Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Antifungal Effect of Amphotericin B in Comparison With Nystatin on Candida Species Derived From Patients Undergoing Head‑And‑Neck Radiotherapy Publisher



Golestannejad Z1 ; Saberi Z1 ; Jamshidi M2 ; Dehghan P3 ; Khozeimeh F1 ; Faghihian E1 ; Najafizadeh N4 ; Maheronnaghsh M3 ; Chermahini AA5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Oral Medicine, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Periodontics, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Departments of Mycology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Departments of Radio Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Endodontics, Kashan University of Medical Sciences, Kashan, Iran

Source: Dental Research Journal Published:2024


Abstract

Background: There is ample evidence showing the development of nystatin‑resistant strains in patients undergoing malignancy treatment.Amphotericin B is a polyene antifungal drug that combines with ergosterol to cause cell death and is more effective on fungal species than routine antifungals such as nystatin.This study aimed to compare the effect of nystatin and amphotericin B on fungal species isolated from patients before and during head‑and‑neck radiotherapy. Materials and Methods: This in vitro experimental study was performed on samples isolated from patients undergoing head‑and‑neck radiotherapy before and during radiotherapy at Sayed al‑Shohada Hospital in Isfahan, Iran.The isolates were identified by polymerase chain reaction‑restriction fragment length polymorphism. Antifungal effects were determined by the microdilution method based on clinical and laboratory standards institute standards and minimum inhibitory concentration (MIC), minimum lethal concentration (MFC), drug sensitivity, and resistance were measured.The data were analyzed by SPSS version 22 (level of significance: 0.05). Results: Before radiotherapy, all albicans strains were sensitive to nystatin, whereas 71.4% were sensitive to amphotericin B. After radiotherapy, Candida albicans strains were 100% sensitive to nystatin and 75% sensitive to amphotericin B. Conclusion: The present study showed that before radiotherapy, all species isolated from patients, including C. albicans, C. tropicalis, and C. glabrata, were sensitive to nystatin, whereas a percentage of albicans species showed resistance to amphotericin B. In the 2nd week of radiotherapy, the same as before radiotherapy, all species isolated from patients were sensitive to nystatin, whereas a percentage of albicans species showed resistance to amphotericin B. In general, the current study showed that before and after radiotherapy, the antifungal effect of nystatin is greater than amphotericin B. © 2024 Dental Research Journal.
Related Docs
View other Related Docs
1. Evaluation and Comparison of Antifungal Effect of Voriconazole With Nystatin on Candida Species Derived From Neoplastic Patients Undergoing Maxillofacial Radiotherapy, Dental Research Journal (2023)
2. Comparison of Oral Candidiasis Characteristics in Head-And-Neck Cancer Patients Before and During Radiotherapy, Dental Research Journal (2023)
3. Antifungal Effect of Atorvastatin in Comparison With Fluconazole on Candida Species Isolated From Patients Undergoing Head‑And‑Neck Radiotherapy, Dental Research Journal (2024)
4. Identification of Candida Species and Antifungal Susceptibility in Cancer Patients With Oral Lesions in Ahvaz, Southern West of Iran, Advanced Biomedical Research (2020)
5. Antifungal Effect of Atorvastatin Against Candida Species in Comparison to Fluconazole and Nystatin, Medicine and Pharmacy Reports (2019)
6. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
7. The Evaluation of the Overexpression of the Erg-11, Mdr-1, Cdr-1, and Cdr-2 Genes in Fluconazole-Resistant Candida Albicans Isolated From Ahvazian Cancer Patients With Oral Candidiasis, Journal of Clinical Laboratory Analysis (2022)
8. Invasive Fungal Infection in Febrile Patients With Hematologic Malignancies Undergoing Chemotherapy in Iran, Endocrine, Metabolic and Immune Disorders - Drug Targets (2019)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (13)
Parvin Dehghan (8)
Other Related Docs
9. In Vitro Antifungal Susceptibility Profile of Miltefosine Against a Collection of Azole and Echinocandins Resistant Fusarium Strains, Journal of Fungi (2022)
10. Species Distribution and Susceptibility Profiles of Oral Candidiasis in Hematological Malignancy and Solid Tumor Patients, Brazilian Journal of Microbiology (2023)
11. Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole, Journal of Isfahan Medical School (2015)
12. Species Identification and in Vitro Antifungal Susceptibility Testing of Aspergillus Section Nigri Strains Isolated From Otomycosis Patients, Journal de Mycologie Medicale (2018)
13. Detection of Erg11 Point Mutations in Iranian Fluconazole-Resistant Candida Albicans Isolates, Current Medical Mycology (2019)
14. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
15. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
16. The Frequency of Oral Candidiasis in Children and Adolescents With Leukemia in Isfahan Province, Iran, Journal of Isfahan Medical School (2017)
17. The Survey of Fungal Wounds Infections in Burn Patients in Isfahan, Iran, Journal of Isfahan Medical School (2017)
18. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
19. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
20. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
21. Premedication Drugs' Evaluation and Incidence of Infusion-Related Reactions in Patients Receiving Amphotericin B, Tehran University Medical Journal (2020)
22. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
23. Strategies for Isothermal Amplification of Nucleic Acids: Are They Ready to Be Applied in Point of Care Diagnosis of Mycosis?, Biointerface Research in Applied Chemistry (2021)
24. In-Vivo Efficiency of the Novel Azole Compounds (Attaf-1 and Attaf-2) Against Systemic Candidiasis in a Murine Model, Journal of Medical Mycology (2023)
25. Trends in the Prevalence of Amphotericin B-Resistance (Ambr) Among Clinical Isolates of Aspergillus Species, Journal of Medical Mycology (2022)
26. Invasive Fungal Infections in Hematologic Malignancies: Incidence, Management, and Antifungal Therapy, Journal of Research in Medical Sciences (2023)
27. Candida Infections Among Neutropenic Patients, Caspian Journal of Internal Medicine (2016)
28. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
29. Cross-Sectional Study of Candidemia From Isfahan, Iran: Etiologic Agents, Predisposing Factors, and Antifungal Susceptibility Testing, Journal of Research in Medical Sciences (2021)
30. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
31. In Vitro Activity of Juglone (5-Hydroxy-1,4-Naphthoquinone) Against Both Fluconazole-Resistant and Susceptible Candida Isolates; [Actividad in Vitro De Juglona (5-Hidroxi-1,4-Naftoquinona) Contra Aislamientos De Candida Resistentes Y Sensibles a Fluconazol], Revista Iberoamericana de Micologia (2022)
32. Comparison of in Vitro Activities of Newer Triazoles and Classic Antifungal Agents Against Dermatophyte Species Isolated From Iranian University Hospitals: A Multi-Central Study, Annals of Clinical Microbiology and Antimicrobials (2023)
33. In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared With Those of Five Antifungal Drugs Against Melanized Fungi and Relatives, Antimicrobial Agents and Chemotherapy (2017)
34. Multicenter Study of Susceptibility of Aspergillus Species Isolated From Iranian University Hospitals to Seven Antifungal Agents, Microbiology Spectrum (2022)
35. In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex, Mycopathologia (2016)