Using Metabolomics to Investigate the Relationship Between the Metabolomic Profile of the Intestinal Microbiota Derivatives and Mental Disorders in Inflammatory Bowel Diseases: A Narrative Review Publisher

Summary: Review links gut bacteria imbalances in IBD to mental health issues via altered metabolites, suggesting new diagnostic tools. #IBD #MentalHealth

Zarei P¹ ; Sedeh PA² ; Vaez A^{1, 3} ; Keshteli AH⁴
Source: Research in Pharmaceutical Sciences Published:2025

Abstract

Individuals with inflammatory bowel disease (IBD) are at a higher risk of developing mental disorders, such as anxiety and depression. The imbalance between the intestinal microbiota and its host, known as dysbiosis, is one of the factors, disrupting the balance of metabolite production and their signaling pathways, leading to disease progression. A metabolomics approach can help identify the role of gut microbiota in mental disorders associated with IBD by evaluating metabolites and their signaling comprehensively. This narrative review focuses on metabolomics studies that have comprehensively elucidated the altered gut microbial metabolites and their signaling pathways underlying mental disorders in IBD patients. The information was compiled by searching PubMed, Web of Science, Scopus, and Google Scholar from 2005 to 2023. The findings indicated that intestinal microbial dysbiosis in IBD patients leads to mental disorders such as anxiety and depression through disturbances in the metabolism of carbohydrates, sphingolipids, bile acids, neurotransmitters, neuroprotective, inflammatory factors, and amino acids. Furthermore, the reduction in the production of neuroprotective factors and the increase in inflammation observed in these patients can also contribute to the worsening of psychological symptoms. Analyzing the metabolite profile of the patients and comparing it with that of healthy individuals using advanced technologies like metabolomics, aids in the early diagnosis and prevention of mental disorders. This approach allows for the more precise identification of the microbes responsible for metabolite production, enabling the development of tailored dietary and pharmaceutical interventions or targeted manipulation of microbiota. © 2025 Wolters Kluwer Medknow Publications. All rights reserved.