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Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications Publisher



Zadehnajar P1 ; Akbari B1 ; Karbasi S2 ; Mirmusavi MH2
Authors
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Authors Affiliations
  1. 1. Department of Biomaterials, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advance Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2020


Abstract

Designing scaffolds with appropriate mechanical properties is a challenge in tissue engineering. In this study the poly ε-caprolactone (PCL)/gelatin with 1 wt.% of multi-walled carbon nanotubes (MWNTs) fabricated through electrospinning method. The presence of MWNTs led to an increase in the hydrophilicity and tensile strength, while maintaining an appropriate level of porosity percentage. The bioactivity and biodegradation evaluation demonstrated that the scaffolds containing MWNTs presented more bioactivity and slower degradation rate. Cell culture study showed that the nanocomposite scaffolds did not have any cytotoxicity. According to the results, the PCL-gelatin/MWNTs nanocomposite scaffold can be appropriate for cartilage tissue engineering applications. © 2019, © 2019 Taylor & Francis Group, LLC.
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