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Health Risk Assessment of Exposure to Triclosan in Pregnant Women Using Monte Carlo Simulation Techniques: Based on Biomonitoring Data Publisher Pubmed



Attarian E1, 2 ; Mohammadi F2, 3 ; Ebrahimpour K2, 3 ; Moazeni M1, 2 ; Maracy M3, 4 ; Ebrahimi A2, 3 ; Kelishadi R5
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Environmental Science and Health, Part C: Toxicology and Carcinogenesis Published:2023


Abstract

This study aimed to assess the triclosan (TCS) health risk in an Iranian pregnant women sample by Monte Carlo simulation (MCS). The urinary TCS of 99 women after the 28th week of pregnancy was detected by gas chromatography/mass spectrometry detector (GC/MS), and the MCS model implemented a health risk assessment. The corresponding hazard quotient (HQ) and the sensitivity analysis were calculated. TCS was measured in 100% of the urine samples with a median concentration of 2.89 µg/L. The median of HQ was obtained at 1.93 × 10−4. The TCS exposure risk in the studied population was lower than the allowable limit. A comparison between HQ values in the two weight subgroups of pregnant women showed that the risk level is almost equal, and there was minimal health risk in pregnant women from exposure to TCS. © 2023 Taylor & Francis Group, LLC.
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