Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation

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Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation Publisher Pubmed

Soflaei SS¹ ; Saberikarimian M² ; Baktashian M¹ ; Tajfard M^{3, 4} ; Alimi H⁵ ; Tayefi M^{2, 6} ; Moohebati M⁷ ; Ebrahimi M⁷ ; Kosari N¹ ; Dehghani M⁷ ; Esmaily H⁸ ; Hashemi SM⁹ ; Ferns GA¹⁰ ; Salehi M¹¹ Show All Authors

Soflaei SS¹
Saberikarimian M²
Baktashian M¹
Tajfard M^{3, 4}
Alimi H⁵
Tayefi M^{2, 6}
Moohebati M⁷
Ebrahimi M⁷
Kosari N¹
Dehghani M⁷
Esmaily H⁸
Hashemi SM⁹
Ferns GA¹⁰
Salehi M¹¹
Pasdar A^{1, 12}
Ghayourmobarhan M^{2, 7}

Show Affiliations

1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Health Education and Health Promotion, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
4. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5. Vascular and Endovascular Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6. Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8. Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
9. Department of Cardiology, Chamran Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10. Brighton and Sussex Medical School, Division of Medical Education, Brighton, United Kingdom
11. Department of Genetics, Faculty of Medicine and Genetics Laboratory AL Zahra Hospital, Isfahan University of Medicine, Isfahan, Iran
12. Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, United Kingdom

Source: Acta Cardiologica Published:2023

Abstract

Background: Inflammation has been shown to be an important feature of atherosclerosis. We aimed to assess a profile of inflammatory cytokines and growth factors in patients with established coronary artery disease (CAD), 12 months after stent implantation. Methods: A total of 193 patients with CAD, who were candidates for angiography, 12 months after stent implantation (cases), were compared with 107 patients with CAD, who were candidates for their first angiography (controls). Fasting blood glucose (FBG), triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and high-sensitive C-reactive protein (hs-CRP) were measured using routine methods. The serum concentrations of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, MCP-1, EGF and VEGF were determined using competitive chemiluminescence immunoassays. Results: Serum levels of FBG (p =.002), TG (p =.029) and hs-CRP (p =.005) were significantly lower in cases than controls. The cytokines and growth factor profiles in cases were significantly different from controls. After multivariate analysis, serum levels of IL-2 (p <.001), IL-4 (p =.028) were significantly lower in cases compared with the controls while serum levels of IL-8, TNF-α, MCP-1, EGF and VEGF were significantly higher in the cases (p <.001). Conclusions: In patients with CAD and higher consumption of drug used (statins, aspirin and glucose lowering agents) to mitigate the risk of a secondary event, the level of hs-CRP one year after stent implantation decreased despite of significant higher serum levels of pro- and anti-inflammatory cytokines and growth factors. © 2022 Belgian Society of Cardiology.

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Style	Citing Format
MLA	Soflaei SS, et al.. "Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation." Acta Cardiologica, vol. 78, no. 1, 2023, pp. 80-85.
APA	Soflaei SS, Saberikarimian M, Baktashian M, Tajfard M, Alimi H, Tayefi M, Moohebati M, Ebrahimi M, Kosari N, Dehghani M, Esmaily H, Hashemi SM, Ferns GA, Salehi M, Pasdar A, Ghayourmobarhan M (2023). Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation. Acta Cardiologica, 78(1), 80-85.
Chicago	Soflaei SS, Saberikarimian M, Baktashian M, Tajfard M, Alimi H, Tayefi M, Moohebati M, et al.. "Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation." Acta Cardiologica 78, no. 1 (2023): 80-85.
Harvard	Soflaei SS et al. (2023) 'Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation', Acta Cardiologica, 78(1), pp. 80-85.
Vancouver	Soflaei SS, Saberikarimian M, Baktashian M, Tajfard M, Alimi H, Tayefi M, et al.. Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation. Acta Cardiologica. 2023;78(1):80-85.
BibTex	@article{ author = {Soflaei SS and Saberikarimian M and Baktashian M and Tajfard M and Alimi H and Tayefi M and Moohebati M and Ebrahimi M and Kosari N and Dehghani M and Esmaily H and Hashemi SM and Ferns GA and Salehi M and Pasdar A and Ghayourmobarhan M}, title = {Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation}, journal = {Acta Cardiologica}, volume = {78}, number = {1}, pages = {80-85}, year = {2023} }
RIS	TY - JOUR AU - Soflaei SS AU - Saberikarimian M AU - Baktashian M AU - Tajfard M AU - Alimi H AU - Tayefi M AU - Moohebati M AU - Ebrahimi M AU - Kosari N AU - Dehghani M AU - Esmaily H AU - Hashemi SM AU - Ferns GA AU - Salehi M AU - Pasdar A AU - Ghayourmobarhan M TI - Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation JO - Acta Cardiologica VL - 78 IS - 1 SP - 80 EP - 85 PY - 2023 ER -

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