Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study

Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study Publisher Pubmed

Ghazanfari T^{1, 2} ; Yaraee R^{1, 2} ; Kariminia A³ ; Ebtekar M⁴ ; Faghihzadeh S⁵ ; Vaezmahdavi MR⁶ ; Rezaei A⁷ ; Vojgani M⁸ ; Soroush MR⁹ ; Kermanijalilvand A¹ ; Mohammadi P¹⁰ ; Foroutan A¹¹ ; Hassan ZM⁴

Show Affiliations

1. Immunoregulation Research Center, Shahed University, Tehran, Iran
2. Department of Immunology, Shahed University, Tehran, Iran
3. Department of Pediatrics, University of British Columbia, Vancouver, Canada
4. Department of Immunology, Tarbiat Moddarres University, Tehran, Iran
5. Department of Biostatistics, Tarbiat Moddarres University, Tehran, Iran
6. Department of Physiology, Shahed University, Tehran, Iran
7. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
8. Department of Immunology, Medical faculty, Tehran University of Medical Science, Tehran, Iran
9. Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
10. Department of Biology, Alzahra University, Tehran, Iran
11. Department of Physiology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Source: International Immunopharmacology Published:2009

Abstract

The serum levels of four important and well characterized inflammatory chemokines including MCP-1/CCL2, RANTES/CCL5, IL-8/CXCL8 and Fractalkine/CX3CL1 were evaluated in sulfur mustard (SM) exposed Iranian population 20 years after exposure. In this historical cohort study 372 SM exposed participants from Sardasht, and 128 unexposed participants as controls were studied. The serum concentrations of chemokines were measured by a sandwich ELISA technique. The serum concentrations in the exposed comparing to the control group were 201.86 vs 180.60 pg/ml (p = 0.002), for MCP-1/CCL2, 1182.6 vs 1393.1 pg/ml (p = 0.021) for RANTES/CCL5, 12.61 vs 15 pg/ml (p = 0.002) for IL-8/CXCL8 and 0.696 vs 0.0648 (p = 0.413) for Fractalkine/CX3CL1. In conclusion, elevated levels of MCP-1/CCL2 may suggest an anti inflammatory response and decreased levels of IL-8/CXCL8 and RANTES/CCL5 may represent a different pathophysiology and diverse molecular mechanisms involved in long term clinical manifestations of SM exposure. However, further prospect into their role in the pathogenesis of SM remains to be done. © 2009 Elsevier B.V. All rights reserved.

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Style	Citing Format
MLA	Ghazanfari T, et al.. "Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study." International Immunopharmacology, vol. 9, no. 13-14, 2009, pp. 1471-1476.
APA	Ghazanfari T, Yaraee R, Kariminia A, Ebtekar M, Faghihzadeh S, Vaezmahdavi MR, Rezaei A, Vojgani M, Soroush MR, Kermanijalilvand A, Mohammadi P, Foroutan A, Hassan ZM (2009). Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study. International Immunopharmacology, 9(13-14), 1471-1476.
Chicago	Ghazanfari T, Yaraee R, Kariminia A, Ebtekar M, Faghihzadeh S, Vaezmahdavi MR, Rezaei A, et al.. "Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study." International Immunopharmacology 9, no. 13-14 (2009): 1471-1476.
Harvard	Ghazanfari T et al. (2009) 'Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study', International Immunopharmacology, 9(13-14), pp. 1471-1476.
Vancouver	Ghazanfari T, Yaraee R, Kariminia A, Ebtekar M, Faghihzadeh S, Vaezmahdavi MR, et al.. Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study. International Immunopharmacology. 2009;9(13-14):1471-1476.
BibTex	@article{ author = {Ghazanfari T and Yaraee R and Kariminia A and Ebtekar M and Faghihzadeh S and Vaezmahdavi MR and Rezaei A and Vojgani M and Soroush MR and Kermanijalilvand A and Mohammadi P and Foroutan A and Hassan ZM}, title = {Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study}, journal = {International Immunopharmacology}, volume = {9}, number = {13-14}, pages = {1471-1476}, year = {2009} }
RIS	TY - JOUR AU - Ghazanfari T AU - Yaraee R AU - Kariminia A AU - Ebtekar M AU - Faghihzadeh S AU - Vaezmahdavi MR AU - Rezaei A AU - Vojgani M AU - Soroush MR AU - Kermanijalilvand A AU - Mohammadi P AU - Foroutan A AU - Hassan ZM TI - Alterations in the Serum Levels of Chemokines 20 Years After Sulfur Mustard Exposure: Sardasht-Iran Cohort Study JO - International Immunopharmacology VL - 9 IS - 13-14 SP - 1471 EP - 1476 PY - 2009 ER -

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