Isfahan University of Medical Sciences

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Features and Roles of T Helper 9 Cells and Interleukin 9 in Immunological Diseases Publisher Pubmed



Yazdani R1 ; Shapoori S2 ; Rezaeepoor M2 ; Sanaei R3 ; Ganjalikhanihakemi M2 ; Azizi G4, 5 ; Rae W6 ; Aghamohammadi A1 ; Rezaei N1, 7, 8
Authors

Source: Allergologia et Immunopathologia Published:2019


Abstract

T helper 9 (T H 9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed T H 9 cells. Recently, the role of T H 9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning T H 9 cells and IL-9 as well as their roles in disease. These insights suggest that T H 9 cells are a future target for therapeutic intervention. © 2018 SEICAP