Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Factors Affecting Mortality in Covid-19-Associated Pulmonary Aspergillosis: An International Id-Iri Study Publisher



Sahin M1 ; Yilmaz M1 ; Mert A1 ; Emecen AN2 ; Rahman S Al Maslamani MA3 ; Mahmoud A Hashim S3 ; Ittaman AV3 ; Wadi Al Ramahi J4 ; Gergely Szabo B5 ; Konopnicki D6 ; Baskol Elik D7 ; Lakatos B5 ; Sipahi OR7 ; Khedr R8 Show All Authors
Authors
  1. Sahin M1
  2. Yilmaz M1
  3. Mert A1
  4. Emecen AN2
  5. Rahman S Al Maslamani MA3
  6. Mahmoud A Hashim S3
  7. Ittaman AV3
  8. Wadi Al Ramahi J4
  9. Gergely Szabo B5
  10. Konopnicki D6
  11. Baskol Elik D7
  12. Lakatos B5
  13. Sipahi OR7
  14. Khedr R8
  15. Jalal S9
  16. Pshenichnaya N10
  17. Magdalena DI11
  18. Elkholy A12
  19. Khan EA13
  20. Alkan S14
  21. Hakamifard A15
  22. Sincan G16
  23. Esmaoglu A17
  24. Makek MJ18, 19
  25. Gurbuz E20
  26. Liskova A21
  27. Albayrak A22
  28. Stebel R23
  29. Unver Ulusoy T24
  30. Ripon RK25
  31. Moroti R26, 27
  32. Dascalu C26
  33. Rashid N13
  34. Cortegiani A28
  35. Bahadir Z29
  36. Erdem H30
Show Affiliations
Authors Affiliations
  1. 1. Istanbul Medipol University, Infectious Diseases and Clinical Microbiology, Istanbul, Turkey
  2. 2. Dokuz Eylul University, Research and Application Hospital, Izmir, Turkey
  3. 3. Communicable Disease Center / Infectious Disease – Medicine Department, Hamad Medical Corporation, Doha, Qatar
  4. 4. University of Jordan, School of Medicine, Amman, Jordan
  5. 5. South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Budapest, Hungary
  6. 6. Universite Libre de Bruxelles, Saint-Pierre University Hospital, Infectious Diseases Department, Bruxelles, Belgium
  7. 7. Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey
  8. 8. National Cancer Institute - Cairo University / Children's Cancer Hospital Egypt, Department of Pediatric Oncology, Cairo, Egypt
  9. 9. Salmaniya Medical Complex, Manama, Bahrain
  10. 10. Central Research Institute of Epidemiology, Department of Infectious Diseases, Moscow, Russian Federation
  11. 11. Ovidius University of Constanta, Clinical Infectious Diseases Hospital, Constanta, Romania
  12. 12. Cairo University, Faculty of Medicine, Department of Clinical Pathology, Cairo, Egypt
  13. 13. Shifa Tameer-e-Millat University and Shifa International Hospital, Infectious Diseases Division, Islamabad, Pakistan
  14. 14. Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Canakkale, Turkey
  15. 15. Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  16. 16. Ataturk University, Faculty of Medicine, Department of Haematology, Erzurum, Turkey
  17. 17. Erciyes University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Kayseri, Turkey
  18. 18. University of Zagreb School of Medicine, Zagreb, Croatia
  19. 19. Clinic for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia
  20. 20. University of Health Sciences, Van Training and Research Hospital, Van, Turkey
  21. 21. Hospital Nitra, Department of Clinical Microbiology, St. Elizabeth University of Health and Social Sciences Bratislava, Slovakia
  22. 22. Ataturk University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Erzurum, Turkey
  23. 23. University Hospital Brno and Faculty of Medicine, Masaryk University, Department of Infectious Diseases, Brno, Czech Republic
  24. 24. University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Ankara, Turkey
  25. 25. Jahangirnagar University, Department of Public Health and Informatics, Savar, Dhaka, Bangladesh
  26. 26. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  27. 27. National Institute for Infectious Diseases Matei Bals, Bucharest, Romania
  28. 28. Department of Surgical Oncological and Oral Science (Di.Chir.On.S.), University of Palermo. Department of Anesthesia Intensive Care and Emergency, University Hospital Policlinico “Paolo Giaccone”, Palermo, Italy
  29. 29. Istanbul Medipol University Medical School, Istanbul, Turkey
  30. 30. University of Health Sciences, Gulhane School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey

Source: Heliyon Published:2024


Abstract

Background: This study aimed to identify factors that influence the mortality rate of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA). Methods: In this cross-sectional study, data from 23 centers across 15 countries, spanning the period of March 2020 to December 2021, were retrospectively collected. The study population comprised patients who developed invasive pulmonary aspergillosis while being treated for COVID-19 in the intensive care unit. Cox regression and decision tree analyses were used to identify factors associated with mortality in patients with CAPA. Results: A total of 162 patients (males, 65.4 %; median age: 64 [25th–75th: 54.0–73.8] years) were included in the study, of whom 113 died during the 90-day follow-up period. The median duration from CAPA diagnosis to death was 12 (25th–75th: 7–19) days. In the multivariable Cox regression model, an age of ≥65 years (hazard ratio [HR]: 2.05, 95 % confidence interval [CI]: 1.37–3.07), requiring vasopressor therapy at the time of CAPA diagnosis (HR: 1.80, 95 % CI: 1.17–2.76), and receiving renal replacement therapy at the time of CAPA diagnosis (HR: 2.27, 95 % CI: 1.35–3.82) were identified as predictors of mortality. Decision tree analysis revealed that patients with CAPA aged ≥65 years who received corticosteroid treatment for COVID-19 displayed higher mortality rates (estimated rate: 1.6, observed in 46 % of patients). Conclusion: This study concluded that elderly patients with CAPA who receive corticosteroids are at a significantly higher risk of mortality, particularly if they experience multiorgan failure. © 2024
Experts (# of related papers)
Other Related Docs
15. Epidemiological Features of Covid-19 in Iran, Journal of Research in Medical Sciences (2022)