Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Frequency of Oral Candidiasis in Children and Adolescents With Leukemia in Isfahan Province, Iran



Aghadavoudi F1 ; Chabavizadeh J1 ; Dehghan P1 ; Moafi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: Oral candidiasis is one of the most important and common opportunistic fungal infections especially in patients with leukemia, and other kind of cancers. This study aimed to isolate and determine the frequency of common species of Candida in children and adolescents with leukemia in Isfahan province, Iran, in order to provide some ways for prevention and using short-term treatment for them. Methods: In this study, 72 oral samples were obtained from the mouth lesions of the children and adolescents with leukemia hospitalized in Seyed al Shohada hospital in Isfahan city. Two wet sterile swabs were used for sampling, one for direct exam and the second for culturing on CHROMagar candida, and Sabouraud Dextrose agar with chloramphenicol. For more accurate determination of the species, molecular methods such as polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using Msp1 enzyme were done. Findings: Out of 72 patients with oral lesions, 21 patients (29.2%) had oral candidiasis The frequency of candida species were as 17 cases of Candida albicans (81.0%), 2 cases of Candida glabrata (9.5%), and 1 case of Candida krusei (4.8%) and 1 case of Candida kefyr (4.8%). Conclusion: This study showed that Candida albicans is the most common identified species. Considering that chemotherapy makes the patients susceptible to fungal infections such as candidiasis, early detection of these agents can be useful to control the infection and have a short-term treatment process. © 2017, (publisher Name). All rights reserved.
Related Docs
View other Related Docs
1. Species Distribution and Susceptibility Profiles of Oral Candidiasis in Hematological Malignancy and Solid Tumor Patients, Brazilian Journal of Microbiology (2023)
2. Identification of Candida Species and Antifungal Susceptibility in Cancer Patients With Oral Lesions in Ahvaz, Southern West of Iran, Advanced Biomedical Research (2020)
3. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
4. Evaluation and Comparison of Antifungal Effect of Voriconazole With Nystatin on Candida Species Derived From Neoplastic Patients Undergoing Maxillofacial Radiotherapy, Dental Research Journal (2023)
5. Identification of Candida Species in Oral Cavity of Smokers and Nonsmokers, Journal of Isfahan Medical School (2016)
6. Frequency of Candida Species in the Oral Cavity of Narcotics and Stimulants Smokers in Isfahan, Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method, Advanced Biomedical Research (2020)
7. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
8. Frequency of Candida Species Isolated From Patients in Children’S Medical Center, Tehran, Iran, Archives of Pediatric Infectious Diseases (2018)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (37)
Seyed Hossein Mirhendi Esfahani (31)
Other Related Docs
9. Cross-Sectional Study of Candidemia From Isfahan, Iran: Etiologic Agents, Predisposing Factors, and Antifungal Susceptibility Testing, Journal of Research in Medical Sciences (2021)
10. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
11. Candida Infections Among Neutropenic Patients, Caspian Journal of Internal Medicine (2016)
12. Comparison of Virulence Factors of Different Candida Species Isolated From the Oral Cavity of Cancer Patients and Normal Individuals, Jundishapur Journal of Microbiology (2019)
13. The Frequency of Candiduria in Hospitalized Patients at Nephrology Department, Labbafinejad Hospital, Tehran, Iran, Journal of Isfahan Medical School (2017)
14. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
15. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
16. Microbial Epidemiology of Candidaemia in Neonatal and Paediatric Intensive Care Units at the Children's Medical Center, Tehran, Mycoses (2018)
17. Molecular Characterization of Candida Dubliniensis and Candida Albicans in the Oral Cavity of Drug Abusers Using Duplex Polymerase Chain Reaction, Current Medical Mycology (2018)
18. The Matching Rate of the Frequency of the Isolated Candida Species Calculated by Morphological and Molecular Methods in Patients With Vaginitis, Journal of Isfahan Medical School (2017)
19. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)
20. Identification of Candida Species Isolated From Candiduria Patients Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism in Isfahan, Iran, Journal of Isfahan Medical School (2016)
21. Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered From Oral Cavity Among Patients With Diabetes Mellitus From Tehran, Iran, Advanced Biomedical Research (2022)
22. Comparison of Oral Candidiasis Characteristics in Head-And-Neck Cancer Patients Before and During Radiotherapy, Dental Research Journal (2023)
23. The Evaluation of the Overexpression of the Erg-11, Mdr-1, Cdr-1, and Cdr-2 Genes in Fluconazole-Resistant Candida Albicans Isolated From Ahvazian Cancer Patients With Oral Candidiasis, Journal of Clinical Laboratory Analysis (2022)
24. Identification and Frequency of Candida Species in Patients With Different Forms of Candidiasis in Isfahan, Using Pcr-Rflp Method, Journal of Isfahan Medical School (2011)
25. Candidemia in Children Caused by Uncommon Species of Candida, Archives of Pediatric Infectious Diseases (2018)
26. Invasive Fungal Infection in Febrile Patients With Hematologic Malignancies Undergoing Chemotherapy in Iran, Endocrine, Metabolic and Immune Disorders - Drug Targets (2019)
27. Diagnosis of Candida Species Isolated From Patients With Vaginal Candidiasis and Healthy Individuals Based on Clinical Symptoms and Paraclinical Evidences, Journal of Isfahan Medical School (2012)
28. Detection of Candida Albicans in Oral Squamous Cell Carcinoma by Fluorescence Staining Technique, Dental Research Journal (2015)
29. Translation Elongation Factor 1-Alpha Gene As a Marker for Diagnosing of Candidal Onychomycosis, Current Medical Mycology (2020)
30. Molecular Characterization and Antifungal Susceptibilitytesting of Candida Nivariensis From Blood Samples – an Iranian Multicentre Study and a Review of the Literature, Journal of Medical Microbiology (2019)
31. Frequency of Candida Species Isolated From the Oral Cavity of Hiv-Infected Patients Referring to Behavioral Disease Counseling Center of Isfahan in 2017-2018, Scientific Journal of Kurdistan University of Medical Sciences (2019)
32. Epidemiology, Species Distribution, Antifungal Susceptibility, and Outcome of Candidemia in Intensive Care Units in Isfahan, Iran, Current Medical Mycology (2022)
33. Molecular Epidemiology and Antifungal Susceptibility Profile in Nakaseomyces Glabrata Species Complex: A 5-Year Countrywide Study, Journal of Clinical Laboratory Analysis (2024)
34. Catheter-Associated Blood Stream Infections Due to Candida Pararugosa in a Patient With Acute Myeloid Leukemia: A Case Report, Brazilian Journal of Microbiology (2023)
35. Molecular Identification of Candida Species Isolated From Gastrooesophageal Candidiasis in Tehran, Iran, Gastroenterology and Hepatology from Bed to Bench (2015)
36. Yeast Species in the Respiratory Samples of Covid-19 Patients; Molecular Tracking of Candida Auris, Frontiers in Cellular and Infection Microbiology (2024)
37. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)
38. Frequency of Uncommon Clinical Yeast Species Confirmed by Its-Sequencing, Archives of Clinical Infectious Diseases (2019)
39. Utilization of Size Polymorphism in Its1 and Its2 Regions for Identification of Pathogenic Yeast Species, Journal of Medical Microbiology (2017)
40. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
41. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
42. Molecular Identification and Antifungal Susceptibility Profiles of Etiologic Agents of Oral Candidiasis Among Hiv-Positive Patients: A Multicenter Study, Current Medical Mycology (2023)
43. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
44. Clinical and Mycological Study of Vulvovaginal Candidiasis (Vvc); Identification of Clinical Isolates by Polymerase Chain Reaction-Fragment Size Polymorphyim (Pcr-Fsp) Technique, Archives of Clinical Infectious Diseases (2017)
45. Differentiation of Candida Albicans Complex Species Isolated From Invasive and Non-Invasive Infections Using Hwp1 Gene Size Polymorphism, Current Medical Mycology (2021)
46. Direct Detection and Identification of the Most Common Bacteria and Fungi Causing Otitis Externa by a Stepwise Multiplex Pcr, Frontiers in Cellular and Infection Microbiology (2021)
47. Functional Analysis of Two Stat1 Gain-Of-Function Mutations in Two Iranian Families With Autosomal Dominant Chronic Mucocutaneous Candidiasis, Medical Mycology (2021)
48. Candida Africana Vulvovaginitis: Prevalence and Geographical Distribution, Journal de Mycologie Medicale (2020)
49. Rapid Detection of Candida Species in Bronchoalveolar Lavage Fluid From Patients With Pulmonary Symptoms, Brazilian Journal of Microbiology (2016)
50. Evaluation of Rapid Diagnosis of Candidemia by Agglutination Test Using Gold Nanoparticles, Journal of Isfahan Medical School (2022)