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Does Lipoprotein (A) Level Have a Predictive Value in Restenosis After Coronary Stenting?



Khosravi A1 ; Pourmoghaddas M2 ; Ziaie F2 ; Enteshari A3 ; Khaledifa A4 ; Bahonar H5
Authors
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Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Chamran Heart Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Isfahan Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2011

Abstract

Objectives: Lipid disorders, lipoproteins, diabetes mellitus, and hypertension are the known risk factors for coronary artery diseases; however, their role is unknown in restenosis after coronary stenting. This study aimed to review the role of these factors, particularly lipoprotein (a) or Lp (a), as a predictive factor for restenosis after coronary stenting with Bare Metal Stent. Methods: In this study, coronary artery stenting was performed on 170 patients. Follow-up was done using coronary angiography in 128 patients, 6 months after conducting angioplasty. Clinical and biochemical characteristics of the patients were collected as prospective method and were compared between the patients with and without restenosis. Results: Restenosis was seen in 46 patients (35.9%). Fasting blood glucose level (FBG) in patients with restenosis was significantly higher than patients without restenosis (102.3 ± 39 mg/dl vs. 84.5 ± 28.9 [OR: 1.02, 95% CI: 1.00-1.04]). Lp (a) levels (OR: 0.54, 95% CI: 0.26-1.10) and other biochemical markers and clinical variables had no correlation with restenosis. Conclusions: Lipoproteins and lipids may not be the underlying cause of restenosis but accurate control of diabetes may improve prognosis after elective coronary stenting.
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