Prebiotics and Probiotics and Parkinson's Disease Publisher



Amani R¹ ; Mehrabani S¹ Show Affiliations
Source: Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders Published:2023

Abstract

Parkinson's disease (PD) is the second common neurodegenerative disease which occurs more at older ages characterized by motor dysfunction due to the loss of dopaminergic neurons in the substantia nigra. Also, PD patients have concomitant non-motor symptoms such as olfactory dysfunction, sleep disorders, and constipation that existed in several years’ earliest diagnosis of Parkinson. Gut microbiota alternation occurred among PD patients, which is correlated with the severity of motor symptoms. Gut dysbiosis can lead to increased intestinal permeability, which in turn contributes to inflammation, increased oxidative stress, and insulin resistance. All of these metabolic alternations can play a key role in the progression of Parkinson's disease. Therefore, alternative treatment based on intestinal microbiome restoration can help improve PD symptoms. For this reason, we reviewed gastrointestinal microbiota alternation in PD patients and reviewed clinical and preclinical studies on the use of probiotics and prebiotics therapy on disease status. © 2023 Elsevier Inc. All rights reserved.