Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of the Effect of Hydroalcoholic Extract of Dracocephalum Kotschyi Boiss on Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats; [اثر عصارهی هیدروالکلی زرین گیاه بر فیبروز کبدی ناشی از تتراکلرید کربن در رتهای نر بالغ] Publisher



Atabak M1 ; Hosseinisharifabad A1 ; Sadraei H1 ; Mohammadalipour A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2022


Abstract

Background: Liver disease eventually leads to fibrosis, which is a type of collagenized tissue. D.kotschyi has compounds that have strong anti-inflammatory and anti-fibrotic properties. Due to the inflammatory nature of fibrosis, this study aims to investigate the effect of different doses of hydroalcoholic extract of D.kotschyi on liver fibrosis induced by carbon tetrachloride. Methods: The D.kotschyi hydroalcoholic extract was prepared via maceration method in 70% ethanol. The groups (6 adult male rats in each) of animals included: Sham, Control, Tetrachloride carbon (CCl4), vitamin E as well as extracts plus CCl4. The extract of D.kotschyi was gavaged at 20, 40 or 80 mg/kg. In addition, the diluted CCl4 in olive oil (1:1) was injected at 1ml/kg intraperitoneally. The duration of treatment was 1 month. Then the blood sample and liver tissue of rats were extracted for biochemical and pathological examination. Findings: Administration of the D.kotschyi for 1 month significantly reduced the level of Alkaline phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) liver enzymes compared to CCl4 treated group (P < 0.001) as well as caused a significant improvement in the pathological features of fibrosis. Conclusion: The present study showed a significant reduction in the amount of hepatic fibrosis caused by carbon tetrachloride in the pathology samples receiving the D.kotschyi extract. In addition, by increasing dose of the D.kotschyi, a significant decrease in liver enzymes was observed. The effect of the D.kotschyi in improving fibrosis at higher doses requires extensive studies. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Biochemical and Hematological Parameters in Rat; [تأثیر عصارهی هیدروالکلی Kotschyi Dracocephalum روی پارامترهای بیوشیمیایی و هماتولوژیک رات], Journal of Isfahan Medical School (2022)
2. Inhibitory Effect of Hydroalcoholic and Flavonoids Extracts of Dracocephalum Kotschyi, and Its Components Luteolin, Apigenin and Apigenin-4'-Galactoside on Intestinal Transit in Mice, Journal of HerbMed Pharmacology (2019)
3. Effect of Hydroalcoholic and Aqueous Extracts of Dracocephalum Kotschyi on Bleomycin Induced Pulmonary Fibrosis, Journal of HerbMed Pharmacology (2021)
4. Antioxidant Effects of Methanol Extract of Dracocephalum Kotschyi in Acetic Acid Induced Rat Colitis Model, Journal of Advances in Medical and Biomedical Research (2022)
5. Bioassay Standardization of Drug Dosage Form Prepared From Hydroalcoholic Extract of Dracocephalum Kotschyi, Journal of HerbMed Pharmacology (2022)
6. Antispasmodic Effects of Hydroalcoholic, Aqueous, Chloroform, and Ethyl Acetate Extracts of Zaringiah on Rabbit Ileum Smooth Muscle Contractions, Journal of HerbMed Pharmacology (2022)
7. Medicinal Properties and Active Constituents of Dracocephalum Kotschyi and Its Significance in Iran: A Systematic Review, Evidence-based Complementary and Alternative Medicine (2019)
8. Antispasmodic Effect of Hydroalcoholic and Flavonoids Extracts of Dracocephalum Kotschyi on Rabbit Bladder, Journal of HerbMed Pharmacology (2020)
Experts (# of related papers)
View all Related Experts
Hassan Sadraei (13)
Mohsen Minaiyan (11)
Other Related Docs
9. Effect of Vitamin D Supplement on Nonalcoholic Fatty Liver: A Systematic Review on Randomized Clinical Trials, Journal of Health System Research (2020)
10. Anti-Inflammatory and Analgesic Properties of Heracleum Persicum Essential Oil and Hydroalcoholic Extract in Animal Models, Journal of Ethnopharmacology (2009)
11. Effect of Tamarindus Indica L. Fruit Pulp and Seed Extracts on Experimental Ulcerative Colitis in Rats, Research in Pharmaceutical Sciences (2024)
12. The Effects of Sumac (Rhus Coriaria L.) Powder Supplementation in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial, Complementary Therapies in Clinical Practice (2020)
13. Hepatoprotective Effect of Silybum Marianum (L.) Gaertn. and Glycyrrhiza Glabra L. in the Rats, Journal of Medicinal Plants (2005)
14. In Vitro and in Vivo Anti-Toxoplasma Activities of Dracocephalum Kotschyi Extract in Experimental Models of Acute Toxoplasmosis, Acta Parasitologica (2022)
15. Anti-Inflammatory Effect of Apigenin and Hydroalcoholic Extract of Dracocephalum Kotschyi on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2017)
16. Antinociceptive and Anti-Inflammatory Activities of Satureja Hortensis Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models, Medical Principles and Practice (2012)
17. In Vitro and in Vivo Anti-Toxoplasma Activity of Dracocephalum Kotschyi Essential Oil, Food Science and Nutrition (2021)
18. Increasing the Effectiveness of Tyrosine Kinase Inhibitor (Tki) in Combination With a Statin in Reducing Liver Fibrosis, Clinical and Experimental Pharmacology and Physiology (2019)
19. Effects of the Mixture of Melissa Officinalis L., Cinnamomum Zeylanicutn and Urtica Dioica on Hepatic Enzymes Activity in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Pharmacology (2012)
20. The Effect of Dracocephalum Subcapitatum Hydroalcoholic Extract on Dexamethasone-Induced Hyperlipidemic Rats, Research in Pharmaceutical Sciences (2024)
21. Toxicity Effect of Holothuria Lessoni Sea Cucumber on Cancerous Mitochondria Obtained From Rat Model of Hepatocellular Carcinoma, Asian Pacific Journal of Cancer Prevention (2024)
22. Salvia Officinalis Leaf Extracts Protect Against Acute Colitis in Rats, Research in Pharmaceutical Sciences (2022)
23. Protective Effects of the Morus Alba L. Leaf Extracts on Cisplatininduced Nephrotoxicity in Rat, Research in Pharmaceutical Sciences (2013)
24. Antidiarrhoeal Assessment of Hydroalcoholic and Hexane Extracts of Dracocephalum Kotschyi Boiss. and Apigenin in Mice, Research in Pharmaceutical Sciences (2016)
25. Effect of Matricaria Aurea (Loefl.) Shultz-Bip. Hydroalcoholic Extract on Acetic Acid-Induced Acute Colitis in Rats, Iranian Journal of Basic Medical Sciences (2011)
26. Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum Pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats, Iranian Journal of Pharmaceutical Research (2009)
27. Solid Dispersion of Hesperetin Co-Crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats, Current Drug Delivery (2018)
28. Validation and Optimization of Experimental Colitis Induction in Rats Using 2, 4, 6-Trinitrobenzene Sulfonic Acid, Research in Pharmaceutical Sciences (2012)
29. The Effect of Essential Oil and Hydroalcoholic Extract of Dracocephalum Kotschyi on Isolated Heart and Blood Vessel Contractions, Journal of Isfahan Medical School (2024)
30. Protective Effects of Combined Losartan and Nilotinib on Carbon Tetrachloride (Ccl4)-Induced Liver Fibrosis in Rats, Drug and Chemical Toxicology (2020)
31. Antioxidant and Anti-Hyperlipidemic Effects of Bark Extract of Pinus Eldarica in Dexamethasone-Induced Dyslipidemic Rats, Journal of Advances in Medical and Biomedical Research (2019)
32. Evaluating Anti-Inflammatory Effect of Hydroalcoholic Extracts of Citrus Medica L. Pulp and Peel on Rat Model of Acute Colitis, Research Journal of Pharmacognosy (2023)
33. Evaluation of Anti-Ulcerative Effect of Eryngium Billardieri Extracts on Experimental Colitis in Rats, Physiology and Pharmacology (Iran) (2024)
34. Antihyperlipidemic Effect of Hydroalcoholic Extract, and Polyphenolic Fraction From Dracocephalum Kotschyi Boiss, Pharmaceutica Acta Helvetiae (1998)
35. Evaluation of the Flavonol-Rich Fraction of Rosa Damascena in an Animal Model of Liver Fibrosis by Targeting the Expression of Fibrotic Cytokines, Antioxidant/Oxidant Ratio and Collagen Cross-Linking, Life Sciences (2023)
36. Effects of Carum Carvi L. (Caraway) Extract and Essential Oil on Tnbs-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2013)
37. Hepatoprotective Effects of Iranian Hypericum Scabrum Essential Oils Against Oxidative Stress Induced by Acetaminophen in Rats, Brazilian Archives of Biology and Technology (2014)
38. Evaluation of Fibrinolytic and Antioxidant Effects of Allium Affine Hydroalcoholic Extract, Research in Pharmaceutical Sciences (2017)
39. The Effects of Hydroalcoholic Extract of Allium Elburzense Wendelbo Bulb on Dexamethasone-Induced Dyslipidemia, Hyperglycemia, and Oxidative Stress in Rats, Research in Pharmaceutical Sciences (2018)
40. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)
41. Protective Effect of Apium Graveolens L. (Celery) Seeds Extracts and Luteolin on Acetic Acid-Induced Colitis in Rats, International Journal of Preventive Medicine (2021)
42. Anti-Inflammatory Effect of Pycnocycla Spinosa Extract and Its Component Isoacetovanillone on Acetic Acid Induced Colitis in Rats, Research in Pharmaceutical Sciences (2015)
43. Antispasmodic Activity of Apigenin and Luteolin, Two Components of Dracocephalum Kotschyi Extract, on Rat Ileum Contractions, Journal of HerbMed Pharmacology (2018)
44. Antioxidant Activity and Preventive Effect of Aqueous Leaf Extract of Aloe Vera on Gentamicin-Induced Nephrotoxicity in Male Wistar Rats, Clinica Terapeutica (2014)
45. The Effects of Ethanol Extract of Berberis Vulgaris Fruit on Histopathological Changes and Biochemical Markers of the Liver Damage in Diabetic Rats, Iranian Journal of Basic Medical Sciences (2017)
46. Antispasmodic Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Rat Ileum Contraction, Research in Pharmaceutical Sciences (2015)
47. Effects of Lactulose and Silymarin on Liver Enzymes in Cirrhotic Rats, Canadian Journal of Physiology and Pharmacology (2017)
48. Allium Affine Extract Improves Dexamethasone-Induced Hyperlipidemia in Rats, Research Journal of Pharmacognosy (2023)
49. Anti-Inflammatory and Analgesic Properties of the Leaf Extracts and Essential Oil of Lavandula Angustifolia Mill., Journal of Ethnopharmacology (2003)
50. Effects of Olive Leaves Extract on Ldl Oxidation Induced-Cuso 4In Vitro, Pakistan Journal of Pharmaceutical Sciences (2012)