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Protein-Polysaccharide Interactions for the Fabrication of Bioactive-Loaded Nanocarriers: Chemical Conjugates and Physical Complexes Publisher Pubmed



Falsafi SR1 ; Rostamabadi H2 ; Samborska K3 ; Mirarab S4 ; Rashidinejhad A5 ; Jafari SM1, 6
Authors
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Authors Affiliations
  1. 1. Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
  2. 2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Institute of Food Sciences, Warsaw University of Life Sciences WULS-SGGW, Warsaw, Poland
  4. 4. Sari Agricultural Sciences and Natural Resources University, Khazar Abad Road, P.O. Box 578, Sari, Iran
  5. 5. Riddet Institute, Massey University, Private Bag 11 222, Palmerston North, 4442, New Zealand
  6. 6. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Ourense, E-32004, Spain

Source: Pharmacological Research Published:2022


Abstract

As unique biopolymeric architectures, covalently and electrostatically protein-polysaccharide (PRO-POL) systems can be utilized for bioactive delivery by virtue of their featured structures and unique physicochemical attributes. PRO-POL systems (i. e, microscopic /nano-dimensional multipolymer particles, molecularly conjugated vehicles, hydrogels/nanogels/oleogels/emulgels, biofunctional films, multilayer emulsion-based delivery systems, particles for Pickering emulsions, and multilayer coated liposomal nanocarriers) possess a number of outstanding attributes, like biocompatibility, biodegradability, and bioavailability with low toxicity that qualify them as powerful agents for the delivery of different bioactive ingredients. To take benefits from these systems, an in-depth understanding of the chemical conjugates and physical complexes of the PRO-POL systems is crucial. In this review, we offer a comprehensive study concerning the unique properties of covalently/electrostatically PRO-POL systems and introduce emerging platforms to fabricate relevant nanocarriers for encapsulation of bioactive components along with a subsequent sustained/controlled release. © 2022 Elsevier Ltd
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