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Aspirin Resistance Status As Determined by Urinary Thromboxane B 2 (Txb2) Level in Patients With Ischemic Heart Disease and Its Relationship With Severity of Coronary Artery Disease



Ziaie N1 ; Sadeghi M2 ; Akhlaghi A3 ; Pirhaji O4 ; Yaran M4 ; Pourmoghadas M5
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cardiology, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Fellowship of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Coronary artery disease (CAD) and myocardial infarction are the most common cause of mortality and morbidity all over the world. Aspirin resistance is an important part of therapeutic failure in patients who experience several atherosclerotic events despite aspirin therapy. Different studies have reported aspirin resistance between 5-45% all over the world. According to different responses to aspirin therapy in different countries and lack of adequate studies on aspirin resistance in Iran, this study was designed for invitro evaluation of aspirin resistance in Iranian patients. Methods: 170 patients with documented coronary artery stenosis were enrolled in this cross-sectional prospective study. 2 cc urine samples were obtained from all the subjects.Then a questionnaire including questions about ischemic heart disease risk factors (hypertension, diabetes, hyperlipidemia, obesity and smoking) was completed for each patient. Thromboxane B2 level in urine was measured two times for each patient via ELISA method. Data were analyzed via SPSS16 with General Linear Model (Univariate). Gensini modified was used for assessment of severity of coronary arteries involvement (Coronary angiography score). Finding: 75.3% of studied patients were aspirin resistant. There was significant relationship between angiography score and aspirin resistance (P < 0.001). Our results also showed that aspirin resistance is more common in studied women than men (P = 0.003).Significant correlation was observed between diabetes and aspirin resistance in studied subjects (P = 0.023). Conclusion: Our study showed aspirin resistance in a sample of Iranian cardiac patients in Isfahan province, about 75.3% which is higher than other studies in another communities and also aspirin resistance is more common in patients with more severe CAD.
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