Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations

Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics) Publisher Pubmed

Ghazanfari T¹ ; Kariminia A² ; Yaraee R¹ ; Faghihzadeh S³ ; Ardestani SK⁴ ; Ebtekar M⁵ ; Mostafaie A⁶ ; Foroutan A⁷ ; Rezaei A⁸ ; Shams J¹ ; Mahmoudi M⁹ ; Vaezmahdavi MR¹⁰ ; Soroush MR¹¹ ; Jalalinadoushan M¹ Show All Authors

Ghazanfari T¹
Kariminia A²
Yaraee R¹
Faghihzadeh S³
Ardestani SK⁴
Ebtekar M⁵
Mostafaie A⁶
Foroutan A⁷
Rezaei A⁸
Shams J¹
Mahmoudi M⁹
Vaezmahdavi MR¹⁰
Soroush MR¹¹
Jalalinadoushan M¹
Moaiedmohseni S¹
Ajdary S¹²
Darabi H¹²
Naghizadeh MM¹³
Kazemi H^{14, 15}
Hassan ZM⁵

Show Affiliations

1. Dep of Immunology, Shahed University, Immunoregulation Research Center, Tehran, PO. Box: 14155-7435, Iran
2. Department of Pediatrics, University of British Columbia, Vancouver, Canada
3. Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
5. Department of Immunology, Tarbiat Modares University, Tehran, Iran
6. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
7. Department of Physiology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
8. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
9. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
10. Department of Physiology, Shahed University, Tehran, Iran
11. Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
12. Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
13. Fasa University of Medical Science, Fars Province, Iran
14. Shafa Neuroscience Research Center, Tehran, Iran
15. Department of Pediatrics, Shahed University, Tehran, Iran

Source: International Immunopharmacology Published:2013

Abstract

The most important long-term morbidity problem of sulfur mustard (SM) toxicity is pulmonary complications but the pathogenesis of these complications is not clearly understood. This study evaluates the peripheral blood mononuclear sub-sets and their correlation with pulmonary function in SM exposed civilian cases 20 years post-exposure as gathered in the context of the Sardasht-Iran Cohort Study (SICS). Samples were randomly selected from two groups, SM-exposed (n = 372) and control (n = 128), with the same ethnicity, culture, and demography. Three color flow cytometry was applied for peripheral blood mononuclear sub-population determination. Results indicated a significant decrease in CD45 +/CD3 +, CD45 +/CD3 +/CD4 +, and an increase in CD3 +/CD16+56 + percentages. It was also found that absolute count of NK cells was highly increased in peripheral blood of exposed cases. There was a significant increase in NK cell count of SM exposed group with pulmonary problems as compared to the same group without pulmonary problems (p-value < 0.04) based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD). The findings showed a significant negative correlation between absolute numbers of T lymphocyte and FVC % and positive correlation with FEV1/FVC%. The results also demonstrated that absolute numbers of monocytes had a negative correlation with FVC %. We propose that NK and T cells are probably involved in the pathogenesis or immune reactions to the delayed pulmonary complications induced by SM. This hypothesis should be tested in a more severe pulmonary complicated group. © 2013 Elsevier B.V.

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Style	Citing Format
MLA	Ghazanfari T, et al.. "Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics)." International Immunopharmacology, vol. 17, no. 3, 2013, pp. 931-935.
APA	Ghazanfari T, Kariminia A, Yaraee R, Faghihzadeh S, Ardestani SK, Ebtekar M, Mostafaie A, Foroutan A, Rezaei A, Shams J, Mahmoudi M, Vaezmahdavi MR, Soroush MR, Jalalinadoushan M, Moaiedmohseni S, Ajdary S, Darabi H, Naghizadeh MM, Kazemi H, Hassan ZM (2013). Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics). International Immunopharmacology, 17(3), 931-935.
Chicago	Ghazanfari T, Kariminia A, Yaraee R, Faghihzadeh S, Ardestani SK, Ebtekar M, Mostafaie A, et al.. "Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics)." International Immunopharmacology 17, no. 3 (2013): 931-935.
Harvard	Ghazanfari T et al. (2013) 'Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics)', International Immunopharmacology, 17(3), pp. 931-935.
Vancouver	Ghazanfari T, Kariminia A, Yaraee R, Faghihzadeh S, Ardestani SK, Ebtekar M, et al.. Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics). International Immunopharmacology. 2013;17(3):931-935.
BibTex	@article{ author = {Ghazanfari T and Kariminia A and Yaraee R and Faghihzadeh S and Ardestani SK and Ebtekar M and Mostafaie A and Foroutan A and Rezaei A and Shams J and Mahmoudi M and Vaezmahdavi MR and Soroush MR and Jalalinadoushan M and Moaiedmohseni S and Ajdary S and Darabi H and Naghizadeh MM and Kazemi H and Hassan ZM}, title = {Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics)}, journal = {International Immunopharmacology}, volume = {17}, number = {3}, pages = {931-935}, year = {2013} }
RIS	TY - JOUR AU - Ghazanfari T AU - Kariminia A AU - Yaraee R AU - Faghihzadeh S AU - Ardestani SK AU - Ebtekar M AU - Mostafaie A AU - Foroutan A AU - Rezaei A AU - Shams J AU - Mahmoudi M AU - Vaezmahdavi MR AU - Soroush MR AU - Jalalinadoushan M AU - Moaiedmohseni S AU - Ajdary S AU - Darabi H AU - Naghizadeh MM AU - Kazemi H AU - Hassan ZM TI - Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics) JO - International Immunopharmacology VL - 17 IS - 3 SP - 931 EP - 935 PY - 2013 ER -

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