gierman HJ49, 248
  270. Willer CJ8, 238, 249
  271. Franke L250
  272. Hovingh GK251
  273. Taylor KD30
  274. Dedoussis G180
  275. Sever P197
  276. Wong A158
  277. Lind L60
  278. Assimes TL38
  279. Njolstad I241, 242
  280. Schwarz PEH73, 252, 253
  281. Langenberg C12
  282. Snieder H36
  283. Caulfield MJ9, 42
  284. Melander O33
  285. Laakso M161
  286. Saltevo J254
  287. Rauramaa R126, 163
  288. Tuomilehto J26, 255, 256, 257
  289. Ingelsson E38, 101
  290. Lehtimaki T31, 32
  291. Hveem K135
  292. Palmas W258
  293. Marz W259, 260
  294. Kumari M28
  295. Salomaa V26
  296. Chen YDI30
  297. Rotter JI30
  298. Froguel P121, 173, 174, 175
  299. Jarvelin MR131, 215, 247, 261
  300. Lakatta EG222
  301. Kuulasmaa K26
  302. Franks PW18, 19, 262
  303. Hamsten A16, 17
  304. Wichmann HE85, 178, 263
  305. Palmer CNA13
  306. Stefansson K11, 123
  307. Ridker PM4, 5
  308. Loos RJF12, 264, 265
  309. Chakravarti A1
  310. Deloukas P14, 266
  311. Morris AP3, 267
  312. Newtoncheh C45, 147, 149
  313. Munroe PB9, 42
Show Affiliations
Authors Affiliations
  1. 1. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, United States
  2. 2. Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
  3. 3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
  4. 4. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States
  5. 5. Harvard Medical School, Boston, MA, United States
  6. 6. Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States
  7. 7. Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States
  8. 8. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States
  9. 9. Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
  10. 10. GlaxoSmithKline, Stevenage, United Kingdom
  11. 11. DeCODE Genetics/Amgen, Inc, Reykjavik, Iceland
  12. 12. MRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
  13. 13. Medical Research Institute, University of Dundee, Ninewells Hospital, Medical School, Dundee, United Kingdom
  14. 14. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
  15. 15. Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
  16. 16. Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
  17. 17. Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
  18. 18. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
  19. 19. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden
  20. 20. Department of Odontology, Umea University, Umea, Sweden
  21. 21. Centre of Excellence for Public Health, Queens University Belfast, Belfast, United Kingdom
  22. 22. Laboratory of Genetics, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, MD, United States
  23. 23. Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom
  24. 24. INSERM UMR 970, Paris Cardiovascular Research Center (PARCC), Paris, France
  25. 25. University Paris-Descartes, Sorbonne Paris Cite, Paris, France
  26. 26. National Institute for Health and Welfare, Helsinki, Finland
  27. 27. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
  28. 28. Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom
  29. 29. Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  30. 30. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States
  31. 31. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
  32. 32. Department of Clinical Chemistry, University of Tampere, School of Medicine, Tampere, Finland
  33. 33. Department of Internal Medicine, University of Lund, Malmo, Sweden
  34. 34. Department of Medicine, University of Verona, Verona, Italy
  35. 35. Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden
  36. 36. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  37. 37. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  38. 38. Department of Medicine, Stanford University, School of Medicine, Stanford, CA, United States
  39. 39. Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece
  40. 40. Children's Hospital, Oakland Research Institute, Oakland, CA, United States
  41. 41. Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom
  42. 42. NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, United Kingdom
  43. 43. Division of Endocrinology, Boston Children's Hospital, Boston, MA, United States
  44. 44. Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, United States
  45. 45. Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge, MA, United States
  46. 46. Novo Nordisk Foundation, Centre for Basic Metabolic Research, Section of Metabolic, Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  47. 47. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  48. 48. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, United States
  49. 49. Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA, United States
  50. 50. Department of Psychiatry, VU University Medical Center, Amsterdam, Netherlands
  51. 51. National Heart, Lung, and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD, United States
  52. 52. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, South Korea
  53. 53. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  54. 54. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  55. 55. Department of Public Health Sciences, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, United States
  56. 56. Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
  57. 57. HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States
  58. 58. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  59. 59. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
  60. 60. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
  61. 61. Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita di Milano, Milan, Italy
  62. 62. Centro Cardiologico Monzino, IRCCS, Milan, Italy
  63. 63. INSERM U1018, Centre for Research in Epidemiology and Population Health, University Paris-Sud, URMS 1018, Villejuif, France
  64. 64. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
  65. 65. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
  66. 66. University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
  67. 67. NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
  68. 68. School of Life Science, University of Lincoln, Joseph Banks Laboratories, Lincoln, United Kingdom
  69. 69. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States
  70. 70. Human Genetics Center, School of Public Health, University of Texas, Health Science Center at Houston, Houston, TX, United States
  71. 71. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, United States
  72. 72. Department of Biological Psychology, VU University, Amsterdam, Netherlands
  73. 73. Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
  74. 74. Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
  75. 75. Nephrology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
  76. 76. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  77. 77. Department of Cardiology, Ealing Hospital, NHS Trust, Southall, United Kingdom
  78. 78. Imperial College Healthcare NHS Trust, London, United Kingdom
  79. 79. National Institute of Cancer Research, National Health Research Institutes, Zhunan Town, Taiwan
  80. 80. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  81. 81. Duke-NUS Graduate Medical School Singapore, Singapore, Singapore
  82. 82. Department of Ophthalmology, National University of Singapore, National University Health System, Singapore, Singapore
  83. 83. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Taiwan
  84. 84. University of Dundee, Ninewells Hospital, Medical School, Dundee, United Kingdom
  85. 85. Institute of Epidemiology i, Helmholtz Zentrum Munchen, Neuherberg, Germany
  86. 86. Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany
  87. 87. INSERM UMR 1167, Lille 2 University, Institut Pasteur Lille, Lille, France
  88. 88. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  89. 89. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  90. 90. Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  91. 91. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
  92. 92. Medical Research Council, Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom
  93. 93. Cardiovascular Epidemiology and Genetics, Institut Hospital Del Mar D'Investigacions Mediques (IMIM), Barcelona, Spain
  94. 94. Department of Immunology, Genetics and Pathology, University of Uppsala, Biomedical Center, Uppsala, Sweden
  95. 95. Science for Life Laboratory, University of Uppsala, Biomedical Center, Uppsala, Sweden
  96. 96. Institut fur Integrative und Experimentelle Genomik, Universiat zu Lubeck, Lubeck, Germany
  97. 97. Deutsches Zentrum fur Herz Kreislauf Forschung (DZHK), Partner Site Hamburg, Lubeck, Kiel, Germany
  98. 98. Estonian Genome Center, University of Tartu, Tartu, Estonia
  99. 99. Broad Institute of mit and Harvard, Cambridge, MA, United States
  100. 100. Department of Hygiene and Epidemiology, University of Ioannina, Medical School, Ioannina, Greece
  101. 101. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
  102. 102. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
  103. 103. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
  104. 104. Toulouse University, School of Medicine, Rangueil University Hospital, INSERM UMR 1027, Toulouse, France
  105. 105. Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States
  106. 106. Institute of Molecular Medicine, University of Texas, Health Science Center at Houston, Houston, TX, United States
  107. 107. Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica
  108. 108. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  109. 109. Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  110. 110. Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
  111. 111. Synpromics, Ltd, Edinburgh, United Kingdom
  112. 112. Department of Cardiology, University of Michigan, Medical School, Ann Arbor, MI, United States
  113. 113. Epidemiology and Preventive Medicine (EPIMED) Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
  114. 114. Department of Epidemiology and Prevention, IRCCS, Istituto Neurologico Mediterraneo (NEUROMED), Pozzilli, Italy
  115. 115. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom
  116. 116. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
  117. 117. Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, United States
  118. 118. Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
  119. 119. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany
  120. 120. Division of Pathobiochemistry, Department of Medicine III, Technische Universitat Dresden, Dresden, Germany
  121. 121. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
  122. 122. Icelandic Heart Association, Kopavogur, Iceland
  123. 123. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  124. 124. Institute of Clinical Medicine/Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
  125. 125. Medical Research Center, Oulu University Hospital, Oulu, Finland
  126. 126. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
  127. 127. Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
  128. 128. UREN, INSERM U557, INRA U1125, CNAM, SMBH, Sorbonne Paris Cite, Universite Paris 13, Bobigny, France
  129. 129. Institute of Biomedicine, University of Oulu, Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
  130. 130. Biocenter Oulu, University of Oulu, Oulu, Finland
  131. 131. Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
  132. 132. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy
  133. 133. Department of Genetics, Harvard Medical School, Boston, MA, United States
  134. 134. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  135. 135. HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway
  136. 136. St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway
  137. 137. Cardiovascular Genetics Division, University of Utah, School of Medicine, Salt Lake City, UT, United States
  138. 138. Department of Genetic Medicine, Weill Cornell Medical College Qatar, Doha, Qatar
  139. 139. Department of Radiology, Erasmus MC, Rotterdam, Netherlands
  140. 140. Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
  141. 141. Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
  142. 142. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
  143. 143. Hannover Medical School, Institute for Human Genetics, Hannover, Germany
  144. 144. Division of Research, Kaiser Permanente, Oakland, CA, United States
  145. 145. Department of Medicine, University of Washington, Seattle, WA, United States
  146. 146. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
  147. 147. Department of Clinical Physiology, University of Tampere, School of Medicine, Tampere, Finland
  148. 148. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, United States
  149. 149. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States
  150. 150. Department of Medicine, Harvard Medical School, Boston, MA, United States
  151. 151. Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States
  152. 152. Division of Transplantation, Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States
  153. 153. Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States
  154. 154. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
  155. 155. 1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
  156. 156. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
  157. 157. Department of Medicine, Children's Hospital, Oakland Research Institute, Oakland, CA, United States
  158. 158. MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom
  159. 159. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
  160. 160. Swiss Institute of Bioinformatics, Lausanne, Switzerland
  161. 161. Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
  162. 162. Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland
  163. 163. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
  164. 164. Office of Population Studies Foundation, Inc., Talamban, Cebu City, Philippines
  165. 165. Department of Anthropology, Sociology and History, University of San Carlos, Talamban, Cebu City, Philippines
  166. 166. Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  167. 167. School of Medicine, National Yang-Ming University, Taipei, Taiwan
  168. 168. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
  169. 169. Population Sciences Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, United States
  170. 170. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
  171. 171. Institute of Clinical Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan
  172. 172. Section of Computational Biomedicine, Department of Medicine, Boston University, School of Medicine, Boston, MA, United States
  173. 173. European Genomic Institute for Diabetes (EGID), Lille, France
  174. 174. CNRS UMR 8199, Lille Pasteur Institute, Lille, France
  175. 175. Lille 2 University, Lille, France
  176. 176. Center for Evidence-Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
  177. 177. Department of Medicine i, University Hospital Großhadern, Ludwig Maximilians University, Munich, Germany
  178. 178. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universitat, Munich, Germany
  179. 179. Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom
  180. 180. Department of Dietetics-Nutrition, Harokopio University, Athens, Greece
  181. 181. INSERM U1142, LIMICS, UMRS 1142, Sorbonne Universites, UPMC Universite Paris 06, Universite Paris 13, Paris, France
  182. 182. Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
  183. 183. Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
  184. 184. Department of Medicine, Kuopio University Hospital, Kuopio, Finland
  185. 185. Unit of General Practice, Oulu University Hospital, Oulu, Finland
  186. 186. Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, MD, United States
  187. 187. Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas, Health Science Center at Houston, Houston, TX, United States
  188. 188. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche, Cittadella Universitaria di Monseratto, Monserrato, Cagliari, Italy
  189. 189. Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
  190. 190. Department of Cardiology, University of Tampere, School of Medicine, Tampere, Finland
  191. 191. National Heart, Lung, and Blood Institute, Division of Cardiovascular Sciences, Bethesda, MD, United States
  192. 192. Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
  193. 193. Genetics and Program in Genomics, Children's Hospital Boston, Boston, MA, United States
  194. 194. Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Amsterdam, Netherlands
  195. 195. Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  196. 196. Department of Psychiatry, Leiden University Medical Centre, Leiden, Netherlands
  197. 197. International Centre for Circulatory Health, Imperial College London, London, United Kingdom
  198. 198. Department of Neurology, General Central Hospital, Bolzano, Italy
  199. 199. Department of Neurology, University of Lubeck, Lubeck, Germany
  200. 200. Department of Epidemiology, University of Washington, Seattle, WA, United States
  201. 201. Department of Health Services, University of Washington, Seattle, WA, United States
  202. 202. Group Health Research Institute, Group Health Cooperative, Seattle, WA, United States
  203. 203. Division of Biostatistics, Washington University, School of Medicine, St. Louis, MO, United States
  204. 204. Center for Non-Communicable Diseases, Karachi, Pakistan
  205. 205. Department of Biobank Research, Umea University, Umea, Sweden
  206. 206. Institute of Physiology, University Medicine Greifswald, Greifswald, Germany
  207. 207. Department of Biostatistics, University of Washington, Seattle, WA, United States
  208. 208. University of Ottawa Heart Institute, Cardiovascular Research Methods Centre Ontario, Ottawa, ON, Canada
  209. 209. Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, ON, Canada
  210. 210. South Karelia Central Hospital, Lappeenranta, Finland
  211. 211. Deutsches Herzzentrum Munchen, Munich, Germany
  212. 212. Technische Universitat Munchen, Munich, Germany
  213. 213. Deutsches Zentrum fur Herz Kreislauf Forschung (DZHK), Munich, Germany
  214. 214. Munich Heart Alliance, Munich, Germany
  215. 215. Center for Lifecourse Health Research, University of Oulu, Oulu, Finland
  216. 216. College of Medicine, National Defense Medical Center, Taipei, Taiwan
  217. 217. Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore
  218. 218. University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
  219. 219. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
  220. 220. Department of Haematology, University of Cambridge, Cambridge, United Kingdom
  221. 221. Department of Medicine, National University of Singapore, National University Health System, Singapore, Singapore
  222. 222. Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, MD, United States
  223. 223. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  224. 224. Department of Health Sciences, University of Leicester, Leicester, United Kingdom
  225. 225. Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands
  226. 226. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
  227. 227. Research Unit, Kuopio University Hospital, Kuopio, Finland
  228. 228. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  229. 229. Johns Hopkins Medical Institutions, Baltimore, MD, United States
  230. 230. Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, Netherlands
  231. 231. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, Netherlands
  232. 232. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands
  233. 233. Section of Preventive Medicine, Department of Medicine, Boston University, School of Medicine, Boston, MA, United States
  234. 234. Cardiology, Department of Medicine, Boston University, School of Medicine, Boston, MA, United States
  235. 235. Department of Systems Pharmacology and Translational Therapeutics, Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States
  236. 236. Department of Internal Medicine, University Hospital Lausanne, Lausanne, Switzerland
  237. 237. Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Strasbourg, France
  238. 238. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, United States
  239. 239. University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  240. 240. Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica
  241. 241. Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway
  242. 242. Department of Clinical Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway
  243. 243. MRC Cancer Unit, University of Cambridge, Cambridge, United Kingdom
  244. 244. Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States
  245. 245. Ministry of Health, Victoria, Seychelles
  246. 246. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States
  247. 247. MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
  248. 248. Enterprise Informatics, Illumina, Inc., Santa Clara, CA, United States
  249. 249. Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States
  250. 250. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  251. 251. Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
  252. 252. Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital, Faculty of Medicine, TU Dresden, Dresden, Germany
  253. 253. German Center for Diabetes Research (DZD), Neuherberg, Germany
  254. 254. Department of Medicine, Central Finland Health Care District, Jyvaskyla, Finland
  255. 255. Dasman Diabetes Institute, Dasman, Kuwait
  256. 256. Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
  257. 257. Centre for Vascular Prevention, Danube University Krems, Krems, Austria
  258. 258. Department of Medicine, Columbia University, New York, NY, United States
  259. 259. Synlab Academy, Synlab Services, Mannheim, Germany
  260. 260. Clinical Institute of Medical, Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
  261. 261. Unit of Primary Care, Oulu University Hospital, Oulu, Finland
  262. 262. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  263. 263. Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany
  264. 264. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  265. 265. Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  266. 266. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
  267. 267. Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom
  268. 268. University of Lubeck, Lubeck, Germany

Source: Nature Genetics Published:2016


Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation. © 2016 Nature America, Inc. All rights reserved.
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