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Comparison of Oral Candidiasis Characteristics in Head-And-Neck Cancer Patients Before and During Radiotherapy Publisher



Golestannejad Z1 ; Khozeimeh F1 ; Najafizade N2 ; Tabesh A1 ; Faghihian E1 ; Maheronnaghsh M3 ; Kheirkhah M3 ; Hosseini S4 ; Sadeghalbanaei L5 ; Jamshidi M6 ; Chermahini A7 ; Saberi Z1 ; Pakravan F8 ; Dehghan P9 Show All Authors
Authors
  1. Golestannejad Z1
  2. Khozeimeh F1
  3. Najafizade N2
  4. Tabesh A1
  5. Faghihian E1
  6. Maheronnaghsh M3
  7. Kheirkhah M3
  8. Hosseini S4
  9. Sadeghalbanaei L5
  10. Jamshidi M6
  11. Chermahini A7
  12. Saberi Z1
  13. Pakravan F8
  14. Dehghan P9
  15. Emamibafrani M10
  16. Amini N11
  17. Tadayon F10
Show Affiliations
Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Medicine, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Orthodontics, Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Periodontics, Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Endodontics, Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. Department of Oral and Maxillofacial Medicine, Dental Implants Research Center, School of Dentistry, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Dentist, Dental Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Department of Pediatric Dentistry, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Source: Dental Research Journal Published:2023


Abstract

Background: Patients undergoing head-and-neck radiotherapy are susceptible to Candida colonization and infection. This study aimed to identify oral Candida species type (ST), colony count (CC), and oropharyngeal candidiasis (OPC) in head-and-neck cancer patients, undergoing radiotherapy, before and 2 weeks after radiation. Materials and Methods: In this quasi-experimental study, head-and-neck cancer patients undergoing radiotherapy (up to 6000 cGy) were recruited. Samples were taken before and 2 weeks after radiation therapy (RT). CC was assigned using Sabouraud dextrose agar culture medium and morphological studies were performed to confirm OPC. For identification, polymerase chain reaction-restriction fragment length polymorphism was performed. Data were analyzed using Chi-square-test and kappa coefficient. P < 0.05 was considered statistically significant. Results: Twenty-one of 33 patients were Candida positive. The detected fungal species included Candida albicans (60%), Candida tropicalis (22%), Candida glabrata (9%), and other species (9%). Following RT, OPC and CC changed significantly (P = 0.003 and P = 0.001, respectively), whereas ST did not significantly change (P = 0.081). Two new species (Candida krusei and Candida parapsilosis) were detected after the intervention. The OPC, CC, and ST changes after RT were not significantly related to malignancy site or radiation dose (P > 0.05). Conclusion: The present study showed that OPC, CC, and ST were not related to the malignancy site. Following RT, OPC and CC changed significantly, while ST showed no significant change. The radiation dose and malignancy site had no effects on the OPC, CC, or ST alterations following RT. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
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