Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on Tlr4, Nf-Κb and Irf3 Expression in Young Overweight and Obese Girls Publisher Pubmed



Soltani N1 ; Esmaeil N2, 3 ; Marandi SM1 ; Hovsepian V1 ; Momen T4 ; Shahsanai A5 ; Kelishadi R6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran
  3. 3. Research Institute for Primordial Prevention of Noncommunicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Community and Family Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Public Health Genomics Published:2020


Abstract

Obesity is commonly associated with immunometabolic dysfunctions. Activation of inflammatory macrophages through TLR4 (toll-like receptor 4) and the anti-inflammatory impact of exercise have been and are the new concerns among researchers. A new short-term combined high-intensity interval training was proposed in young sedentary overweight/obese females. All participants were allocated to one of two groups: the exercise group (EG) and the control group (CG), where the EG participated in a 2-week combined training and the CG continued its routine lifestyle. Gene expression levels of TLR4, NF-κB(nuclear factor κB), and IRF3 (interferon regulatory factor 3) were assessed by real-time PCR. Physiological, anthropometric, and biomedical metabolic factors were assessed. The between-group comparisons indicated a tendency to a decrease in NF-κB gene expression in the EG. The IRF3 levels were not significantly changed compared to CG and the levels before training. Fasting glucose levels and β-cell function revealed a significant improvement in EG. These findings indicated that this protocol decreased meta-inflammation levels and improved insulin resistance independent of body composition changes. Consequently, combined training may be recommended as a therapeutic approach in metabolic diseases. © 2020 S. Karger AG, Basel. Copyright: All rights reserved.
Related Docs
View other Related Docs
1. Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses Through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females, Obesity Facts (2020)
2. The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions, Diabetes, Metabolic Syndrome and Obesity (2020)
3. A 2-Week Combined High-Intensity Interval Training Regulates Inflammatory Status in Young Females With Obesity; [Un Intervalle Training Combine a Haute Intensite De 2 Semaines Regule L’Etat Inflammatoire De Jeunes Femmes Obeses], Science and Sports (2023)
4. Resistance Exercise Training Augments the Immunomodulatory Adaptations to Aerobic High-Intensity Interval Training, European Journal of Sport Science (2023)
5. Meta-Inflammatory State and Insulin Resistance Can Improve After 10 Weeks of Combined All-Extremity High-Intensity Interval Training in Sedentary Overweight/Obese Females: A Quasi-Experimental Study, Journal of Diabetes and Metabolic Disorders (2020)
6. Inflammatory Biomarkers’ Response to Two Different Intensities of a Single Bout Exercise Among Soccer Players, Iranian Red Crescent Medical Journal (2016)
7. Effect of Eicosapentaenoic Acid (Epa) and Vitamin E on the Blood Levels of Inflammatory Markers, Antioxidant Enzymes, and Lipid Peroxidation in Iranian Basketball Players, Iranian Journal of Public Health (2010)
8. The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women, Asian Journal of Sports Medicine (2019)
Experts (# of related papers)
View all Related Experts
Nafiseh Esmaeil (6)
Roya Kelishadi (5)
Other Related Docs
9. A Randomized Triple-Masked Controlled Trial on the Effects of Synbiotics on Inflammation Markers in Overweight Children, Jornal de Pediatria (2014)
10. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
11. Effect of Combination Exercise Training on Metabolic Syndrome Parameters in Postmenopausal Women With Breast Cancer, Journal of Cancer Research and Therapeutics (2012)
12. The Effect of Quercetin Supplementation on Selected Markers of Inflammation and Oxidative Stress, Journal of Research in Medical Sciences (2012)
13. Association Between the Dietary Inflammatory Index and Obesity in Otherwise Healthy Adults: Role of Age and Sex, International Journal of Clinical Practice (2021)
14. Comparing Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Patients With and Without Metabolic Syndrome, Journal of Isfahan Medical School (2015)
15. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
16. Effect of Fermented Camel Milk on Glucose Metabolism, Insulin Resistance, and Inflammatory Biomarkers of Adolescents With Metabolic Syndrome: A Double-Blind, Randomized, Crossover Trial, Journal of Research in Medical Sciences (2018)
17. The Effect of Food Ration Bar Enriched With Β-Alanine, L-Arginine, and Nigella Sativa on Performance and Inflammation Following Intense Military Training: A Double-Blind Randomized Clinical Trial, Food Science and Nutrition (2021)
18. Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Interferon and Cytokine Research (2020)
19. Effects of 12 Weeks Aerobic Training on Body Composition, Serum Homocysteine and Crp Levels in Obese Women, Journal of Isfahan Medical School (2011)
20. The Effect of Educational and Encouragement Interventions on Anthropometric Characteristics, Obestatin and Adiponectin Levels, ARYA Atherosclerosis (2019)
21. The Effect of All Extremity High Intensity Interval Training on Athero-Protective Factors and Endothelial Function in Overweight and Obese Women, International Journal of Preventive Medicine (2021)
22. The Alternate-Day Fasting Diet Is a More Effective Approach Than a Calorie Restriction Diet on Weight Loss and Hs-Crp Levels, International Journal for Vitamin and Nutrition Research (2021)
23. Association of Serum Ceruloplasmin Level With Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran, Journal of Obesity (2012)
24. Association Between Dietary Inflammatory Index and Phase Angle in University Employees: A Cross-Sectional Study, Scientific Reports (2024)
25. The Effect of Aerobic Training on Tumor Growth and Expression of Bcl-2 Gene and Protein in Female Mice With Breast Cancer, Iranian Journal of Breast Diseases (2021)
26. Cholesterol to Saturated Fat Index (Csi), Metabolic Parameters and Inflammatory Factors Among Obese Individuals, BMC Endocrine Disorders (2024)
27. Association of Childhood Obesity and the Immune System: A Systematic Review of Reviews, Childhood Obesity (2017)
28. Evaluation of Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Individuals With and Without Metabolic Syndrome in Isfahan, Iran, ARYA Atherosclerosis (2012)
29. Does Exercise Training Attenuate Cisplatin Nephrotoxicity?, Journal of Renal Injury Prevention (2020)
30. Differences in the Impact of Various Types of Exercise on Irisin Levels: A Systematic Review and Meta‑Analysis, International Journal of Preventive Medicine (2024)
31. Probiotic Consumption and Inflammatory Markers in Athletes: A Systematic Review and Meta-Analysis, International Journal of Food Properties (2020)
32. Irisin, a Mediator of Muscle Crosstalk With Other Organs: From Metabolism Regulation to Protective and Regenerative Effects, Current Protein and Peptide Science (2022)
33. Is the Neutrophil-To-Lymphocyte Ratio an Exceptional Indicator for Metabolic Syndrome Disease and Outcomes?, Endocrine Practice (2022)
34. The Association Between Dietary Inflammatory Index With Some Cardio-Metabolic Risk Indices Among the Patients With Type 2 Diabetes From Hoveyzeh Cohort Study: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
35. Effects of Two Different School-Based Training on Serum Mir15b Expression and Lipid Profile of Adolescents With Obesity, International Journal of Preventive Medicine (2022)
36. Modulatory Effects of Thymol and Carvacrol on Inflammatory Transcription Factors in Lipopolysaccharide-Treated Macrophages, Journal of Immunotoxicology (2016)
37. Relationship Between Angptl3 and Vo2max, Body Composition and Markers of Metabolic Syndrome and Effect of Interval Training on These Variables in Overweight and Obese Women, Journal of Mazandaran University of Medical Sciences (2021)
38. Comparative Effects of Carbohydrate Versus Fat Restriction on Serum Levels of Adipocytokines, Markers of Inflammation, and Endothelial Function Among Women With the Metabolic Syndrome: A Randomized Cross-Over Clinical Trial, Annals of Nutrition and Metabolism (2013)
39. The Effect of 8 Week of Aerobic Exercise on Heart Cells Specific Biochemical Indicators in Women With Type 2 Diabetes Mellitus: A Randomized Clinical Trial, Journal of Isfahan Medical School (2021)
40. Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice, Mediators of Inflammation (2010)
41. The Effects of Aerobic Training, Resistance Training, Combined Training, and Healthy Eating Recommendations on Lipid Profile and Body Mass Index in Overweight and Obese Children and Adolescents: A Randomized Clinical Trial, ARYA Atherosclerosis (2020)
42. Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: A Systematic Review and Meta-Analysis, Obesity Surgery (2019)
43. Effect of Green Coffee Bean Extract Supplementation on Liver Function and Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Clinical Practice (2021)
44. The Effect of Moderate Substitution of Dietary Carbohydrates by Fats on Serum Levels of Adipocytokines, Inflammatory Indices, and Biomarkers of Endothelial Function Amongwomen With Metabolic Syndrome, Journal of Zanjan University of Medical Sciences and Health Services (2012)
45. Stress Biomarker Responses to Different Protocols of Forced Exercise in Chronically Stressed Rats, Journal of Bodywork and Movement Therapies (2017)