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Propolis As an Adjunctive Therapy for Treatment of Uncomplicated Cystitis in Women: A Randomized Double-Blind Placebo-Controlled Trial Publisher Pubmed



Shekari M1 ; Hadi A2 ; Daabo HMA3 ; Allahyari ZH4 ; Hjazi A5 ; Rafie N6 ; Heidari M7
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
  2. 2. Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
  3. 3. Pharmacy Department, Duhok Technical Institute, Duhok Polytechnic University, Duhok, Iraq
  4. 4. Department of Nursing, Faculty of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran
  5. 5. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia
  6. 6. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Urology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

Source: Phytotherapy Research Published:2024


Abstract

The current research is designed to investigate the effect of propolis supplementation on the clinical manifestations in women suffering from uncomplicated cystitis. In this randomized double-blind, placebo-controlled trial, 120 women with uncomplicated cystitis were selected and randomly assigned into two groups to receive two 500 mg capsules of propolis or placebo daily for 7 days along with ciprofloxacin (250 mg). Clinical symptoms including hematuria, urinary frequency, dysuria, suprapubic pain, and urgency, as well as bacteriuria, were assessed before and after the intervention. After supplementation, participants in the intervention group had significantly fewer days of urinary frequency (p < 0.001), dysuria (p = 0.005), and urgency (p = 0.03). However, there was no significant difference between the two groups regarding hematuria and suprapubic pain (p > 0.05). Furthermore, the severity of bacteriuria decreased significantly in both groups. In conclusion, it seems that propolis supplementation in women with uncomplicated cystitis could improve urinary frequency, dysuria, and urgency. However, further clinical trials should be conducted to fully understand the effects of propolis in women suffering from uncomplicated cystitis. © 2023 John Wiley & Sons Ltd.
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