Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Predicting of Trend of Hemoglobin A1c in Type 2 Diabetes: A Longitudinal Linear Mixed Model



Kazemi E1 ; Hosseini SM2 ; Bahrampour A1 ; Faghihimani E3 ; Amini M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biostatistics and Epidemiology, Research Center for Modeling in Health, Kerman University of Medical Sciences, Iran
  2. 2. Department of Biostatistics and Epidemiology, Skin Diseases and Stem Cell Research Centre, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Endocrinology and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2014

Abstract

Background: There are some evidences that control the blood sugar decreasing the risk of diabetes complications, and even fatal. There are so many studies, but they are mostly cross-sectional and ignore the trend and hence it is necessary to implement a longitudinal study. The aim of this prospective study is to find the trend of glycosylated hemoglobin (HbA1c) over time and the associative factors on it.; Methods: Participants of this longitudinal study were 3440 eligible diabetes patients referred to Isfahan Endocrine and Metabolism Research Center during 2000-2012 who are measured 2-40 times. A linear mixed model was applied to determine the association between HbA1c and variables, including lipids, systolic, diastolic blood pressure and complications such as nephropathy, and retinopathy. Furthermore, the effect of mentioned variables on trend of HbA1c was determined.; Results: The fitted model showed total cholesterol, retinopathy, and the method of therapy including oral antidiabetic drugs (OADs) plus insulin and insulin therapy decreased the trend of HbA1c and high-density lipoprotein, weight, hyperlipidemia and the method of therapy including diet, and OADs increased the trend of HbA1c.; Conclusions: The present study shows that regular visits of diabetic patients as well as controlling blood pressure, lipid profile, and weight loss can improve the trend of HbA1c levels during the time. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Accuracy of Glycosylated Hemoglobin a Index Measurement in Medical Laboratories in Isfahan City, Journal of Isfahan Medical School (2022)
2. Factors Related to Glycemic Control in Children and Adolescents With Type 1 Diabetes Mellitus in Isfahan, Iran, Journal of Diabetes and Metabolic Disorders (2021)
3. Current Status of Glucose, Blood Pressure and Lipid Management in Type 2 Diabetes Clinic Attendees in Isfahan, Iran, Journal of Diabetes Investigation (2015)
4. Incidence of Type 2 Diabetes by Hba1c and Ogtt: The Isfahan Diabetes Prevention Study, Acta Diabetologica (2012)
5. Benefits of Metformin Combined With Insulin in Children With Type 1 Diabetes Mellitus, Shiraz E Medical Journal (2011)
6. The Effect of Quality of Care on Cardiovascular Risk Factors in Newly Diagnosed Diabetic Patients, International Journal of Preventive Medicine (2014)
7. Effects of Diabetes Definition on Global Surveillance of Diabetes Prevalence and Diagnosis: A Pooled Analysis of 96 Population-Based Studies With 331 288 Participants, The Lancet Diabetes and Endocrinology (2015)
8. Glycated Hemoglobin As a Predictor for Metabolic Syndrome in an Iranian Population With Normal Glucose Tolerance, Metabolic Syndrome and Related Disorders (2012)
Experts (# of related papers)
View all Related Experts
Bijan Iraj (11)
Awat Feizi (11)
Other Related Docs
9. Does Bromocriptine Improve Glycemic Control of Obese Type-2 Diabetics?, Hormone Research (2004)
10. Comparison of Fasting Glucose With Post-Load Glucose Values and Glycated Hemoglobin for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2009)
11. The Effects of Oral Magnesium Supplementation on Glycaemic Control in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Controlled Clinical Trials, British Journal of Nutrition (2022)
12. Global Variation in Diabetes Diagnosis and Prevalence Based on Fasting Glucose and Hemoglobin A1c, Nature Medicine (2023)
13. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
14. Glycemic Control Among Iranian People With Type 2 Diabetes: A Systematic Review and Meta-Analysis, International Journal of Diabetes in Developing Countries (2023)
15. Effect of Pharmacist-Led Patient Education on Glycemic Control of Type 2 Diabetics: A Randomized Controlled Trial, Journal of Research in Medical Sciences (2011)
16. Dapagliflozin: An Effective Adjunctive Treatment in Type 1 Diabetes, Cardiovascular Endocrinology and Metabolism (2021)
17. Effect of Pharmacist-Led Patient Education on Glycemic Control of Type 2 Diabetics: A Randomized Controlled Trial, Journal of Research in Medical Sciences (2010)
18. Prevalence of Uncontrolled Diabetes and Its Predictors in Patients With Type 2 Diabetes Covered by Comprehensive Health Care Centers of Isfahan, Iranian Journal of Endocrinology and Metabolism (2022)
19. Weight Change, Blood Pressure, Lipids and Glycemic Control Among Patients With Type 2 Diabetes, Annals of Nutrition and Metabolism (2011)
20. The Freestyle Libre Flash Glucose Monitoring System: How It Has Improved Glycaemic Control for People With Type 1 Diabetes in Eastern Cheshire, Uk, Cardiovascular Endocrinology and Metabolism (2020)
21. The Relationship Between Serum Ldl-Cholesterol, Hdl-Cholesterol and Systolic Blood Pressure in Patients With Type 2 Diabetes, Kardiologia Polska (2006)
22. Effects of Eicosapentaenoic Acid and Vitamin C on Glycemic Indices, Blood Pressure, and Serum Lipids in Type 2 Diabetic Iranian Males, Journal of Research in Medical Sciences (2011)
23. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
24. Neck Circumference in Relation to Glycemic Parameters: A Systematic Review and Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2019)
25. Variations in Diabetes Prevalence in Low-, Middle-, and High-Income Countries: Results From the Prospective Urban and Rural Epidemiological Study, Diabetes Care (2016)
26. The Effect of Psyllium on Fasting Blood Sugar, Hba1c, Homa Ir, and Insulin Control: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Endocrine Disorders (2024)
27. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
28. Drug Use Evaluation of Diabetes Mellitus in Non-Hospitalized Patients, International Journal of Pharmacy and Pharmaceutical Sciences (2016)
29. Diabetes Mellitus and Renal Failure: Prevention and Management, Journal of Research in Medical Sciences (2015)
30. A Comparative Study of the Effect of Two Procedures of Classic Roux-En-Y and Omega Bariatric Surgery on the Control and Management of Diabetes, Advanced Biomedical Research (2022)
31. The Relationship Between Hematologic Variables and Metabolic Syndrome, Iranian Heart Journal (2011)
32. Metabolic Syndrome in First Degree Relatives of Patients With Type 2 Diabetes: Incidence and Risk Factors, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2011)
33. Comparison of Gestational Diabetes Mellitus and Pre-Eclampsia in Women With High Hemoglobin in the First Trimester of Pregnancy: A Longitudinal Study, Pakistan Journal of Medical Sciences (2013)
34. Effect of Sitagliptin on Proteinuria in Patients With Type 2 Diabetes-A Renoprotective Effect of Sitagliptin, Journal of Research in Medical Sciences (2021)
35. Brewer's Yeast Improves Glycemic Indices in Type 2 Diabetes Mellitus, International Journal of Preventive Medicine (2013)
36. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
37. Retinopathy in Newly Diagnosed Typ 2 Diabetec Patients in Isfahan, Prevalence and Risk Factors, Iranian Journal of Diabetes and Lipid Disorders (2006)
38. Comparison of Body Mass Index With Abdominal Obesity Indicators and Waist-To-Stature Ratio for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Obesity Research and Clinical Practice (2010)
39. Gaba Dramatically Improves Glucose Tolerance in Streptozotocin-Induced Diabetic Rats Fed With High-Fat Diet, European Journal of Pharmacology (2018)
40. Effect of Curcumin on Glycemic Control in Patients With Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials, Advances in Experimental Medicine and Biology (2021)
41. Glucose and the Risk of Hypertension in First-Degree Relatives of Patients With Type 2 Diabetes, Hypertension Research (2015)
42. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
43. Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Glycemic Control and Markers of Lipid Profiles in Diabetic Hemodialysis Patients, International Urology and Nephrology (2018)
44. Prevalence of Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Patients in Isfahan, Iran, Acta Endocrinologica (2008)
45. Cross-Sectional and Longitudinal Assessments of Risk Factors Associated With Hypertension and Moderately Increased Albuminuria Comorbidity in Patients With Type 2 Diabetes: A 9-Year Open Cohort Study, Diabetes, Metabolic Syndrome and Obesity (2019)
46. The Effects of Macronutrient Intake on the Risk of Pre-Diabetes in First- Degree Relatives of Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2014)
47. Hypertension in Type 2 Diabetes Mellitus in Isfahan, Iran: Incidence and Risk Factors, Diabetes Research and Clinical Practice (2005)
48. The Effect of Salsalate on Biochemical Factors and Endothelial Dysfunction of Prediabetic Patients: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2014)
49. Comparison of Dietary Intake Between Children With Type1 Diabetes Mellitus and Control Group, Iranian Journal of Diabetes and Lipid Disorders (2005)
50. Effect of Magnesium Sulfate Administration to Improve Insulin Resistance in Type 2 Diabetes Animal Model: Using the Hyperinsulinemic-Euglycemic Clamp Technique, Fundamental and Clinical Pharmacology (2018)