Cardiovascular Baroreflex Sensitivity Attenuates by Cisplatin-Induced Toxicity in Rats



Nematbakhsh M^{1, 2, 3} ; Azarkish F^{1, 4} ; Poorshahnazari AA²
Source: Physiology and Pharmacology Published:2015

Abstract

Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups; treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical procedure to determine BRS using three different doses (0.025, 0.05 and 0.1 mg/kg) of α-adrenergic receptor agonist phenylephrine (PE). Results: Serum levels of blood urea nitrogen and creatinine, kidney weight, and kidney tissue damage score were increased in CP-treated animals. All doses of PE injection caused MAP increase and HR decrease. However, ΔMAP and ΔHR response to 0.1 mg/kg of PE were significantly lower in the CP-treated group (P<0.05). BRS also was increased in a dosedependent manner by PE in vehicle-treated group, but this was not the case in the CP-treated animals, and significant difference in BRS was detected between the two groups (P<0.05) when 0.05 or 0.1 mg/kg of PE were infused. Conclusion: CP-induced nephrotoxicity attenuates BRS possibly due to peripheral effect on the vascular system. © 2015, Iranian Society of Physiology and Pharmacology. All rights reserved.