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Mitochondrial Dna and Y-Chromosome Variation in the Caucasus Publisher Pubmed



Nasidze I1 ; Ling EYS1, 2, 10 ; Quinque D1 ; Dupanloup I3 ; Cordaux R1 ; Rychkov S4 ; Naumova O4 ; Zhukova O4 ; Sarrafzadegan N5 ; Naderi GA5 ; Asgary S5 ; Sardas S6 ; Farhud DD7 ; Sarkisian T8 Show All Authors
Authors
  1. Nasidze I1
  2. Ling EYS1, 2, 10
  3. Quinque D1
  4. Dupanloup I3
  5. Cordaux R1
  6. Rychkov S4
  7. Naumova O4
  8. Zhukova O4
  9. Sarrafzadegan N5
  10. Naderi GA5
  11. Asgary S5
  12. Sardas S6
  13. Farhud DD7
  14. Sarkisian T8
  15. Asadov C9
  16. Kerimov A9
  17. Stoneking M1
Show Affiliations
Authors Affiliations
  1. 1. Max Planck Inst. Evol. Anthropology, Leipzig D-04103, Deutscher Platz 6, Germany
  2. 2. Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
  3. 3. Ferrara University, Department of Biology, 44100 Ferrara, Via L. Borsari 46, Italy
  4. 4. Vavilov Inst. of General Genetics, 119991 Moscow, Gubkin str. 3, Russian Federation
  5. 5. Isfahan Cardiovasc. Research Center, Isfahan, Iran
  6. 6. Gazi University, Toxicology Department, 06330 Ankara, Turkey
  7. 7. Tehran Univ. of Medical Sciences, Department of Human Genetics, Tehran, P.O. Box 14155-6446, Iran
  8. 8. Center of Medical Genetics, Natl. Acad. Sci. of Republic Armenia, 375010 Yerevan, 5/1 Zakyan Str., Armenia
  9. 9. Sci.-Res. Inst. Hematol./Transfusiol, Azerbaijan Rep. Ministry of Health, Baku, Gashgay Str. 87, Azerbaijan
  10. 10. Wellcome Trust Ctr. for Human Genet., University of Oxford, Oxford OX3 7BN, Roosevelt Drive, United Kingdom

Source: Annals of Human Genetics Published:2004


Abstract

We have analyzed mtDNA HVI sequences and Y chromosome haplogroups based on 11 binary markers in 371 individuals, from 11 populations in the Caucasus and the neighbouring countries of Turkey and Iran. Y chromosome haplogroup diversity in the Caucasus was almost as high as in Central Asia and the Near East, and significantly higher than in Europe. More than 27% of the variance in Y-haplogroups can be attributed to differences between populations, whereas mtDNA showed much lower heterogeneity between populations (less then 5%), suggesting a strong influence of patrilocal social structure. Several groups from the highland region of the Caucasus exhibited low diversity and high differentiation for either or both genetic systems, reflecting enhanced genetic drift in these small, isolated populations. Overall, the Caucasus groups showed greater similarity with West Asian than with European groups for both genetic systems, although this similarity was much more pronounced for the Y chromosome than for mtDNA, suggesting that male-mediated migrations from West Asia have influenced the genetic structure of Caucasus populations. © University College London 2004.
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