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The Role of Mirnas From Mesenchymal Stem/Stromal Cells-Derived Extracellular Vesicles in Neurological Disorders Publisher Pubmed



Jafarinia M1 ; Farrokhi MR1, 2 ; Ganjalikhani Hakemi M3, 4 ; Cho WC5
Authors
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Authors Affiliations
  1. 1. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Neurosurgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong

Source: Human Cell Published:2023


Abstract

Mesenchymal stem/stromal cells (MSCs) are multipotent cells with immunomodulatory effects that have been attempted as a possible treatment for neurologic disorders. Since currently available drugs for neurologic disorders are limited, special attention has been paid to MSCs. With the ability to differentiate into neural cells, it has been shown that MSCs exert their effects in a paracrine manner by producing extracellular vesicles (EVs). Extracellular vesicles are small vesicles with a size of 30–1000 nm that are released by cells, such as MSCs, T cells, B cells, etc. EVs contain various molecules, including proteins, lipids, mRNAs, and microRNAs (miRNAs). In recent years, the administration of EVs in models of neurological disorders has been shown to improve neurological dysfunctions. miRNAs from MSC-EVs as one of the important mediators which regulate various genes and reduce neuropathological change have been identified in different neurological disorders. Here, we review the effects of EVs miRNAs from MSCs on different neurological disorders and their potential applications. © 2022, The Author(s) under exclusive licence to Japan Human Cell Society.
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