Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Meta-Inflammatory State and Insulin Resistance Can Improve After 10 Weeks of Combined All-Extremity High-Intensity Interval Training in Sedentary Overweight/Obese Females: A Quasi-Experimental Study Publisher



Soltani N1 ; Marandi SM1 ; Kazemi M2 ; Esmaeil N3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2020


Abstract

Objective: The effects of exercise training on suppression of inflammation have been proposed as a therapeutic approach in recent years to modify the obesity-induced inflammatory status and immunometabolic disorders. The present study aimed to assess the impacts of an all-extremity combined high-intensity interval training (HIIT) on inflammatory state and glycolipid metabolism in young sedentary overweight and obese females. Method: This was an quasi-experimental study which was applied by comparing two groups. The participants were allocated to two active (AG, n = 15) and inactive (IG, n = 15) groups. The serum level of adiponectin, interleukin (IL)-10, pentraxin 3 (PTX3), and tumor-necrosis factor α (TNFα) was measured in all subjects. Also, glycolipid metabolism was assessed by measuring the fasting lipid profile parameters, glucose, and insulin levels and calculating the homeostasis model assessment of insulin resistance (HOMA2-IR). Results: Following a 10-week combined all-extremity HIIT in the active subjects, the TNFα, PTX3/IL-10, and TNFα/adiponectin were significantly reduced. However, the absolute levels of adiponectin, IL-10, and PTX3 remained unchanged. Additionally, a significant decrease was found in insulin, LDL, and HOMA2-IR, while insulin sensitivity and HDL levels showed a significant increase in the active group compared to the inactive group. Conclusions: Our 10-week time-efficient combined all-extremity HIIT promoted an anti-inflammatory state and glycolipid metabolism improvement, suggesting this protocol as a practical therapeutic approach in sedentary obese females. © 2020, Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. A 2-Week Combined High-Intensity Interval Training Regulates Inflammatory Status in Young Females With Obesity; [Un Intervalle Training Combine a Haute Intensite De 2 Semaines Regule L’Etat Inflammatoire De Jeunes Femmes Obeses], Science and Sports (2023)
2. Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses Through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females, Obesity Facts (2020)
3. The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions, Diabetes, Metabolic Syndrome and Obesity (2020)
4. Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on Tlr4, Nf-Κb and Irf3 Expression in Young Overweight and Obese Girls, Public Health Genomics (2020)
5. The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women, Asian Journal of Sports Medicine (2019)
6. Resistance Exercise Training Augments the Immunomodulatory Adaptations to Aerobic High-Intensity Interval Training, European Journal of Sport Science (2023)
7. Inflammatory Biomarkers’ Response to Two Different Intensities of a Single Bout Exercise Among Soccer Players, Iranian Red Crescent Medical Journal (2016)
8. Effect of Low-Energy-Dense Diet Rich in Multiple Functional Foods on Weight-Loss Maintenance, Inflammation, and Cardiovascular Risk Factors: A Randomized Controlled Trial, Journal of the American College of Nutrition (2018)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (6)
Masoumeh Sadeghi (6)
Other Related Docs
9. Effects of Two Types of Moderate-And High-Intensity Interval Training on Serum Salusin-Α and Salusin-Β Levels and Lipid Profile in Women With Overweight/Obesity, Diabetes, Metabolic Syndrome and Obesity (2020)
10. The Effect of Omega-3 on the Serum Visfatin Concentration in Patients With Type Ii Diabetes, Journal of Research in Medical Sciences (2011)
11. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
12. Effect of Combination Exercise Training on Metabolic Syndrome Parameters in Postmenopausal Women With Breast Cancer, Journal of Cancer Research and Therapeutics (2012)
13. Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments, International Journal of Molecular Sciences (2020)
14. Effect of Non-Soy Legume Consumption on Inflammation and Serum Adiponectin Levels Among First-Degree Relatives of Patients With Diabetes: A Randomized, Crossover Study, Nutrition (2015)
15. The Effect of Quercetin Supplementation on Selected Markers of Inflammation and Oxidative Stress, Journal of Research in Medical Sciences (2012)
16. The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial, Hormone and Metabolic Research (2016)
17. Association Between the Dietary Inflammatory Index and Obesity in Otherwise Healthy Adults: Role of Age and Sex, International Journal of Clinical Practice (2021)
18. Comparing Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Patients With and Without Metabolic Syndrome, Journal of Isfahan Medical School (2015)
19. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
20. Effect of Fermented Camel Milk on Glucose Metabolism, Insulin Resistance, and Inflammatory Biomarkers of Adolescents With Metabolic Syndrome: A Double-Blind, Randomized, Crossover Trial, Journal of Research in Medical Sciences (2018)
21. The Effect of Food Ration Bar Enriched With Β-Alanine, L-Arginine, and Nigella Sativa on Performance and Inflammation Following Intense Military Training: A Double-Blind Randomized Clinical Trial, Food Science and Nutrition (2021)
22. Effect of Folic Acid and Metformin on Insulin Resistance and Inflammatory Factors of Obese Children and Adolescents, Journal of Research in Medical Sciences (2016)
23. Effect of Eicosapentaenoic Acid (Epa) and Vitamin E on the Blood Levels of Inflammatory Markers, Antioxidant Enzymes, and Lipid Peroxidation in Iranian Basketball Players, Iranian Journal of Public Health (2010)
24. Effects of 12 Weeks Aerobic Training on Body Composition, Serum Homocysteine and Crp Levels in Obese Women, Journal of Isfahan Medical School (2011)
25. The Effect of Educational and Encouragement Interventions on Anthropometric Characteristics, Obestatin and Adiponectin Levels, ARYA Atherosclerosis (2019)
26. The Effect of All Extremity High Intensity Interval Training on Athero-Protective Factors and Endothelial Function in Overweight and Obese Women, International Journal of Preventive Medicine (2021)
27. The Alternate-Day Fasting Diet Is a More Effective Approach Than a Calorie Restriction Diet on Weight Loss and Hs-Crp Levels, International Journal for Vitamin and Nutrition Research (2021)
28. Comparison of the Effects of 8-Weeks Aerobic Training and Resistance Training on Lipid Profile in Patients With Diabetes Type 2, Journal of Isfahan Medical School (2014)
29. The Beneficial Effects of Crocin Supplementation on Metabolic and Genetic Parameters in Type 2 Diabetic Patients Under Metformin Treatment: A Randomized Double-Blind Controlled Clinical Trial, Journal of Functional Foods (2024)
30. Association of Serum Ceruloplasmin Level With Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran, Journal of Obesity (2012)
31. Association Between Dietary Inflammatory Index and Phase Angle in University Employees: A Cross-Sectional Study, Scientific Reports (2024)
32. Cholesterol to Saturated Fat Index (Csi), Metabolic Parameters and Inflammatory Factors Among Obese Individuals, BMC Endocrine Disorders (2024)
33. Consumption of Energy-Dense Diets in Relation to Metabolic Syndrome and Inflammatory Markers in Iranian Female Nurses, Public Health Nutrition (2017)
34. Salsalate Improves Glycemic Control in Patients With Newly Diagnosed Type 2 Diabetes, Acta Diabetologica (2013)
35. Characterization of the Serum Levels of Meteorin-Like in Patients With Inflammatory Bowel Disease and Its Association With Inflammatory Cytokines, Lipids in Health and Disease (2020)
36. Obesity and Inflammation: Role of Adipokines, Journal of Isfahan Medical School (2016)
37. Evaluation of Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Individuals With and Without Metabolic Syndrome in Isfahan, Iran, ARYA Atherosclerosis (2012)
38. Does Exercise Training Attenuate Cisplatin Nephrotoxicity?, Journal of Renal Injury Prevention (2020)
39. Differences in the Impact of Various Types of Exercise on Irisin Levels: A Systematic Review and Meta‑Analysis, International Journal of Preventive Medicine (2024)
40. Changes in Liver Enzymes and Metabolic Profile in Adolescents With Fatty Liver Following Exercise Interventions, Pediatric Gastroenterology, Hepatology and Nutrition (2020)
41. Irisin, a Mediator of Muscle Crosstalk With Other Organs: From Metabolism Regulation to Protective and Regenerative Effects, Current Protein and Peptide Science (2022)
42. Is the Neutrophil-To-Lymphocyte Ratio an Exceptional Indicator for Metabolic Syndrome Disease and Outcomes?, Endocrine Practice (2022)
43. Effects of Dietary Patterns, Weight Loss Diets, and Dietary Components on Serum Adiponectin Levels, Journal of Isfahan Medical School (2012)
44. The Association Between Dietary Inflammatory Index With Some Cardio-Metabolic Risk Indices Among the Patients With Type 2 Diabetes From Hoveyzeh Cohort Study: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
45. The Effect of Sumac Supplementation on Insulin Resistance, Inflammation, Oxidative Stress, and Antioxidant Capacity in Adults With Metabolic Syndrome: A Randomized Crossover Clinical Trial, Phytotherapy Research (2023)
46. Alpha-Lipoic Acid Effect on Leptin and Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, European Journal of Clinical Pharmacology (2020)
47. Comparison of the Effect of Different Intensity Exercise on a Bicycle Ergometer on Postprandial Lipidemia in Type Ii Diabetic Patients, ARYA Atherosclerosis (2014)
48. Relationship Between Angptl3 and Vo2max, Body Composition and Markers of Metabolic Syndrome and Effect of Interval Training on These Variables in Overweight and Obese Women, Journal of Mazandaran University of Medical Sciences (2021)
49. Comparative Effects of Carbohydrate Versus Fat Restriction on Serum Levels of Adipocytokines, Markers of Inflammation, and Endothelial Function Among Women With the Metabolic Syndrome: A Randomized Cross-Over Clinical Trial, Annals of Nutrition and Metabolism (2013)
50. Effect of Flaxseed Oil on Glycemic Control and Inflammatory Markers in Overweight Adults With Pre-Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Journal of Herbal Medicine (2020)