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Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency? Publisher Pubmed



Tak Manesh A1 ; Azizi G2, 3 ; Heydari A3 ; Kiaee F3 ; Shaghaghi M3 ; Hosseinkhannazer N4 ; Yazdani R5 ; Abolhassani H3, 6 ; Aghamohammadi A3
Authors

Source: Allergologia et Immunopathologia Published:2017


Abstract

Common variable immunodeficiency (CVID) is a diagnostic category of primary immunodeficiency (PID) which may present with heterogeneous disorders including recurrent infections, autoimmunity, granulomatous diseases, lymphoid and other types of malignancies. Generally, the incidence of malignancy in CVID patients is around 1.5–20.7% and usually occurs during the 4th–6th decade of life. Non-Hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumours of stomach, breast, bladder and cervix. The exact pathological mechanisms for cancer development in CVID are not fully determined; however, several mechanisms including impaired genetic stability, genetic predisposition, immune dysregulation, impaired clearance of oncogenic viruses and bacterial infections, and iatrogenic causes have been proposed to contribute to the high susceptibility of these patients to malignancies. © 2017
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