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A High-Efficient Antibacterial and Biocompatible Polyurethane Film With Ag@Rgo Nanostructures Prepared by Microwave-Assisted Method: Physicochemical and Dermal Wound Healing Evaluation Publisher



Mohammadi A1 ; Kerdabadi ZG2 ; Ayati Najafabadi SA3 ; Pourali A2 ; Nejaddehbashi F4 ; Azarbarz N4 ; Kahkesh KH5 ; Ebrahimibagha M6
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran
  2. 2. School of Chemistry, Damghan University, Damghan, 36716-41167, Iran
  3. 3. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Cellular and Molecular Research Center, Medical Basic Sciences Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Basic Medical Science, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  6. 6. Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Source: Heliyon Published:2023


Abstract

Wound infections are a significant issue that can hinder the wound healing process. One way to address this problem is by enhancing the antibacterial activity of wound dressings. Accordingly, this work focuses on developing a castor-oil-based antibacterial polyurethane nanocomposite film impregnated with silver nanoparticles (AgNPs) decorated on the surface of reduced graphene oxide (rGO) nanostructures (Ag@rGO). To this aim, rGOs act as a platform to stabilize AgNPs and improve their bioavailability and dispersion quality within the PU film. The microwave-assisted synthesis of Ag@rGO nanohybrids was proved by FTIR, XRD, TGA, FE-SEM, EDS, and TEM analyses. Compared to PU/GO, the effect of Ag@rGO nanohybrids on thermo-mechanical features, morphology, antibacterial activity, cytocompatibility, and in vivo wound healing was assessed. SEM photomicrographs revealed the enhanced dispersion of Ag@rGO nanohybrids compared to GO nanosheets. Besides, according to XRD results, PU/Ag@rGO nanocomposite film demonstrated higher microphase mixing, which could be due to the finely dispersed Ag@rGO nanostructures interrupting the hydrogen bonding interactions in the hard segments. Moreover, PU/Ag@rGO nanocomposite showed excellent antibacterial behavior with completely killing E. coli and S. aureus bacteria. In vitro and in vivo wound healing studies displayed PU/Ag@rGO film effectively stimulated fibroblast cells proliferation, migration and re-epithelialization. However, the prepared antibacterial PU/Ag@rGO nanocomposite film has the potential to be used as a biomaterial for dermal wound healing applications. © 2023 The Authors
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