Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cardiovascular Risk Factors in Children and Adolescents With Congenital Adrenal Hyperplasia Publisher



Dehkordi EH1 ; Khaheshi S2 ; Mostofizadeh N1 ; Hashemipour M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics Endocrinology, Faculty of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Advanced Biomedical Research Published:2021


Abstract

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by impaired steroidogenesis. Glucocorticoid treatment with increased androgens may lead to cardiovascular and metabolic effects in these patients. In this study, we investigated the relationship between cardiovascular risk factors and androgen levels in children and adolescents with CAH due to 21 hydroxylase deficiency. Materials and Methods: A cross-sectional study of 78 patients (37 boys and 41 girls) with CAH aged 3–17 years. Anthropometric, body mass index (BMI), systolic (SBP), and diastolic (DBP) blood pressure were measured. Fasting blood glucose with plasma insulin and lipids were measured, and insulin resistance (HOMA-IR) calculated using the homeostasis assessment model. Furthermore, testosterone, Dehydroepiandrosterone sulfate (DHEAS), and 17-Hydroxyprogesterone (17OHP) were investigated. Results: The mean SBP and DBP were 112.01 ± 19.13 and 69.77 ± 7.56, respectively. The mean of HOMA-IR in patients was 2.25 ± 1.46. The frequency of patients with overweight and High HOMA index were, respectively, 33.3% and 29.3%. The correlation analysis between clinical characteristics and androgen serum levels showed that DBP and BMI had a significant positive correlation with 17OHP. The median regression analysis showed, only DBP in the adjusted model had a significant positive effect with 17OHP level (P < 0.05), and no significant relationship was observed for other characteristics. Conclusion: A significant association was found between BMI and DBP with serum concentrations of 17-OHP, suggesting that elevated 17-OHP can lead to an increased risk of cardiovascular disorders in children and adolescents with CAH. © 2021 Advanced Biomedical Research.
Related Docs
View other Related Docs
1. The Spectrum of Clinical, Hormonal Findings in Children With Congenital Adrenal Hyperplasia in Isfahan Province; a 20-Year Review, Hormone Molecular Biology and Clinical Investigation (2024)
2. Demographic Characteristics and Clinical Findings in Patients With Congenital Adrenal Hyperplasia in Isfahan City, Iran, Journal of Isfahan Medical School (2018)
3. A Case of Congenital Lipoid Adrenal Hyperplasia, International Journal of Preventive Medicine (2012)
4. Association Between Serum Calcium and Metabolic Syndrome Indicators Among Women in Mazandaran, Northern Province of Iran, Malaysian Journal of Nutrition (2016)
5. Association of Anthropometric Measures With Cardiovascular Risk Factors and Metabolic Syndrome in Normal-Weight Children and Adolescents: The Caspian Iii Study, Obesity Facts (2013)
6. Hypertension and Cardiovascular Manifestations in Children and Adolescents With Secreting Adrenal Tumors, Iranian Journal of Endocrinology and Metabolism (2011)
7. Obesity and Metabolic Syndrome Among a Representative Sample of Iranian Adolescents, Southeast Asian Journal of Tropical Medicine and Public Health (2012)
8. Age-, Sex-, and Puberty-Associated Reference Intervals for Lipid Profile in Iranian Children and Adolescents, International Journal of Endocrinology (2023)
Experts (# of related papers)
View all Related Experts
Mahin Hashemipour (7)
Roya Kelishadi (5)
Other Related Docs
9. Androgen Receptor-Reduced Sensitivity Is Associated With Increased Mortality and Poorer Glycaemia in Men With Type 2 Diabetes Mellitus: A Prospective Cohort Study, Cardiovascular Endocrinology and Metabolism (2020)
10. New Molecular Insights Into the A218v Variant Impact on the Steroidogenic Acute Regulatory Protein (Star) Associated With 46, Xy Disorders of Sexual Development, Molecular Genetics and Genomics (2023)
11. Metabolic Syndrome in Iranian Youths: A Population-Based Study on Junior and High Schools Students in Rural and Urban Areas, Journal of Diabetes Research (2013)
12. The Relative Prevalence of Testicular Adrenal Rest Tumors in Fewer Than 20-Years-Old Boys With Congenital Adrenal Hyperplasia, Journal of Isfahan Medical School (2014)
13. The Effect of N-3 Polyunsaturated Fatty Acid Supplementation on Androgen Status in Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials, Hormone and Metabolic Research (2016)
14. Association of Hypertriglyceridemic-Waist Phenotype With Liver Enzymes and Cardiometabolic Risk Factors in Adolescents: The Caspian-Iii Study; [Associacao Do Fenotipo De Cintura Hipertrigliceridemica Com Enzimas Hepaticas E Fatores De Risco Cardiometabolico Em Adolescentes: O Estudo Caspian-Iii], Jornal de Pediatria (2016)
15. Reference Range of Testosterone and Dehydroepiandrosterone Sulfate Levels in Women During Reproductive Age in the Iranian Population, Journal of Research in Medical Sciences (2023)
16. Multiparity and Risk of Metabolic Syndrome: Isfahan Healthy Heart Program, Metabolic Syndrome and Related Disorders (2009)
17. Prevalence of Nephrocalcinosis in Children With Congenital Adrenal Hyperplasia, Journal of Research in Medical Sciences (2022)
18. Association Between Mediterranean Diet and Metabolic Health Status Among Adults Was Not Mediated Through Serum Adropin Levels, BMC Public Health (2025)
19. The Prevalence of Hypogonadism in Diabetic Men in Isfahan Endocrine and Metabolism Research Center, Isfahan, Iran, Journal of Research in Medical Sciences (2012)
20. A Rare Enzymatic Defect, True Isolated 17,20-Lyase Deficiency Leading to Endocrine Disorders and Infertility: Case Report, Gynecological Endocrinology (2020)
21. Paediatric Metabolic Syndrome and Associated Anthropometric Indices: The Caspian Study, Acta Paediatrica, International Journal of Paediatrics (2006)
22. Serum 25-Hydroxyvitamin D Is Associated With Prediabetes, Type 2 Diabetes Mellitus, and Insulin Resistance in Children: A Systematic Review and Dose-Response Meta-Analysis of Epidemiologic Studies, Nutrition Reviews (2025)
23. A Three-Country Study on the Components of the Metabolic Syndrome in Youths: The Big Study, International Journal of Pediatric Obesity (2010)
24. Effect of Androgen Deprivation Therapy on Cardiovascular Risk Factors in Prostate Cancer, Journal of Research in Medical Sciences (2013)
25. Lipid and Glucose Serum Levels in Children With Congenital Heart Disease, Journal of Tehran University Heart Center (2014)