Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation and Comparison of Antifungal Effect of Voriconazole With Nystatin on Candida Species Derived From Neoplastic Patients Undergoing Maxillofacial Radiotherapy Publisher



Khozeimeh F1 ; Nezhad ZG1 ; Dehghan P2 ; Tabesh A1 ; Kheirkhah M3 ; Jamshidi M4 ; Chermahini AA5 ; Sadeghalbanaei L6 ; Golestannejad Z1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Medicine, Dental Research Center, School of Dentistry, Dental Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Department of Periodontology, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
  5. 5. Department of Endodontics, Student Research Committee, Qazvin University of Medical Science, Qazvin, Iran
  6. 6. Department of Orthodontics, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran

Source: Dental Research Journal Published:2023


Abstract

Background: Radiotherapy is a common treatment for head-and-neck malignancies and causes complications such as oral candidiasis and the change of oral Candida species from albicans to nonalbicans. Voriconazole has acceptable antifungal effect. The aim of this study was to determine and compare the antifungal effect of nystatin with voriconazole on these species. Materials and Methods: The samples used in this in vitro study were identified by polymerase chain reaction-restriction fragment length polymorphism from patients before and 2 weeks after head-and-neck radiotherapy in Seyed Al-Shohada Hospital. The antifungal effect of nystatin and voriconazole was determined by microdilution method and measurement of the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration, and the results were analyzed by Mann-Whitney analysis. Results: The results showed that all species before and after radiotherapy showed 100% sensitivity to nystatin. Prior to radiotherapy, 57.1% of albicans species isolated were in the sensitive range (MIC ≤1) and 42.9% were in the dose-dependent range (MIC = 2) to voriconazole. After radiotherapy, 58.3% of albicans species were in the sensitive range and 41.7% of these species were in the dose-dependent range to voriconazole. Conclusion: The results of the present study showed that before radiotherapy, all species were sensitive to nystatin, while a percentage of albicans and nonalbicans were resistant to voriconazole. In the 2 nd week of radiotherapy similar to prior to radiotherapy, all species isolated from patients were sensitive to nystatin, while a percentage of albicans and nonalbicans were resistant to voriconazole. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
Related Docs
View other Related Docs
1. Evaluation of Antifungal Effect of Amphotericin B in Comparison With Nystatin on Candida Species Derived From Patients Undergoing Head‑And‑Neck Radiotherapy, Dental Research Journal (2024)
2. Antifungal Effect of Atorvastatin in Comparison With Fluconazole on Candida Species Isolated From Patients Undergoing Head‑And‑Neck Radiotherapy, Dental Research Journal (2024)
3. Comparison of Oral Candidiasis Characteristics in Head-And-Neck Cancer Patients Before and During Radiotherapy, Dental Research Journal (2023)
4. Identification of Candida Species and Antifungal Susceptibility in Cancer Patients With Oral Lesions in Ahvaz, Southern West of Iran, Advanced Biomedical Research (2020)
5. Species Distribution and Susceptibility Profiles of Oral Candidiasis in Hematological Malignancy and Solid Tumor Patients, Brazilian Journal of Microbiology (2023)
6. In Vitro Activity of Juglone (5-Hydroxy-1,4-Naphthoquinone) Against Both Fluconazole-Resistant and Susceptible Candida Isolates; [Actividad in Vitro De Juglona (5-Hidroxi-1,4-Naftoquinona) Contra Aislamientos De Candida Resistentes Y Sensibles a Fluconazol], Revista Iberoamericana de Micologia (2022)
7. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
8. The Frequency of Oral Candidiasis in Children and Adolescents With Leukemia in Isfahan Province, Iran, Journal of Isfahan Medical School (2017)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (30)
Seyed Hossein Mirhendi Esfahani (17)
Other Related Docs
9. Antifungal Effect of Atorvastatin Against Candida Species in Comparison to Fluconazole and Nystatin, Medicine and Pharmacy Reports (2019)
10. Invasive Fungal Infection in Febrile Patients With Hematologic Malignancies Undergoing Chemotherapy in Iran, Endocrine, Metabolic and Immune Disorders - Drug Targets (2019)
11. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
12. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
13. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
14. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
15. The Evaluation of the Overexpression of the Erg-11, Mdr-1, Cdr-1, and Cdr-2 Genes in Fluconazole-Resistant Candida Albicans Isolated From Ahvazian Cancer Patients With Oral Candidiasis, Journal of Clinical Laboratory Analysis (2022)
16. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
17. Differentiation of Candida Albicans Complex Species Isolated From Invasive and Non-Invasive Infections Using Hwp1 Gene Size Polymorphism, Current Medical Mycology (2021)
18. Fungal Presence and Health Implications in Hospital Water Systems, International Journal of Environmental Health Research (2024)
19. In Vitro Antifungal Susceptibility Profile of Miltefosine Against a Collection of Azole and Echinocandins Resistant Fusarium Strains, Journal of Fungi (2022)
20. Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole, Journal of Isfahan Medical School (2015)
21. Species Identification and in Vitro Antifungal Susceptibility Testing of Aspergillus Section Nigri Strains Isolated From Otomycosis Patients, Journal de Mycologie Medicale (2018)
22. Detection of Erg11 Point Mutations in Iranian Fluconazole-Resistant Candida Albicans Isolates, Current Medical Mycology (2019)
23. Clinical and Mycological Study of Vulvovaginal Candidiasis (Vvc); Identification of Clinical Isolates by Polymerase Chain Reaction-Fragment Size Polymorphyim (Pcr-Fsp) Technique, Archives of Clinical Infectious Diseases (2017)
24. Identification and Frequency of Candida Species in Patients With Different Forms of Candidiasis in Isfahan, Using Pcr-Rflp Method, Journal of Isfahan Medical School (2011)
25. Evaluation of the Effects of Photodynamic Therapy With Methylene Blue on Different Candida Species in Vitro, Journal of Lasers in Medical Sciences (2023)
26. An Alarming Rise of Non-Albicans Candida Species and Uncommon Yeasts in the Clinical Samples; a Combination of Various Molecular Techniques for Identification of Etiologic Agents, BMC Research Notes (2019)
27. Molecular Identification and Antifungal Susceptibility Profiles of Etiologic Agents of Oral Candidiasis Among Hiv-Positive Patients: A Multicenter Study, Current Medical Mycology (2023)
28. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
29. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
30. Preparation and in Vitro Evaluation of Inhalation Powder Containing Fluconazole Nanoparticles for the Treatment of Fungal Lung Infections, Journal of Isfahan Medical School (2023)
31. Amino Acid Substitutions in Erg11p of Azole-Resistant Candida Glabrata: Possible Effective Substitutions and Homology Modelling, Journal of Global Antimicrobial Resistance (2016)
32. Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered From Oral Cavity Among Patients With Diabetes Mellitus From Tehran, Iran, Advanced Biomedical Research (2022)
33. Antifungal Activity of Almond (Prunus Amygdalus) Hull Extracts Against Clinical Isolates of Candida Albicans, Current Medical Mycology (2024)
34. Evaluation of the Antifungal Effect of Fluconazole Separately and With Coriander Essential Oil on Candida Species Isolated From the Mouth of Hiv-Positive Individuals, Scientific Journal of Kurdistan University of Medical Sciences (2023)
35. Identification of Candida Species Isolated From Candiduria Patients Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism in Isfahan, Iran, Journal of Isfahan Medical School (2016)
36. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)
37. The Effects of Nutraceuticals and Herbal Medicine on Candida Albicans in Oral Candidiasis: A Comprehensive Review, Advances in Experimental Medicine and Biology (2021)
38. Immunomodulatory Drug Fingolimod (Fty720) Restricts the Growth of Opportunistic Yeast Candida Albicans in Vitro and in a Mouse Candidiasis Model, PLoS ONE (2022)
39. The Survey of Fungal Wounds Infections in Burn Patients in Isfahan, Iran, Journal of Isfahan Medical School (2017)
40. Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film, Journal of Reports in Pharmaceutical Sciences (2013)
41. Synthetic Approaches and Structural Diversity of Triazolylbutanols Derived From Voriconazole in the Antifungal Drug Development, European Journal of Medicinal Chemistry (2022)
42. Anti Candidal Activity of Echinophora Platyloba Against Candida Albicans and Comparison With Amphotricin, Journal of Medicinal Plants (2009)
43. Candida Africana Vulvovaginitis: Prevalence and Geographical Distribution, Journal de Mycologie Medicale (2020)
44. Molecular Characterization of Candida Dubliniensis and Candida Albicans in the Oral Cavity of Drug Abusers Using Duplex Polymerase Chain Reaction, Current Medical Mycology (2018)
45. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
46. Otomycosis in Central Iran: A Clinical and Mycological Study, Iranian Red Crescent Medical Journal (2011)
47. The Frequency of Candiduria in Hospitalized Patients at Nephrology Department, Labbafinejad Hospital, Tehran, Iran, Journal of Isfahan Medical School (2017)
48. Strategies for Isothermal Amplification of Nucleic Acids: Are They Ready to Be Applied in Point of Care Diagnosis of Mycosis?, Biointerface Research in Applied Chemistry (2021)
49. In-Vivo Efficiency of the Novel Azole Compounds (Attaf-1 and Attaf-2) Against Systemic Candidiasis in a Murine Model, Journal of Medical Mycology (2023)
50. Antifungal Activity of a Novel Triazole, Efinaconazole and Nine Comparators Against 354 Molecularly Identified Aspergillus Isolates, Mycopathologia (2020)