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Obesity and Angiogenesis



Tahergurabi Z1 ; Khazaei M2
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Student Research Committee, School of Medicine Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Nowadays, high prevalence of obesity and its consequences is considered as a major health complication worldwide. Overweight increases risk of diseases such as hypertension, cardiovascular diseases, type 2 diabetes, certain types of cancer, gallstone, and osteoarthritis. Obesity is defined as growth of visceral white adipose tissue. On the other hand, in order to supply for metabolic needs of adipose tissue, depends on appropriate growth of blood vessels, either in number and/or in size (angiogenesis/arteriogenesis). Moreover, the very close interconnection between adipogenesis and angiogenesis has been considered in recent years. Therapeutic interventions for treating obesity by targeting vessels of adipose tissue illustrate a promising future. In this review, we discussed adipose tissue, important roles and functions of vessels in adipose tissue, obesity, and angiogenesis. We finally presented suggestions on how to use anti-angiogenesis agents for treatment of obesity as a novel approach. © 2012, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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