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Features and Roles of T Helper 9 Cells and Interleukin 9 in Immunological Diseases Publisher Pubmed



Yazdani R1 ; Shapoori S2 ; Rezaeepoor M2 ; Sanaei R3 ; Ganjalikhanihakemi M2 ; Azizi G4, 5 ; Rae W6 ; Aghamohammadi A1 ; Rezaei N1, 7, 8
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran, Iran
  4. 4. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Immunology, MP8, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, Hampshire, United Kingdom
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  8. 8. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Allergologia et Immunopathologia Published:2019


Abstract

T helper 9 (T H 9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed T H 9 cells. Recently, the role of T H 9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning T H 9 cells and IL-9 as well as their roles in disease. These insights suggest that T H 9 cells are a future target for therapeutic intervention. © 2018 SEICAP
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