Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Antibacterial Host-Guest Intercalated Ldh-Adorned Polyurethane for Accelerated Dermal Wound Healing Publisher Pubmed



Mohammadi A1 ; Abdolvand H1 ; Ayati Najafabadi SA2 ; Nejaddehbashi F3 ; Beigiboroujeni S4 ; Makvandi P5 ; Daemi H6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran
  2. 2. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran
  3. 3. Cellular and Molecular Research Center, Medical Basic Sciences Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran
  4. 4. School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada Sur, Monterrey, 2501, Mexico
  5. 5. Centre for Materials Interface, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy
  6. 6. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, 16656-66311, Iran

Source: ACS Applied Bio Materials Published:2022


Abstract

Curcumin has a limited clinical application because of its extremely poor accessibility. In the present study, improved curcumin bioavailability within a castor oil polyurethane/layered double hydroxide (LDH) wound cover was achieved by preparing a curcumin p-sulfonic acid calix[4]arene (SC4A) inclusion complex. Then, it was utilized to intercalate MgAl-layered double hydroxide (MgAl-LDH) nanosheets. The incorporation of the nanostructure into a PU/Cur-SC4A-LDH film provided bacteria-killing performance against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. This finding is due to an increase in curcumin bioavailability in the PU matrix. Furthermore, all PU nanocomposites exhibited appropriate cytocompatibility based on an MTT assay. Mainly, the proliferation of L929 fibroblast cells in contact with the PU/Cur-SC4A-LDH sample was significantly further enhanced than that for other nanocomposites within 7 days. This observation can be related to the better availability of curcumin on the film's surface, which causes an improvement in the proliferation rate of cells. Regarding the histological results, the hematoxylin and eosin (H&E) images showed faster epidermal layer formation and a larger quantity of matured hair follicles for PU/Cur-SC4A-LDH-healed wounds in comparison with those for the negative control over a period of 28 days. Thus, this practical healing ability of the PU/Cur-SC4A-LDH nanocomposite makes it a promising candidate as a wound dressing film. copy; 2022 American Chemical Society. © 2022 American Chemical Society. All rights reserved.
Related Docs
View other Related Docs
1. Improvement in Bioavailability of Curcumin Within the Castor-Oil Based Polyurethane Nanocomposite Through Its Conjugation on the Surface of Graphene Oxide Nanosheets, Polymers for Advanced Technologies (2022)
2. A High-Efficient Antibacterial and Biocompatible Polyurethane Film With Ag@Rgo Nanostructures Prepared by Microwave-Assisted Method: Physicochemical and Dermal Wound Healing Evaluation, Heliyon (2023)
3. Preparation and Characterization of Carboxymethyl Cellulose/Polyethylene Glycol Films Containing Bromelain/Curcumin: In Vitro Evaluation of Wound Healing Activity, Polymer Engineering and Science (2024)
4. Silver(I) Complex With a Schiff Base Ligand Extended Waterborne Polyurethane: A Developed Strategy to Obtain a Highly Stable Antibacterial Dispersion Impregnated With in Situ Formed Silver Nanoparticles, Chemical Engineering Journal (2020)
5. Evaluation of Wound Healing and Antimicrobial Properties of Hydrogel Dressings of Starch Containing Ethanolic Extract of Propolis in the Rat, Journal of Isfahan Medical School (2018)
6. Preparation and Characterization of an Antibacterial Cmc/Pcl Hydrogel Films Containing Cip/Cur: In Vitro and in Vivo Evaluation of Wound Healing Activity, International Journal of Biological Macromolecules (2024)
7. Local Delivery of Usnic Acid Loaded Rhamnolipid Vesicles by Gelatin / Tragacanth Gum / Montmorillonite/ Vanillin Cryogel Scaffold for Expression of Osteogenic Biomarkers and Antimicrobial Activity, Journal of Drug Delivery Science and Technology (2022)
8. Physical and Biological Properties of Blend-Electrospun Polycaprolactone/Chitosan-Based Wound Dressings Loaded With N-Decyl-N, N-Dimethyl-1-Decanaminium Chloride: An in Vitro and in Vivo Study, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Rafienia (7)
Jaleh Varshosaz (3)
Other Related Docs
9. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
10. Antisolvent Precipitation Technique: A Very Promising Approach to Crystallize Curcumin in Presence of Polyvinyl Pyrrolidon for Solubility and Dissolution Enhancement, Colloids and Surfaces B: Biointerfaces (2016)
11. Phytosomal Curcumin: A Review of Pharmacokinetic, Experimental and Clinical Studies, Biomedicine and Pharmacotherapy (2017)
12. An in Vitro and in Vivo Study of Pcl/Chitosan Electrospun Mat on Polyurethane/Propolis Foam As a Bilayer Wound Dressing, Biomaterials Advances (2022)
13. Comparing the Wound Healing Effect of a Controlled Release Wound Dressing Containing Curcumin/Ciprofloxacin and Simvastatin/Ciprofloxacin in a Rat Model: A Preclinical Study, Journal of Biomedical Materials Research - Part A (2022)
14. Cerium Oxide Nanoparticles: Synthesis Methods and Applications in Wound Healing, Materials Today Bio (2023)
15. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
16. Curcumin Nanoparticles Containing Poloxamer or Soluplus Tailored by High Pressure Homogenization Using Antisolvent Crystallization, International Journal of Pharmaceutics (2019)
17. Clinical Trials, Patents, and Marketed Products of Nanocurcumin-Based Anticancer Drug Delivery Systems, Curcumin-Based Nanomedicines as Cancer Therapeutics (2024)
18. Electrospun Core-Shell Polycaprolactone/ Chitosan Nanofibrous Composite With Enhanced Curcumin Loading Capacity for Wound Healing Applications, Materials Today Chemistry (2024)
19. In-Vitro Effects of Copper Nanoparticles on Common Bacterial Strains Implicated in Nosocomial Infections, Journal of Isfahan Medical School (2013)
20. Alginate Hydrogel Enriched With Ambystoma Mexicanum Epidermal Lipoxygenase-Loaded Pectin Nanoparticles for Enhanced Wound Healing, Journal of Biomaterials Applications (2020)
21. Cornstarch-Based Wound Dressing Incorporated With Hyaluronic Acid and Propolis: In Vitro and in Vivo Studies, Carbohydrate Polymers (2019)
22. A Propolis Enriched Polyurethane-Hyaluronic Acid Nanofibrous Wound Dressing With Remarkable Antibacterial and Wound Healing Activities, International Journal of Biological Macromolecules (2020)
23. Electrophoretic-Deposited Hydroxyapatite-Copper Nanocomposite As an Antibacterial Coating for Biomedical Applications, Surface and Coatings Technology (2017)
24. Antimicrobial Effect of Curcumin Nanoparticles and Ferulago Angulate Boiss Extract Against Methicillin-Resistant Staphylococcus Aureus (Mrsa) Isolated From Wound Infections, BioNanoScience (2024)
25. A Multifunctional Nanocomposite Spray Dressing of Kappa-Carrageenan-Polydopamine Modified Zno/L-Glutamic Acid for Diabetic Wounds, Materials Science and Engineering C (2020)
26. Wound Dressing Application of Castor Oil- and Capa-Based Polyurethane Membranes, Polymer Bulletin (2020)
27. Polyurethane-Nanolignin Composite Foam Coated With Propolis As a Platform for Wound Dressing: Synthesis and Characterization, Polymers (2021)
28. Delivery of Antibacterial Agents for Wound Healing Applications Using Polysaccharide-Based Scaffolds, Journal of Drug Delivery Science and Technology (2023)
29. Peptide-Functionalized Polymeric Nanoparticles for Delivery of Curcumin to Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
30. Efficient Biocompatible Drug Carrier: Lignin-Based Nanogel Amplifies Curcumin's Cytotoxic Effects and Induces Apoptosis in Brain and Lung Cancer Cell Lines, Biocatalysis and Agricultural Biotechnology (2024)
31. Sustained Release Investigation of Curcumin and Ciprofloxacin on Coaxial Electrospun Nanocomposite Scaffold of Poly (3-Hydroxybutyrate)-Poly Glycerol Sebacate: An Approach for Skin Regeneration, Emergent Materials (2024)
32. Effect of Nano-Curcumin on Various Diseases: A Comprehensive Review of Clinical Trials, BioFactors (2023)
33. Preparation and Characterization of Cuo, Ag2o and Zno Nanoparticles and Investigation of Their Antibacterial and Anticancer Properties on Hct-116 and C26 Cells, Inorganic Chemistry Communications (2023)
34. Lipid-Based Nanodelivery Systems of Curcumin: Recent Advances, Approaches, and Applications, Food Chemistry (2025)