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The Role of Gut Microbiota in Human Metabolism and Inflammatory Diseases: A Focus on Elderly Individuals Publisher



Khaledi M1, 2 ; Poureslamfar B3 ; Alsaab HO4 ; Tafaghodi S5 ; Hjazi A6 ; Singh R7 ; Alawadi AH8 ; Alsaalamy A9 ; Qasim QA10 ; Sameni F1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
  2. 2. Department of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Department of Biology, Faculty of Science, Yasouj University, Yasouj, Iran
  4. 4. Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, 21944, Saudi Arabia
  5. 5. Department of Clinical Biochemistry, School of pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  7. 7. Department of Electronics & Communication Engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, 248007, India
  8. 8. College of technical engineering, the Islamic University, Najaf, Iraq
  9. 9. College of technical engineering, Imam Ja’afar Al‐Sadiq University, Al‐Muthanna, 66002, Iraq
  10. 10. College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq

Source: Annals of Microbiology Published:2024


Abstract

Background: The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body: Gut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption. Conclusion: The current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota. © 2023, The Author(s).
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