Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Rosiglitazone Enhances Neovascularization in Diabetic Rat Ischemic Hindlimb Model Publisher Pubmed



Khazaei M1 ; Salehi E1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biomedical Papers Published:2012


Abstract

Background. There is increasing evidence that peroxisome proliferator-activated receptors (PPARs) may be involved in the regulation of angiogenesis. In this study, we examined whether rosiglitazone, a PPARγ agonist, can restore angiogenesis in a rat hindlimb ischemia model of diabetes. Methods. Male wistar rats were divided into four groups (n=6 each): control, diabetic and control and diabetic rats who received rosiglitazone (8 mg/kg/day). Diabetes was induced by streptozotocin (55 mg/kg; ip). After 21 days, serum concentrations of nitric oxide (NO), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-2 (VEGFR-2) were measured and neovascularization in ischemic legs was evaluated by immunohistochemistry. Results. Capillary density and capillary/fiber ratio in hindlimb ischemia of diabetic animals were significantly lower than the control group (P<0.05). Rosiglitazone significantly restored neovascularization in diabetic animals (P<0.05). Conclusions. rosiglitazone enhances neovascularization in diabetic ischemic skeletal muscle and could be considered for treatment of peripheral artery disease in diabetic subjects.
Related Docs
View other Related Docs
1. Role of Fenofibrate in Restoring Angiogenesis in Diabetic and Control Hind Limb Ischemic Rats, General Physiology and Biophysics (2012)
2. Effect of Rosiglitazone on Coronary Angiogenesis in Diabetic and Control Rats, Journal of Isfahan Medical School (2011)
3. Effects of Diabetes on Myocardial Capillary Density and Serum Angiogenesis Biomarkers in Male Rats, Clinics (2011)
4. Pan-Ppar Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats, International Journal of Peptides (2012)
5. Myocardial Capillary Density in Normal and Diabetic Male Rats: Effect of Bezafibrate, Research in Pharmaceutical Sciences (2013)
6. Limbs’ Postischemic Revascularization Is Not Improved by Losartan Treatment in Diabetic Rats, Endocrine Regulations (2014)
7. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
8. Angiogenesis in Health and Disease: Role of Vascular Endothelial Growth Factor (Vegf), Journal of Isfahan Medical School (2011)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (15)
Bahman Rashidi (10)
Other Related Docs
9. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
10. Role of Peroxisome Proliferator-Activated Receptor Β Agonist on Angiogenesis in Hindlimb Ischemic Diabetic Rats, Journal of Diabetes and its Complications (2012)
11. Role of Gw0742 a Pparβ/Δ Agonist on Coronary Angiogenesis in Control and Diabetic Rats, Journal of Isfahan Medical School (2011)
12. Effect of Resistance Training on Capillary Density Around Slow and Fast Twitch Muscle Fibers in Diabetic and Normal Rats, Asian Journal of Sports Medicine (2015)
13. Effect of L-Arginine and L-Name on Coronary Angiogenesis in Male Diabetic Rats, Journal of Research in Medical Sciences (2012)
14. Fenofibrate, a Peroxisome Proliferator-Activated Receptor Alpha, Improves Myocardial Capillary Density in Diabetic Rats., JPMA. The Journal of the Pakistan Medical Association (2012)
15. Imbalance of Angiogenesis in Diabetic Complications: The Mechanisms, International Journal of Preventive Medicine (2012)
16. Effect of Peroxisome Proliferator-Activated Receptors on Cardiac Remodeling in Normal and Diabetic Rats, Journal of Isfahan Medical School (2014)
17. Restoration of Angiogenesis by Enalapril in Diabetic Hindlimb Ischemc Rats, Biomedical Papers (2011)
18. Role of Peroxisome Proliferator-Activated Receptor Alpha and Gamma in Antiangiogenic Effect of Pomegranate Peel Extract, Iranian Journal of Basic Medical Sciences (2016)
19. The Sesame Lignan Sesamin Attenuates Vascular Permeability in Rats With Streptozotocin-Induced Diabetes: Involvement of Oxidative Stress, International Journal of Endocrinology and Metabolism (2011)
20. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
21. Inducible Nitric Oxide Synthase Modulates Angiogenesis in Ischemic Hindlimb of Rat, Biomedical Papers (2009)
22. The Effect of Pramlintide, an Antidiabetic Amylin Analogue, on Angiogenesis-Related Markers in Vitro, Research in Pharmaceutical Sciences (2020)
23. Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats, Journal of Isfahan Medical School (2014)
24. Hyperinsulinemia May Have a Protective Role in the Early Stages of Atherosclerosis in Rabbit Model of Hypercholesterolemia, Journal of Diabetes and Metabolic Disorders (2012)
25. Aqueous Concentrations of Vegf and Soluble Vegf Receptor-1 in Diabetic Retinopathy Patients, Journal of Research in Medical Sciences (2012)
26. Effect of Oral Magnesium Sulfate Administration on Blood Glucose Hemostasis Via Inhibition of Gluconeogenesis and Foxo1 Gene Expression in Liver and Muscle in Diabetic Rats, Biomedicine and Pharmacotherapy (2019)
27. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
28. Mas Receptor Antagonist (A799) Alters the Renal Hemodynamics Responses to Angiotensin Ii Administration After Renal Moderate Ischemia/Reperfusion in Rats: Gender Related Differences, Research in Pharmaceutical Sciences (2019)
29. Antioxidant and Cytoprotective Effects of L-Serine on Human Endothelial Cells, Research in Pharmaceutical Sciences (2012)
30. Obesity and Angiogenesis, Journal of Isfahan Medical School (2012)
31. The Effect of Maintenance and Reversal of Doca-Salt Hypertension on Extravasation of Macromolecules and Serum Nitric Oxide Concentration in Male Rats, Pathophysiology (2011)
32. The Effects of L-Arginine (The Precursor of Nitric Oxide) and L-Name (Nitric Oxide Synthase Inhibitor) on Coronary Angiogenesis in Normal Rats, Journal of Isfahan Medical School (2011)
33. Relationship Between Macular Thickness and the Ratio of Vascular Endothelial Growth Factor to Its Soluble Receptor 1 in Non-Proliferative Diabetic Retinopathy, Journal of Isfahan Medical School (2012)
34. Mechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes, International Journal of Endocrinology and Metabolism (2011)
35. Citral Protects Human Endothelial Cells Against Hydrogen Peroxide-Induced Oxidative Stress; [Sitral, Insan Endotel Hucrelerini Hidrojen Peroksitin Neden Oldugu Oksidatif Strese Karsi Korur], Turkish Journal of Pharmaceutical Sciences (2020)
36. Evaluation of Vascular Endothelial Growth Factor a and Leukemia Inhibitory Factor Expressions at the Time of Implantation in Diabetic Rats Following Treatment With Metformin and Pioglitazone, International Journal of Reproductive BioMedicine (2020)
37. Effects of Dapt on Serum Vascular Endothelial Growth Factor and Its Soluble Receptor in Obese Balb/C Mice, Journal of Isfahan Medical School (2013)
38. Evaluation of the Coronary Angiogenesis During Doca-Salt Induced Hypertension and Its Reversal to Normal in Rat, Pakistan Journal of Medical Sciences (2013)
39. Systemic Administration of Ghrelin Did Not Restore Angiogenesis in Hindlimb Ischemia in Control and Diet-Induced Obese Mice, Bratislava Medical Journal (2015)
40. The Vasorelaxant Effect of Simvastatin in Isolated Aorta From Diabetic Rats, ARYA Atherosclerosis (2016)
41. Oestrogen Promotes Coronary Angiogenesis Even Under Normoxic Conditions, Basic and Clinical Pharmacology and Toxicology (2008)
42. Effect of Oral Magnesium Sulfate Administration on Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Gene Expression to Prevent Atherosclerosis in Diabetic Rat Vessels, Journal of Diabetes Investigation (2019)
43. Long Term Administration of Thiamine Disulfide Improves Foxo1/Pepck Pathway in Liver to Reduce Insulin Resistance in Type 1 Diabetes Rat Model, Biomedicine and Pharmacotherapy (2024)
44. Interaction Between the Dietary Indices and Ppar-Γ Pro12ala Gene Variants on Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus, International Journal of Clinical Practice (2021)
45. The Role of Local Renin-Angiotensin System on High Glucose-Induced Cell Toxicity, Apoptosis and Reactive Oxygen Species Production in Pc12 Cells, Iranian Journal of Basic Medical Sciences (2014)
46. Impact of Metformin and Pioglitazone on Serum Level of Tumor Necrosis Factor-Alpha and Lipid Profiles During Implantation Window in Diabetic Rats, International Journal of Fertility and Sterility (2019)
47. Sulfaphenazole Treatment Restores Endothelium-Dependent Vasodilation in Diabetic Mice, Vascular Pharmacology (2008)
48. Enzymatic Antioxidant System and Endothelial Function in Patients With Metabolic Syndrome, ARYA Atherosclerosis (2020)
49. Nephrotoxicity Induced by Vascular Endothelial Growth Factor Inhibitors, Journal of Nephropharmacology (2022)
50. The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes, International Journal of Endocrinology (2012)