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Sardasht-Iran Cohort Study of Chemical Warfare Victims: Design and Methods Pubmed



Ghazanfari T1, 2 ; Faghihzadeh S3 ; Aragizadeh H4 ; Soroush MR5 ; Yaraee R1, 2 ; Hassan ZM3, 6 ; Foroutan A7, 9 ; Vaezmahdavi MR8 ; Javadi MA9 ; Moaiedmohseni S10 ; Azizi F9, 11 ; Panahi Y12 ; Mostafaie A13 ; Ghasemi H14 Show All Authors
Authors
  1. Ghazanfari T1, 2
  2. Faghihzadeh S3
  3. Aragizadeh H4
  4. Soroush MR5
  5. Yaraee R1, 2
  6. Hassan ZM3, 6
  7. Foroutan A7, 9
  8. Vaezmahdavi MR8
  9. Javadi MA9
  10. Moaiedmohseni S10
  11. Azizi F9, 11
  12. Panahi Y12
  13. Mostafaie A13
  14. Ghasemi H14
  15. Shams J15, 17
  16. Pourfarzam S16
  17. Jalalinadoushan MR5, 15, 17
  18. Fallahi F18
  19. Ebtekar M3, 6
  20. Davoudi SM12
  21. Ghazanfari Z3, 19
  22. Ardestani SK20
  23. Shariatpanahi S21
  24. Moin A22
  25. Rezaei A23, 25
  26. Kariminia A24, 26
  27. Ajdary S24, 26
  28. Mahmoudi M25
  29. Roshan R26
  30. Ghaderi S27
  31. Babai M4
  32. Naghizadeh MM2
  33. Ghanei M12
  34. Tebyanian S3
  35. Saadati M3
  36. Mansourian M3
  37. Jalaei S3
  38. Merasizadeh J4
  39. Heidari MR4
  40. Karami G4
  41. Ghassemibroumand M9
  42. Zaeri F9
  43. Chalabi M13
  44. Kiani S13
  45. Ghanbari F13
  46. Parvaneh S13
  47. Mahboudi F24
  48. Askari N24
  49. Darabi H24
  50. Riazi F24
  51. Rastin M25
  52. Zamani S25
  53. Tabasi N25
  54. Andalib A23
  55. Gharagozloo M23
  56. Giasi Z23
  57. Habibiashtyani N27
  58. Heidari F27
  59. Tolouei R27
  60. Mohamadpanahi S27
  61. Ghaderi R27
  62. Molaian A27
  63. Maroufiaghdam F27
  64. Maroufpour S27
  65. Mowafighi M27
  66. Alipour S27
  67. Barzigar M27
  68. Shamami G27
  69. Mahmoudnejhad S27
  70. Meykhasteh A27
  71. Khateri S5
  72. Amini R5
  73. Emadi N5
  74. Falahati F5
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  2. 2. Immunoregulation Research Center, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  3. 3. Department of Biostatistics, Tarbiat Moddarres University, Tehran, Iran
  4. 4. Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
  6. 6. Department of Immunology, Tarbiat Moddarres University, Tehran, Iran
  7. 7. Department of Physiology, Shahed Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Physiology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  9. 9. Ophthalmology Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Medical Research Center, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  11. 11. Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
  13. 13. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  14. 14. Department of Ophthalmology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  15. 15. Department of Oncology and Hematology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  16. 16. Department of Internal Medicine, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  17. 17. Department of Oncology and Hematology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  18. 18. Department of Cardiology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  19. 19. Department of Health, Ilam University of Medical Sciences, Ilam, Iran
  20. 20. Department of Immunology, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  21. 21. Department of Rheumatology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  22. 22. Department of Dermatology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  23. 23. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
  24. 24. Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
  25. 25. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  26. 26. Department of Psychology, Shahed University, Tehran, P.O. Box: 14155-7435, Iran
  27. 27. Chemical Victims' Clinic of Sardasht, Sardasht, West Azarbaijan Province, Iran

Source: Archives of Iranian Medicine Published:2009


Abstract

Background: Insights into long-term clinical consequences of sulfur mustard have emerged from some investigations but less is known about the basic and molecular mechanisms of these complications. Sardasht-Iran Cohort Study is a comprehensive historical cohort study on Sardasht chemical victims' population which was designed to find out the long-term complications of sulfur mustard exposure and the basic mechanisms underlying clinical manifestations. This paper describes the design and methodology of Sardasht-Iran Cohort Study. Methods: In Sardasht-Iran Cohort Study, 500 individuals including 372 subjects from Sardasht, as the exposed group, and 128 subjects from Rabat, as the unexposed age-matched control group were evaluated. The exposed group was divided into two groups based on the severity of clinical complications at the time of exposure. Different samples including blood, sputum, saliva, tear, urine, and semen were collected for immunologic, hematologic, biochemical, and other laboratory analysis. Data were gathered from medical records, clinical examinations, laboratory tests, and questionnaires for psychological and lifestyle situations. Conclusion: The important distinctions setting this study apart from the previous ones are discussed. The Sardasht-Iran Cohort Study provides important information on various aspects of long- term consequences of sulfur mustard exposure. This database will provide a better position to suggest guidelines for the diagnosis, treatment, and prevention of delayed complications in the patients exposed to sulfur mustard.
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