Isfahan University of Medical Sciences

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Extracellular Vesicles in Reproductive Medicines Publisher



K Mokhtari KHATERE ; M Sheykhhassan MOHSEN ; M Shahnazari MINA ; A Ahmadiehyazdi AMIRHOSSEIN ; N Shokrollah NILOOFAR ; P Samadi PARISA ; P Yang PIAO
Authors

Source: Published:2025


Abstract

Extracellular vesicles (EVs) are small particles released by cells. They play crucial roles in intercellular communication and have significant implications in reproductive medicine—a field encompassing the study and treatment of reproductive health and diseases. EVs contribute to the development and function of reproductive organs by transferring molecular signals and impacting gene expression. They originate from diverse sources within the reproductive system, such as testicular and ovarian fluids, and their properties are influenced by factors like hormonal levels and tissue health. Importantly, EVs hold potential as biomarkers and therapeutic agents for reproductive disorders, including infertility and endometriosis. They offer novel insights for diagnosis and treatment by reflecting the physiological state of reproductive tissues and delivering targeted treatments. Current research is focused on understanding their mechanisms and ensuring their safety and effectiveness in clinical applications. Collaboration across various scientific disciplines is essential for advancing the use of EVs in reproductive medicine. © 2025 Elsevier B.V., All rights reserved.