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The Impact of Exosomes on Bone Health: A Focus on Osteoporosis Publisher Pubmed



Mehrvar A1 ; Akbari M2 ; Khosroshahi EM3, 5, 17 ; Nekavand M3, 5, 17 ; Mokhtari K7 ; Baniasadi M8 ; Aghababaian M10 ; Karimi M11 ; Amiri S12 ; Moazen A13 ; Maghsoudloo M14 ; Alimohammadi M15 ; Rahimzadeh P16 ; Farahani N2 Show All Authors
Authors
  1. Mehrvar A1
  2. Akbari M2
  3. Khosroshahi EM3, 5, 17
  4. Nekavand M3, 5, 17
  5. Mokhtari K7
  6. Baniasadi M8
  7. Aghababaian M10
  8. Karimi M11
  9. Amiri S12
  10. Moazen A13
  11. Maghsoudloo M14
  12. Alimohammadi M15
  13. Rahimzadeh P16
  14. Farahani N2
  15. Vaghar ME3, 5, 17
  16. Entezari M3, 5, 17
  17. Hashemi M3, 5, 17
Show Affiliations
Authors Affiliations
  1. 1. Department of Orthopedics, Taleghani Hospital Research Development Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Iran
  3. 3. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Department of Midwifery, Faculty of nursing and midwifery, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  7. 7. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Iran
  8. 8. Department of Orthopedic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. MD, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Orthopedic Surgery, Isfahan University of Medical Sciences, Iran
  11. 11. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, MD, Liberia
  12. 12. MD, Assistant Professor of Orthopaedic Surgery, Shohadaye Haftom-e-Tir Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Iran
  14. 14. Key Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, PR China, 646000, Sichuan, China
  15. 15. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  16. 16. Surgical Research Society (SRS), Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  17. 17. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  18. 18. Department of gynecology, Faculty of Medicine, Tehran Medical sciences, Islamic Azad University, Tehran, Iran

Source: Pathology, research and practice Published:2024


Abstract

Osteoporosis is a widespread chronic condition. Although standard treatments are generally effective, they are frequently constrained by side effects and the risk of developing drug resistance. A promising area of research is the investigation of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, which play a crucial role in bone metabolism. Exosomes, in particular, have shown significant potential in both the diagnosis and treatment of osteoporosis. EVs derived from osteoclasts, osteoblasts, mesenchymal stem cells, and other sources can influence bone metabolism, while exosomes from inflammatory and tumor cells may exacerbate bone loss, highlighting their dual role in osteoporosis pathology. This review offers a comprehensive overview of EV biogenesis, composition, and function in osteoporosis, focusing on their diagnostic and therapeutic potential. We examine the roles of various types of EVs and their cargo-proteins, RNAs, and lipids-in bone metabolism. Additionally, we explore the emerging applications of EVs as biomarkers and therapeutic agents, emphasizing the need for further research to address current challenges and enhance EV-based strategies for managing osteoporosis. Copyright © 2024 Elsevier GmbH. All rights reserved.
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