Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Global, Regional, and National Burden of Hepatitis B, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Sheena BS1 ; Hiebert L5, 6 ; Han H1 ; Ippolito H2 ; Abbasikangevari M7 ; Abbasikangevari Z7, 15 ; Abbastabar H16 ; Abdoli A29 ; Abubaker Ali H30 ; Adane MM32 ; Adegboye OA35 ; Adnani QES36 ; Advani SM37, 38 ; Afzal MS39 Show All Authors
Authors
  1. Sheena BS1
  2. Hiebert L5, 6
  3. Han H1
  4. Ippolito H2
  5. Abbasikangevari M7
  6. Abbasikangevari Z7, 15
  7. Abbastabar H16
  8. Abdoli A29
  9. Abubaker Ali H30
  10. Adane MM32
  11. Adegboye OA35
  12. Adnani QES36
  13. Advani SM37, 38
  14. Afzal MS39
  15. Afzal S40, 41
  16. Aghaie Meybodi M42
  17. Ahadinezhad B44
  18. Ahinkorah BO48
  19. Ahmad S49
  20. Ahmad T50
  21. Ahmadi S8
  22. Ahmed H51
  23. Ahmed MB52, 53
  24. Rashid TA54
  25. Akalu GT55, 57
  26. Aklilu A58
  27. Akram T62
  28. Al Hamad H63, 64
  29. Alahdab F65
  30. Alem A66
  31. Alem DT73
  32. Alhalaiqa FAN74, 75
  33. Alhassan RK76
  34. Ali L78
  35. Ali MA79
  36. Alimohamadi Y17, 80
  37. Alipour V81, 82
  38. Alkhayyat M93
  39. Almustanyir S96, 97
  40. Alraddadi RM98
  41. Altawalah H101, 102
  42. Amini S103
  43. Amu H77
  44. Ancuceanu R104
  45. Andrei CL105
  46. Andrei T109
  47. Anoushiravani A18
  48. Ansar A110, 111
  49. Anyasodor AE112
  50. Arabloo J81
  51. Arabzozani M113
  52. Argaw AM114
  53. Argaw ZG59
  54. Arshad M117
  55. Artamonov AA118
  56. Ashraf T119
  57. Atlaw D115
  58. Ausloos F121
  59. Ausloos M109, 122
  60. Azadnajafabad S15
  61. Azangoukhyavy M7, 19
  62. Azari Jafari A123
  63. Azarian G124
  64. Bagheri S20
  65. Bahadory S127, 129
  66. Baig AA130
  67. Banach M131, 132
  68. Barati N133
  69. Barrow A134, 135
  70. Batiha AMM74
  71. Bejarano Ramirez DF136, 137
  72. Belgaumi UI138
  73. Berhie AY33
  74. Bhagat DS139
  75. Bhardwaj N140
  76. Bhardwaj P141, 142
  77. Bhattacharyya K145, 146
  78. Bhojaraja VS147
  79. Bijani A149
  80. Biondi A151
  81. Bodicha BBA60
  82. Bojia HA153
  83. Boloor A157
  84. Bosetti C160
  85. Braithwaite D162, 163
  86. Briko NI164
  87. Butt ZA165, 166
  88. Camera LA167, 168
  89. Chakinala RC169
  90. Chakraborty PA170
  91. Charan J143
  92. Chen S171
  93. Choi JYJ172
  94. Choudhari SG173
  95. Chowdhury FR176
  96. Chu DT177
  97. Chung SC178, 179
  98. Cortesi PA180
  99. Cowie BC181, 183
  100. Culbreth GT1
  101. Dadras O184
  102. Dai X1, 3
  103. Dandona L1, 185, 186
  104. Dandona R1, 3, 185
  105. De La Hoz FP187
  106. Debela SA188
  107. Dedefo MG189
  108. Demeke FM34
  109. Demie TGG56, 190
  110. Demissie GD67
  111. Derbew Molla M68
  112. Desta AA69
  113. Dhamnetiya D191
  114. Dhimal ML192, 193
  115. Dhimal M194
  116. Didehdar M196
  117. Doan LP199, 200
  118. Dorostkar F83
  119. Drake TM202
  120. Eghbalian F125
  121. Ekholuenetale M203, 204
  122. El Sayed I207
  123. El Sayed Zaki M208
  124. Elhadi M209
  125. Elmonem MA210
  126. Elsharkawy A211
  127. Enany S213
  128. Enyew DB154
  129. Erkhembayar R214
  130. Eskandarieh S21
  131. Esmaeilzadeh F215
  132. Ezzikouri S216
  133. Farrokhpour H22, 217
  134. Fetensa G220
  135. Fischer F221
  136. Foroutan M222, 223
  137. Gad MM94, 224
  138. Gaidhane AM173
  139. Gaidhane S174
  140. Galles NC1
  141. Gallus S161
  142. Gebremeskel TG225
  143. Gebreyohannes EA70, 226
  144. Ghadiri K227, 228
  145. Ghaffari K230
  146. Ghafourifard M231
  147. Ghamari SH7, 15
  148. Ghashghaee A45
  149. Gholami A237, 238
  150. Gholizadeh A239
  151. Gilani A240, 241
  152. Goel A242
  153. Golechha M243
  154. Goleij P244
  155. Golinelli D245
  156. Gorini G246
  157. Goshu YA247
  158. Griswold MG1
  159. Gubari MIM248
  160. Gupta B249
  161. Gupta S250
  162. Gupta VB251
  163. Gupta VK252
  164. Haddadi R126
  165. Halwani R253, 254
  166. Hamid SS257
  167. Hamidi S258
  168. Hanif A120
  169. Haque S259
  170. Harapan H260
  171. Hargono A261
  172. Hariri S18, 262
  173. Hasaballah AI263
  174. Hasan SMM264
  175. Hassanipour S265, 266
  176. Hassankhani H232
  177. Hay SI1, 3
  178. Hayat K267, 268
  179. Heidari G269
  180. Herteliu C109, 270
  181. Heyi DZ116
  182. Hezam K271, 272
  183. Holla R273
  184. Hosseini MS17
  185. Hosseini M23, 233
  186. Hosseinzadeh M30, 201
  187. Hostiuc M106
  188. Househ M276
  189. Huang J277
  190. Hussein NR278
  191. Iavicoli I279
  192. Ibitoye SE205
  193. Ilesanmi OS206, 280
  194. Ilic IM281
  195. Ilic MD283
  196. Irham LM284, 285
  197. Islam JY286
  198. Ismail NE287
  199. Jacobsen KH288
  200. Jadidiniaragh F234
  201. Javadi Mamaghani A9, 235
  202. Jayaram S289
  203. Jayawardena R290, 292
  204. Jebai R294
  205. Jha RP191, 295
  206. Joseph N158
  207. Joukar F265, 266
  208. Kaambwa B296, 297
  209. Kabir A84
  210. Kabir Z298
  211. Kalhor R43, 46
  212. Kandel H299, 300
  213. Kanko TKT60
  214. Kantar RS301, 302
  215. Karaye IM303
  216. Kassa BG247
  217. Kemp Bohan PM304
  218. Keykhaei M15, 24
  219. Khader YS305
  220. Khajuria H306
  221. Khan G307
  222. Khan IA308
  223. Khan J309
  224. Khan MA310, 311
  225. Khanali J7, 15
  226. Khater AM212
  227. Khatib MN175
  228. Khodadost M312, 313
  229. Khoja AT314
  230. Khosravizadeh O47, 315
  231. Khubchandani J316
  232. Kim GR317
  233. Kim H321
  234. Kim MS322, 323
  235. Kim YJ324
  236. Kocarnik JM1
  237. Kolahi AA7, 10
  238. Koteeswaran R325
  239. Kumar GA185
  240. La Vecchia C326
  241. Lal DK185
  242. Landires I327, 330
  243. Lasrado S331
  244. Lazarus JV332
  245. Ledda C152
  246. Lee DW318, 319
  247. Lee SW333
  248. Lee YY334, 335
  249. Levi M336, 337
  250. Li J338
  251. Lim SS1, 3
  252. Lobo SW339, 341
  253. Lopukhov PD164
  254. Loureiro JA342, 343
  255. Maclachlan JH182
  256. Magdy Abd El Razek H344
  257. Magdy Abd El Razek M345
  258. Majeed A346
  259. Makki A255
  260. Malekpour MR15
  261. Malekzadeh R18, 348
  262. Malik AA99, 120
  263. Mansourghanaei F265, 266
  264. Mansournia MA17
  265. Martinsmelo FR350
  266. Matthews PC351, 352
  267. Mendoza W353
  268. Menezes RG354
  269. Meretoja TJ355, 356
  270. Mersha AG71, 357
  271. Mestrovic T359, 360
  272. Miller TR361, 362
  273. Minh LHN363
  274. Mirica A109
  275. Mirmoeeni S123
  276. Mirrakhimov EM364, 365
  277. Misra S144
  278. Mithra P158
  279. Moazen B366, 367
  280. Mohamadkhani A18
  281. Mohammadi M368
  282. Mohammed S369, 370
  283. Moka N371, 372
  284. Mokdad AH1, 3
  285. Moludi J229, 236
  286. Momtazmanesh S15, 22
  287. Monasta L373
  288. Moradi G374, 375
  289. Moradzadeh M376
  290. Moradzadeh R197
  291. Moraga P377
  292. Mostafavi E378, 379
  293. Mubarik S380
  294. Muniyandi M381
  295. Murray CJL1, 3
  296. Naghavi M1, 3
  297. Naimzada MD382, 383
  298. Narasimha Swamy S384
  299. Natto ZS100, 385
  300. Nayak BP307
  301. Nazari J198
  302. Negoi I107, 386
  303. Negru SM387
  304. Nejadghaderi SA11, 218
  305. Neupane Kandel S388
  306. Nguyen HLT389
  307. Ngwa CH390
  308. Niazi RK391
  309. Nnaji CA392, 393
  310. Noubiap JJ394
  311. Nowroozi A22
  312. Nunezsamudio V328, 329
  313. Oancea B395
  314. Ochir C214, 396
  315. Odukoya OO397, 398
  316. Oh IH399
  317. Olagunju AT400, 401
  318. Olakunde BO402
  319. Omar Bali A31
  320. Omer E403
  321. Otstavnov SS382, 404
  322. Oumer B405
  323. Padubidri JR274
  324. Pana A109, 406
  325. Pandey A185
  326. Park EC317, 318
  327. Pashazadeh Kan F92
  328. Patel UK407
  329. Paudel U195, 408
  330. Petcu IR109
  331. Piracha ZZ409
  332. Pollok RCG410
  333. Postma MJ411, 412
  334. Pourshams A18
  335. Poustchi H18
  336. Rabiee M413
  337. Rabiee N414
  338. Rafiei A415, 416
  339. Rafiei S47
  340. Raghuram PM157
  341. Rahman M417
  342. Rahmani AM418
  343. Rahmawaty S419
  344. Rajesh A420
  345. Ranasinghe P291
  346. Rao CR275
  347. Rao SJ421
  348. Rashidi M7, 422
  349. Rashidi MM15
  350. Rawaf DL347, 423
  351. Rawaf S346, 424
  352. Rawassizadeh R425
  353. Rezaei N15, 25
  354. Rezapour A81
  355. Rezazadehkhadem S15
  356. Rodriguez JAB426
  357. Rwegerera GM427
  358. Sabour S12
  359. Saddik B256
  360. Saeb MR428
  361. Saeed U429, 430
  362. Sahebkar A431, 432
  363. Saifurrahman KM433, 434
  364. Salahi S84, 435
  365. Salimzadeh H18
  366. Sampath C340
  367. Samy AM436
  368. Sanabria J437, 438
  369. Sanmarchi F245
  370. Santricmilicevic MM281, 282
  371. Sarveazad A85
  372. Sathian B62, 440
  373. Sawhney M441
  374. Seidu AA442, 443
  375. Sepanlou SG18, 348
  376. Seylani A444
  377. Shahabi S349
  378. Shaikh MA445
  379. Shaker E26, 218
  380. Shakhmardanov MZ446
  381. Shannawaz M448
  382. Shenoy SM273
  383. Shetty JK148
  384. Shetty PH159
  385. Shibuya K449
  386. Shin JI320
  387. Shobeiri P26, 219
  388. Sibhat MM450
  389. Singh AD95
  390. Singh JA451, 452
  391. Singh S143
  392. Skryabin VY453
  393. Skryabina AA447
  394. Sohrabpour AA27
  395. Song S454
  396. Tabaeian SP86
  397. Tadesse EG60
  398. Taheri M13, 87
  399. Tampa M108, 455
  400. Tan KK456
  401. Tavakoli A88, 89
  402. Tbakhi A457
  403. Tefera BN155
  404. Tehranibanihashemi A90, 91
  405. Tesfaw HM458
  406. Thapar R158
  407. Thavamani A439, 459
  408. Tohidast SA460
  409. Tollosa DN358
  410. Tosti ME461
  411. Tovanipalone MR462, 463
  412. Traini E373, 464
  413. Tran MTN293, 465
  414. Trihandini I466
  415. Tusa BS467
  416. Ullah I468, 469
  417. Vacante M151
  418. Valadan Tahbaz S470, 471
  419. Valdez PR168, 473
  420. Varthya SB143
  421. Vo B474
  422. Waheed Y475
  423. Weldesenbet AB156
  424. Woldemariam M61
  425. Xu S476, 477
  426. Yahyazadeh Jabbari SH470
  427. Yaseri M14, 17
  428. Yeshaw Y66
  429. Yigit V478
  430. Yirdaw BW72
  431. Yonemoto N479, 480
  432. Yu C380
  433. Yunusa I481
  434. Zahir M28, 472
  435. Zaki L128
  436. Zamani M150
  437. Zamanian M197
  438. Zastrozhin MS482, 483
  439. Vos T1, 3
  440. Ward JW5, 484
  441. Dirac MA1, 3, 4

Source: The Lancet Gastroenterology and Hepatology Published:2022


Abstract

Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation: The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Other Related Docs