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Blood Compatibility and Cell Response Improvement of Poly Glycerol Sebacate/Poly Lactic Acid Scaffold for Vascular Graft Applications Publisher Pubmed



Mokhtari N1 ; Zargar Kharazi A2, 3
Authors
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Authors Affiliations
  1. 1. Tissue Engineering Group, Department of Materials Engineering, Islamic Azad University Najafabad Branch, Isfahan, Iran
  2. 2. Biomaterials Nanotechnology and Tissue Engineering faculty, School of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Biomedical Materials Research - Part A Published:2021


Abstract

Plasma surface modification is one of the new methods for improving the surface properties of the scaffold and accelerating tissue regeneration. The aim of this study was to create poly glycerol sebacate/poly lactic acid (PGS/PLA) composite scaffold by electrospun method and modified the scaffold by oxygen plasma for use as a vascular graft. Plasma surface modified PGS/PLA scaffold morphology study showed relatively uniform fibers with an average diameter of 637 ± 149.4 nm and porosity of 82%. The mechanical evaluation of the PGS/PLA scaffold showed properties close to the natural vessels. Atomic force microscopy images exhibited an increase in the roughness of the scaffold after plasma surface modification; however, hemocompatibility studies revealed that it had no adverse effect on blood compatibility. Wettability studies revealed the superhydrophilic property of the modified scaffold (contact angle near to zero). Besides, the human umbilical vein endothelial cells proliferation and adhesion were improved significantly. Obtaining mechanical properties near to the natural vessels due to the suitable composition and significant improvement in blood compatibility and cell growth make the modified PGS/PLA composite a suitable candidate for vascular tissue regeneration. © 2021 Wiley Periodicals LLC.
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