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Long Term Impact of Sulfur Mustard Exposure on Peripheral Blood Mononuclear Subpopulations - Sardasht-Iran Cohort Study (Sics) Publisher Pubmed



Ghazanfari T1 ; Kariminia A2 ; Yaraee R1 ; Faghihzadeh S3 ; Ardestani SK4 ; Ebtekar M5 ; Mostafaie A6 ; Foroutan A7 ; Rezaei A8 ; Shams J1 ; Mahmoudi M9 ; Vaezmahdavi MR10 ; Soroush MR11 ; Jalalinadoushan M1 Show All Authors
Authors
  1. Ghazanfari T1
  2. Kariminia A2
  3. Yaraee R1
  4. Faghihzadeh S3
  5. Ardestani SK4
  6. Ebtekar M5
  7. Mostafaie A6
  8. Foroutan A7
  9. Rezaei A8
  10. Shams J1
  11. Mahmoudi M9
  12. Vaezmahdavi MR10
  13. Soroush MR11
  14. Jalalinadoushan M1
  15. Moaiedmohseni S1
  16. Ajdary S12
  17. Darabi H12
  18. Naghizadeh MM13
  19. Kazemi H14, 15
  20. Hassan ZM5

Source: International Immunopharmacology Published:2013


Abstract

The most important long-term morbidity problem of sulfur mustard (SM) toxicity is pulmonary complications but the pathogenesis of these complications is not clearly understood. This study evaluates the peripheral blood mononuclear sub-sets and their correlation with pulmonary function in SM exposed civilian cases 20 years post-exposure as gathered in the context of the Sardasht-Iran Cohort Study (SICS). Samples were randomly selected from two groups, SM-exposed (n = 372) and control (n = 128), with the same ethnicity, culture, and demography. Three color flow cytometry was applied for peripheral blood mononuclear sub-population determination. Results indicated a significant decrease in CD45 +/CD3 +, CD45 +/CD3 +/CD4 +, and an increase in CD3 +/CD16+56 + percentages. It was also found that absolute count of NK cells was highly increased in peripheral blood of exposed cases. There was a significant increase in NK cell count of SM exposed group with pulmonary problems as compared to the same group without pulmonary problems (p-value < 0.04) based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD). The findings showed a significant negative correlation between absolute numbers of T lymphocyte and FVC % and positive correlation with FEV1/FVC%. The results also demonstrated that absolute numbers of monocytes had a negative correlation with FVC %. We propose that NK and T cells are probably involved in the pathogenesis or immune reactions to the delayed pulmonary complications induced by SM. This hypothesis should be tested in a more severe pulmonary complicated group. © 2013 Elsevier B.V.
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