Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Oxidative Balance and Mental Health: Exploring the Link Between Prooxidant-Antioxidant Balance and Depression in Hypertensive and Normotensive Individuals, Accounting for Sex Differences Publisher Pubmed



Kamrani F1 ; Kachouei AA2 ; Fereydouni N3, 4 ; Tanbakuchi D5 ; Esmaily H5, 6 ; Moohebati M7, 8 ; Mahaki H9 ; Rezaee A10 ; Darroudi S9 ; Ghayourmobarhan M1 ; Ferns GA1, 11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. No communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  4. 4. Department of Tissue Engineering, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  5. 5. Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Metabolic syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Cardiovascular, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Vascular and Endovascular Surgery Research Center, Mashhad University of medical sciences, Mashhad, Iran
  10. 10. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  11. 11. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, U

Source: Journal of Affective Disorders Published:2024


Abstract

Background: Existing studies have suggested a link between oxidative stress levels and depression. Additionally, factors such as gender and conditions like hypertension have been shown to influence oxidative stress. This ten-year follow-up cohort study aims to examine the association between prooxidant-antioxidant balance (PAB) and the onset of depression and its symptoms in both hypertensive and normotensive individuals, while considering gender differences. Methods: The data for this study was obtained from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, a cohort study conducted in eastern Iran. Serum PAB levels were measured in 1702 hypertensive and 4096 normotensive individuals aged 35 to 65 years. After ten years, the participants' depression status was evaluated using the Beck questionnaire, and depression symptoms were investigated using the BDI-II structural model, which includes somatic, affective, and cognitive symptoms. Result: The analysis indicates that in hypertensive male participants, the highest tertile of PAB is associated with an increased risk of depression (β: 1.22, 95 % CI: −0.046, 2.485; P = 0.059) and symptoms of depression, including cognitive (β: 2.937, 95 % CI: 0.511, 5.362; P = 0.018) and somatic (β: 2.654, 95 % CI: 0.37, 4.939; P = 0.023) symptoms. However, there was no significant association between affective symptoms and PAB tertiles. Additionally, there was no significant link between depression and depressive symptoms in female hypertensive and normotensive individuals. Conclusion: In male hypertensive patients, but not in normotensive individuals of both genders and hypertensive women, depression and its associated symptoms, including somatic and cognitive symptoms, are associated with elevated levels of oxidative stress, as evidenced by higher serum PAB values. PAB is not associated with affective symptoms. Future studies should focus on the gender-specific nature of this relationship and work to clarify its underlying mechanisms. © 2024 Elsevier B.V.
Related Docs
View other Related Docs
1. Dietary Pro-Oxidant Score (Pos) and Cardio-Metabolic Panel Among Obese Individuals: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
2. Adherence to a Healthy Dietary Pattern Is Associated With Less Severe Depressive Symptoms Among Adolescent Girls, Psychiatry Research (2019)
3. Relationship Between Depression and Apolipoproteins a and B: A Case-Control Study, Clinics (2011)
4. Association Between Psychosocial Distress With Cardio Metabolic Risk Factors and Liver Enzymes in a Nationally-Representative Sample of Iranian Children and Adolescents: The Caspian-Iii Study, Journal of Diabetes and Metabolic Disorders (2014)
5. The Oxidative Status and Na+/K+-Atpase Activity in Obsessive-Compulsive Disorder: A Case Control Study, BioMed Research International (2024)
6. The Structural Equation Modeling of the Relationship Between Depression and Blood Pressure With the Mediating Role of Nutritional Habits in the Elderly, Journal of Health System Research (2023)
7. Enhanced Plasma Level of Lipid Peroxidation in Iranians Could Be Improved by Antioxidants Supplementation, European Journal of Clinical Nutrition (1997)
8. Evaluation of the Relationship Between Depression, Anxiety, and Stress With Hypertension: Results of a Health Study in Yazd, Iran, Journal of Biostatistics and Epidemiology (2019)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (15)
Masoumeh Sadeghi (13)
Other Related Docs
9. The Association Between Stress Levels and Food Consumption Among Iranian Population, Archives of Iranian Medicine (2013)
10. Total Antioxidant Capacity and Malondialdehyde in Depressive Rotational Shift Workers, Journal of Environmental and Public Health (2013)
11. Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects With Cardiovascular Disease Risk Factors, Iranian Journal of Basic Medical Sciences (2012)
12. The Association Between Hypertriglyceridemic Waist Phenotype, Menopause, and Cardiovascular Risk Factors, Archives of Iranian Medicine (2013)
13. Evaluation of Relationship Between Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients, ARYA Atherosclerosis (2014)
14. Is There Any Association of Anxiety-Depressive Symptoms With Vascular Endothelial Function or Systemic Inflammation?, Journal of Research in Medical Sciences (2013)
15. An Unhealthy Plant-Based Diet Increases Risk of Hypertension But Not Framingham Risk Score in Adults, Current Developments in Nutrition (2023)
16. Association of Expression of Selenoprotein P in Mrna and Protein Levels With Metabolic Syndrome in Subjects With Cardiovascular Disease: Results of the Selenegene Study, Journal of Gene Medicine (2017)
17. Factors Affecting Uncontrolled Hypertension in an Iranian Population, Iranian Heart Journal (2013)
18. The Association of Birth Weight With Cardiovascular Risk Factors and Mental Problems Among Iranian School-Aged Children: The Caspian-Iii Study, Nutrition (2014)
19. Is Prehypertension a Risk Factors for Cardiovascular Diseases Among Iranian Women?, Journal of Research in Medical Sciences (2012)
20. Incident Hypertension and Its Predictors: The Isfahan Cohort Study, Journal of Hypertension (2014)
21. Association of Dietary Total Antioxidant Capacity to Anthropometry in Healthy Women: A Cross-Sectional Study, Nutrition (2020)
22. Association of Dietary Phytochemical Index and Mental Health in Women: A Cross-Sectional Study, British Journal of Nutrition (2019)
23. Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10-18 Years Old, Clinical Chemistry (2007)
24. Do Any Kinds of Perceived Stressors Lead to Hypertension? a Longitudinal Cohort Study, Hypertension Research (2022)
25. Dietary Total Antioxidant Capacity in Relation to Stroke Among Iranian Adults, Nutritional Neuroscience (2020)
26. Oxidative Stress and Hypertension: Possibility of Hypertension Therapy With Antioxidants, Journal of Research in Medical Sciences (2014)
27. How Does the Impact of a Community Trial on Cardio-Metabolic Risk Factors Differ in Terms of Gender and Living Area? Findings From the Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2012)
28. Dietary Total Antioxidant Capacity in Relation to Depression and Anxiety in Iranian Adults, Nutrition (2019)
29. Comparing the Risk of Cardiovascular Diseases and All-Cause Mortality in Four Lifestyles With a Combination of High/Low Physical Activity and Healthy/Unhealthy Diet: A Prospective Cohort Study, International Journal of Behavioral Nutrition and Physical Activity (2022)
30. Psychological Status and Quality of Life in Relation to the Metabolic Syndrome: Isfahan Cohort Study, International Journal of Endocrinology (2012)
31. The Relationship Between Weight and Cvd Risk Factors in a Sample Population From Central Iran (Based on Ihhp), ARYA Atherosclerosis (2012)
32. The Effects of Consuming a Low-Fat Yogurt Fortified With Nano Encapsulated Vitamin D on Serum Pro-Oxidant-Antioxidant Balance (Pab) in Adults With Metabolic Syndrome; a Randomized Control Trial, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2021)
33. Dietary and Biochemical Characteristics Associated With Normal-Weight Obesity, International Journal for Vitamin and Nutrition Research (2019)
34. High Blood Pressure and Associated Cardiovascular Risk Factors in Iran: Isfahan Healthy Heart Programme, Medical Journal of Malaysia (2004)
35. Relationship Between Metabolic Syndrome and Its Components With Psychological Distress, International Journal of Endocrinology (2014)
36. Prooxidant-Antioxidant Balance in Patients With Systemic Lupus Erythematosus and Its Relationship With Clinical and Laboratory Findings, Autoimmune Diseases (2016)
37. Resistin and Prooxidant-Antioxidant Balance: Markers to Discriminate Acute Coronary Syndrome From Stable Angina, ARYA Atherosclerosis (2020)
38. Nationwide Survey of Prevalence and Risk Factors of Prehypertension and Hypertension in Iranian Adults, Journal of Hypertension (2008)
39. Correlation Between Hypertension, C-Reactive Protein and Serum Uric Acid With Psychological Well-Being, Iranian Red Crescent Medical Journal (2014)
40. Selenium Supplementation and Oxidative Stress: A Review, PharmaNutrition (2021)
41. Prevalence of High Blood Pressure in Iranian Adults Based on the 2017 Acc/Aha Guideline, Medical Journal of the Islamic Republic of Iran (2019)
42. Expression of Bcl-2 and Bax Genes in Peripheral Blood Lymphocytes of Depressed and Nondepressed Individuals, Journal of Research in Medical Sciences (2019)
43. Antioxidant Status and Risk of Coronary Artery Disease, Nutrition and Food Science (2019)
44. Does the Impact of Metabolic Syndrome on Cardiovascular Events Vary by Using Different Definitions? Chronic Disease Epidemiology, BMC Public Health (2015)
45. Association of Serum Vitamin D and Total Antioxidant Capacity Levels With Stress and Anxiety in Young Female Students, Iranian Journal of Psychiatry and Behavioral Sciences (2017)
46. Anxiety But Not Depression Is Associated With Metabolic Syndrome: The Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2017)
47. Dietary Phytochemical Index in Relation to Risk of Stroke: A Case-Control Study, Nutritional Neuroscience (2022)
48. Dietary Fiber Intake, Depression, and Anxiety: A Systematic Review and Meta-Analysis of Epidemiologic Studies, Nutritional Neuroscience (2023)
49. Gender Differences in Risk Factors and Outcomes After Cardiac Rehabilitation, Acta Cardiologica (2008)
50. Relationship Between Antioxidant Status and Attention Deficit Hyperactivity Disorder Among Children, International Journal of Preventive Medicine (2019)