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The Reno-Protective Role of Angiotensin 1-7 in Cisplatin Induced Nephrotoxicity



Pezeshki Z1 ; Karimi F1 ; Kassaei S1 ; Choopani S1 ; Talebi A1, 2 ; Nematbakhsh M1, 3, 4
Authors
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Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Source: Kuwait Medical Journal Published:2020

Abstract

Objective: To determine the protective role of angiotensin 1-7 (Ang1-7) against Cisplatin (CP) induced nephrotoxicity Design: Case-control animal experimental study Setting: Water and Electrolytes Research Center/Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran Subjects: 35 male (331±7.4 g) and female (196.5±5.9 g) Wistar rats Interventions: The rats were subject to treatment with vehicle, single dose of CP alone (7.5 mg/kg) or a single dose of CP plus daily infusion of Ang1-7 (30 µg/kg/day). The measurements were performed one week after CP administration. Main outcome measures: Serum levels of blood urea nitrogen (BUN), creatinine (Cr) and malondialdehyde, kidney tissue damage score and normalized kidney weight Results: The increased kidney tissue damage, kidney weight, and the serum levels of BUN and Cr induced by CP was attenuated significantly by Ang1-7 (P <.05) in male rats. However, the protective role of Ang1-7 against CP induced nephrotoxicity was not detected in female rats. Conclusion: Ang1-7 may act as suitable supplement to attenuate CP induced nephrotoxicity in male rats, possibly due to its effect on kidney circulation. © 2020, Kuwait Medical Association. All rights reserved.
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