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Fabrication of a Tri-Layer Scaffold With Dual Release of Heparin and Prp for Tissue Engineering of Small‐Diameter Blood Vessels Publisher



Zargar Kharazi A1, 2 ; Ghebleh A1 ; Shariati L1, 3
Authors
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Authors Affiliations
  1. 1. Biomaterials Nanotechnology and Tissue Engineering Faculty, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2024


Abstract

A tri-layer scaffold was fabricated according to functionally graded materials (FGM) theory from poly(glycerol sebcate)/poly(L-lactic acid) blend by the increasing polylactic acid ratio from the inner to the outer layer. Heparin and platelet-rich plasma were loaded in separate layers to achieve proper remodeling and patency. The scaffold showed a linear degradation trend. The elastic modulus was 13.8 ± 1.11 Mpa that was in the favorable range for constructing artificial vessels. The integrity of the layers was preserved due to its FGM structure. The scaffold showed full blood compatibility by minimal platelet adhesion and hemolysis due to relatively slow release of Heparin. © 2023 Taylor & Francis Group, LLC.
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