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Bixin-Loaded Colloidal Nanodelivery Systems, Techniques and Applications Publisher Pubmed



Enayati A1 ; Rezaei A2 ; Falsafi SR3 ; Rostamabadi H4 ; Malekjani N5 ; Akhavanmahdavi S6 ; Kharazmi MS7 ; Jafari SM6, 8, 9
Authors
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Authors Affiliations
  1. 1. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 81746–73461, Iran
  5. 5. Department of Food Science and Technology, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran
  6. 6. Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
  7. 7. Faculty of Medicine, University of California, Riverside, United States
  8. 8. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain
  9. 9. College of Food Science and Technology, Hebei Agricultural University, Baoding, 071001, China

Source: Food Chemistry Published:2023


Abstract

Bixin is the cis-carotenoid from the seed of achiote tree or annatto. It is an approved liposoluble apocarotenoid by FDA as colorant and additive in the food industry. Nonetheless, bixin is unstable in the presence of oxygen, light, high pHs (alkali) and heat; thereby reducing its bioavailability/bioactivity, and also, with a low solubility in water. Some biopolymeric (e.g., nanofibers, nanogels, and nanotubes) and lipid-based nanocarriers (nanoliposomes, niosomes, hexosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers) have been introduced for bixin. Thus, this review focuses on the updated information regarding bixin-loaded nanodelivery platforms. Moreover, it provides a comprehensive review of bioavailability, physicochemical properties, and applications of nanoencapsulated-bixin as an additive, its release rate and safety issues. These findings will bring potential strategies for the usage of nanocarriers in managing bixin defaults to improve its broad application in various industries. © 2023 Elsevier Ltd
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